The DOI matches its Crossref record; 25 of the 27 references it cites were found in a registry or an index.
Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
Open accessAbstract
Macroencapsulation devices provide the dual possibility of immunoprotecting transplanted cells while also being retrievable, the latter bearing importance for safety in future trials with stem cell-derived cells. However, macroencapsulation entails a problem with oxygen supply to the encapsulated cells. The βAir device solves this with an incorporated refillable oxygen tank. This phase 1 study evaluated the safety and efficacy of implanting the βAir device containing allogeneic human pancreatic islets into patients with type 1 diabetes. Four patients were transplanted with 1-2 βAir devices, each containing 155 000-180 000 islet equivalents (ie, 1800-4600 islet equivalents per kg body weight), and monitored for 3-6 months, followed by the recovery of devices. Implantation of the βAir device was safe and successfully prevented immunization and rejection of the transplanted tissue. However, although beta cells survived in the device, only minute levels of circulating C-peptide were observed with no impact on metabolic control. Fibrotic tissue with immune cells was formed in capsule surroundings. Recovered devices displayed a blunted glucose-stimulated insulin response, and amyloid formation in the endocrine tissue. We conclude that the βAir device is safe and can support survival of allogeneic islets for several months, although the function of the transplanted cells was limited (Clinicaltrials.gov: NCT02064309).
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“these macroencapsulation devices can also promote fibrosis around the implant, further preventing nutrient diffusion.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [92]
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Cites
The rand 36‐item health survey 1.0
Hays, R. D., Sherbourne, C. D., & Mazel, R. M. (1993) · Health Economics · doi:10.1002/hec.4730020305 · Cited by 2,971
Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645 · cited 1×
“22-24 The problems encountered could be attributed to (1) the significant contribution of glucose effectiveness for glucose metabolism in small animals,25 (2) limited islet survival due to diffusion problems of oxygen and nutrients occurring when the device has been upscaled from harboring a few hundred islets to enco…”
Self-citationLive encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation
Elliott, R. B., Escobar, L., Tan, P., Muzina, M., Zwain, S., & Buchanan, C. M. (2007) · Xenotransplantation · doi:10.1111/j.1399-3089.2007.00384.x · Cited by 409
Bradley, C., & Lewis, K. S. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01421.x · Cited by 380
Microencapsulated Pancreatic Islet Allografts Into Nonimmunosuppressed Patients With Type 1 Diabetes
Calafiore, R., Basta, G., Luca, G., Lemmi, A., Montanucci, M. P., Calabrese, G., Racanicchi, L., Mancuso, F., & Brunetti, P. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-1270 · Cited by 342
Safety and Viability of Microencapsulated Human Islets Transplanted Into Diabetic Humans
Tuch, B., Keogh, G., Williams, L., Wu, W., Foster, J., Vaithilingam, V., & Philips, R. (2009) · Diabetes Care · doi:10.2337/dc09-0744 · Cited by 329
Transplantation of human islets without immunosuppression
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A. V., Block, N. L., Colton, C. K., Ludwig, S., Kersting, S., Bonifacio, E. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317561110 · Cited by 286 · cited 3×
“Even so, the kinetics of glucosestimulated insulin release during an intravenous glucose tolerance test showed a significant delay in secreted Cpeptide over a 4- hour period also at the preperitoneal space.(7) Given the physiological differences between different tissue compartments, especially regarding vascularity,…”
InfluentialSelf-citationStaining methods for identification of amyloid in tissue.
Westermark, G., Johnson, K., & Westermark, P. (1999) · Methods in Enzymology · doi:10.1016/s0076-6879(99)09003-5 · Cited by 266 · cited 1×
“Alginateembedded formalinfixed slabs and islets from the pancreas donors were stained with Congo red according to Puchtler and Sweat,(12) and the presence of amyloid was determined in polarized light.(13) Biopsies from the tissue surrounding the device were obtained at explantation and fixed in formalin.”
