Probiotics reduce psychological stress in patients before laryngeal cancer surgery
Abstract
AIM: Laryngeal cancer is a common malignancy; surgery is the preferred treatment. Psychosocial stress is one of the negative impacts on patient recovery. This study aimed to elucidate the effect of probiotics on ameliorating anxiety, and on serum corticotropin-releasing factor (CRF) in laryngeal cancer patients before surgery. METHODS: A total 30 patients with laryngeal cancer and 20 healthy volunteers were recruited. During the 2 weeks before surgery, 20 patients were randomly allocated to receive probiotics or placebo twice a day. Heart rate was recorded daily. The degree of anxiety was assessed by the Hamilton Anxiety Scale (HAMA). RESULTS: Serum CRF levels in laryngeal cancer patients increased significantly in approaching surgery. After ingestion of probiotics, serum levels of CRF and heart rate did not increase before surgery. In addition, taking probiotics relieved the degree of anxiety of the patients from HAMA 19.8 to 10.2. CONCLUSION: Probiotics can ameliorate the clinical anxiety and biochemical features of stress in patients scheduled for laryngectomy.
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Administration of Clostridium butyricum from phylum Firmicutes can block increased CRF levels in patients before surgical procedures.
“Interestingly, administration of Clostridium butyricum from the phylum Firmicutes can block increased CRF levels in patients before surgical procedures [361].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [361]
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- Authors
- Yang, H., Zhao, X., Tang, S., Huang, H., Zhao, X., Ning, Z., Fu, X., & Zhang, C.
- Affiliations
- Shanxi Medical University (CN)
- Department of Nursing The First Hospital Shanxi Medical University Taiyuan China
- Corresponding author
- Yang, Hui
- Venue
- Asia-Pacific Journal of Clinical Oncology
- Publisher
- Wiley
- Published
- 2014-02-20
- Volume
- 12
- Issue
- 1
- Pages
- e92-6
- ISSN
- 1743-7555 (ISSN-L)
- 1743-7563
- OpenAlex
- W1898466328
- Cited by
- 66
- References
- 15
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 7
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asia-Pacific Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanxi Provincial Scientific Research (#021066)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- probiotics, laryngeal cancer, preoperative anxiety, psychological stress, corticotropin-releasing factor, laryngectomy, heart rate, Hamilton Anxiety Rating Scale, preoperative stress
- MeSH terms
- Aged, Anxiety, Corticotropin-Releasing Hormone, Female, Humans, Laryngeal Neoplasms, Male, Middle Aged, Stress, Psychological, Otorhinolaryngologic Surgical Procedures, Probiotics
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