Self-citationGoto, M., Eich, T., Felldin, M., Foss, A., Källén, R., Salmela, K., Tibell, A., Tufveson, G., Fujimori, K., Engkvist, M., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000140882.53773.dc · Cited by 235 · cited 1×
“Human pancreatic islets were isolated from pancreases procured donation after brain death (DBD) donors in GMP facilities according to clinical routine.(8) Descriptive data for each islet donor are provided in Table S1.”
Self-citationWhy do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?
de Vos, P., van Straaten, J. F. M., Nieuwenhuizen, A., de Groot, M., Ploeg, R., de Haan, B. D., & van Schilfgaarde, R. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1381 · Cited by 206
Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas
Barkai, U., Weir, G. C., Colton, C. K., Ludwig, B., Bornstein, S. R., Brendel, M. D., Neufeld, T., Bremer, C., Leon, A., Evron, Y., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657341 · Cited by 202
Self-citationWidespread Amyloid Deposition in Transplanted Human Pancreatic Islets
Westermark, G. T., Westermark, P., Berne, C., & Korsgren, O. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0802893 · Cited by 187
Self-citationCONGO RED AS A STAIN FOR FLUORESCENCE MICROSCOPY OF AMYLOID
Puchtler, H., & Sweat, F. (1965) · Journal of Histochemistry and Cytochemistry · doi:10.1177/13.8.693 · Cited by 186
Ludwig, B., Rotem, A., Schmid, J., Weir, G. C., Colton, C. K., Brendel, M. D., Neufeld, T., Block, N. L., Yavriyants, K., Steffen, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201868109 · Cited by 182
Self-citationOxygen supply to encapsulated therapeutic cells.
Colton, C. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.007 · Cited by 153 · cited 1×
“22-24 The problems encountered could be attributed to (1) the significant contribution of glucose effectiveness for glucose metabolism in small animals,25 (2) limited islet survival due to diffusion problems of oxygen and nutrients occurring when the device has been upscaled from harboring a few hundred islets to enco…”
The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs
Neufeld, T., Ludwig, B., Barkai, U., Weir, G. C., Colton, C. K., Evron, Y., Balyura, M., Yavriyants, K., Zimerman, B., Azarov, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070150 · Cited by 124
Self-citationChicheportiche, D., & Reach, G. (1988) · Diabetologia · doi:10.1007/bf00279134 · Cited by 115 · cited 1×
“Islets even in small alginate capsules (≈ 350 μm in diameter) demonstrated a severely blunted response to high glucose and theophylline, whereas islets encapsulated in larger capsules (≈650 μm in diameter) failed to respond.(21) Notably, using the same in vitro conditions, the authors showed that the response to gluco…”
Brauker, J., Martinson, L., Young, S., & Johnson, R. C. (1996) · Transplantation · doi:10.1097/00007890-199606270-00002 · Cited by 98
Oxygenation of islets and its role in transplantation
Lau, J., Henriksnäs, J., Svensson, J., & Carlsson, P. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32833239ff · Cited by 82 · cited 1×
“22-24 The problems encountered could be attributed to (1) the significant contribution of glucose effectiveness for glucose metabolism in small animals,25 (2) limited islet survival due to diffusion problems of oxygen and nutrients occurring when the device has been upscaled from harboring a few hundred islets to enco…”
Self-citationEriksson, O., Espes, D., Selvaraju, R. K., Jansson, E. T., Antoni, G., Sørensen, J. C. H., Lubberink, M., Biglarnia, A., Eriksson, J. W., Sundin, A., et al. (2014) · Diabetes · doi:10.2337/db13-1877 · Cited by 67
Self-citationTibell, A., Rafael, E., Wennberg, L., Nordenström, J., Bergström, M., Geller, R., Loudovaris, T., Johnson, R. C., Brauker, J., Neuenfeldt, S. K., et al. (2001) · Cell Transplantation · doi:10.3727/000000001783986404 · Cited by 62
Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts
Westermark, G. T., Davalli, A. M., Secchi, A., Folli, F. B., Kin, T., Toso, C., Shapiro, A. M. J., Korsgren, O., Tufveson, G., Andersson, A., et al. (2011) · Transplantation · doi:10.1097/tp.0b013e31823e46ef · Cited by 48
Self-citationExtensive amyloid formation in transplanted microencapsulated mouse and human islets
Bohman, S., & Westermark, G. T. (2012) · Amyloid · doi:10.3109/13506129.2012.679988 · Cited by 20 · cited 1×
“14,16 Impaired diffusion kinetics of IAPP over the immune barrier might have aggravated amyloid formation when compared to that observed after transplantation of nonencapsulated islets.(15)”
Self-citationGlucose Effectiveness: The Mouse Trap in the Development of Novel ß-Cell Replacement Therapies
Korsgren, E., & Korsgren, O. (2016) · Transplantation · doi:10.1097/tp.0000000000000900 · Cited by 17
Self-citationMacroencapsulation Protects Against Sensitization after Allogeneic Islet Transplantation in Rats
Sörenby, A., Wu, G.-S. S., Zhu, S., Wernerson, A., Sumitran-Holgersson, S., & Tibell, A. (2006) · Transplantation · doi:10.1097/01.tp.0000228912.62374.44 · Cited by 16
Flagged first, then by citations
2 of the 27 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Ekberg, 2007, C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy, Diabetes Care., 30, 71, 10.2337/dc06-1274 · DOI
- Leu, 1992, Microencapsulated pancreatic islets: a pathologic study, J Formos Med Assoc., 91, 849
Cited by
Sorted by citations
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
Rickels, M. R., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00154 · Cited by 329
Biotechnology and Bioengineering: Volume 117, Number 1, January 2020
Anane, E., García, Á. C., Haby, B., Hans, S., Krausch, N., Krewinkel, M., Hauptmann, P., Neubauer, P., & Bournazou, M. N. C. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26757 · Cited by 246
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210
Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond
Farina, M., Alexander, J. F., Thekkedath, U. R., Mauro Ferrari, B., & Grattoni, A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.018 · Cited by 194
Engineering islets from stem cells for advanced therapies of diabetes
Siehler, J., Blöchinger, A. K., Meier, M., & Lickert, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00262-w · Cited by 125
Metadata
- Authors
- Carlsson, P.-O., Espes, D., Sedigh, A., Rotem, A., Zimerman, B., Grinberg, H., Goldman, T., Barkai, U., Avni, Y., Westermark, G. T., Carlbom, L., Ahlström, H., Eriksson, O., Olerud, J., & Korsgren, O.
- Affiliations
- Uppsala University (SE)
- Beta-O2 Technologies (Israel) (IL)
- Corresponding author
- Carlsson, Per-Ola
- ORCID
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 18
- Issue
- 7
- Pages
- 1735-1744
- ISSN
- 1600-6135 (ISSN-L)
- PMC
- PMC6055594
- OpenAlex
- W2777721344
- Cited by
- 205
- References
- 27
- Citations by year
- 2026: 22 · 2025: 15 · 2024: 21 · 2023: 22 · 2022: 23 · 2021: 31 · 2020: 32 · 2019: 26 · 2018: 12
- FWCI
- 19.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Transplantation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Funders
- Juvenile Diabetes Research Foundation International
- Diabetes Research & Wellness Foundation
- Stiftelsen Familjen Ernfors Fond
- Diabetesfonden
- Vetenskapsrådet (921-2014-7054, K2013-55X-15043, K2015-54X-12219-19-4, K2016-01040, K2016-GTW)
- Novo Nordisk
- European Research Council (F4-2013-602889, 646075-ELASTISLET)
- Leona M. and Harry B. Helmsley Charitable Trust
- Barndiabetesfonden
- EXODIAB
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- macroencapsulation, bioartificial pancreas, type 1 diabetes, islet transplantation, oxygen supply, immunoprotection, islet survival, C-peptide, amyloid fibril formation, capsule fibrosis, device retrieval, treatment efficacy and safety
- MeSH terms
- Adolescent, Blood Glucose, Capsules, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Humans, Islets of Langerhans, Male, Monitoring, Physiologic, Prognosis, Islets of Langerhans Transplantation, Pancreas, Artificial, Bioartificial Organs
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