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Cited by 417

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

First clinical-grade porcine kidney xenotransplant using a human decedent model

Porrett, Paige M., Orandi, Babak J., Kumar, Vineeta, Houp, Julie, Anderson, Douglas, Cozette Killian, A., Hauptfeld-Dolejsek, Vera, Martin, Dominique E., Macedon, Sara, Budd, Natalie, Stegner, Katherine L., Dandro, Amy, Kokkinaki, Maria, Kuravi, Kasinath V., Reed, Rhiannon D., Fatima, Huma, Killian, John T., Baker, Gavin, Perry, Jackson, Wright, Emma D., Cheung, Matthew D., Erman, Elise N., Kraebber, Karl, Gamblin, Tracy, Guy, Linda, George, James F., Ayares, David, Locke, Jayme E.·2022·American Journal of Transplantation
DOI 10.1111/ajt.16930
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  • Elimination of growth hormone receptor gene expression could reduce organ sizes but comes with other undesired biological consequences.

    “Although elimination of growth hormone receptor gene expression could reduce organ sizes2,3, it comes with other undesired biological consequences7.”

    From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [2]

    Section 2.3.1 reports that growth hormone receptor knockout was accompanied by reduced serum IGF-1 levels and body weight, establishing a biological effect beyond organ size. It does not characterize the lower IGF-1 level as undesired. The Discussion attributes altered renal structural integrity to the pigs’ genetic modifications collectively, not specifically to growth hormone receptor knockout. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

  • Xenotransplantation may offer a transformative solution to the worldwide organ shortage crisis.

    “Xenotransplantation may offer a transformative solution to the worldwide organ shortage crisis1–3.”

    From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [2]

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Citations

Cites

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Research works printed but not linked: 31

  1. Wolfe, 1999, Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant, N Engl J Med., 341, 1725, 10.1056/NEJM199912023412303 · DOI
  2. Goldberg, 2017, Trial of Transplantation of HCV-infected kidneys into uninfected recipients, N Engl J Med., 376, 2394, 10.1056/NEJMc1705221 · DOI
  3. Montgomery, 2011, Desensitization in HLA-incompatible kidney recipients and survival, N Engl J Med., 365, 318, 10.1056/NEJMoa1012376 · DOI
  4. Starzl, 1964, Renal heterotransplantation from baboon to man: experience with 6 cases, Transplantation., 2, 752, 10.1097/00007890-196411000-00009 · DOI
  5. Kuwaki, 2005, Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience, Nat Med., 11, 29, 10.1038/nm1171 · DOI
  6. Phelps, 2003, Production of alpha 1,3-galactosyltransferase-deficient pigs, Science., 299, 411, 10.1126/science.1078942 · DOI
  7. Yamada, 2005, Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue, Nat Med., 11, 32, 10.1038/nm1172 · DOI
  8. Cooper, 2019, Justification of specific genetic modifications in pigs for clinical organ xenotransplantation, Xenotransplantation., 26, e12516, 10.1111/xen.12516 · DOI
  9. Niu, 2017, Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9, Science., 357, 1303, 10.1126/science.aan4187 · DOI · Paper page
  10. Yang, 2015, Genome-wide inactivation of porcine endogenous retroviruses (PERVs), Science., 350, 1101, 10.1126/science.aad1191 · DOI
  11. Parent, 2020, The ethics of testing and research of manufactured organs on brain-dead/recently deceased subjects, J Med Ethics., 46, 199, 10.1136/medethics-2019-105674 · DOI
  12. Wood, 2004, Care of the potential organ donor, N Engl J Med., 351, 2730, 10.1056/NEJMra013103 · DOI
  13. Yamamoto, 2019, Life-supporting kidney xenotransplantation from genetically engineered pigs in baboons: a comparison of two immunosuppressive regimens, Transplantation., 103, 2090, 10.1097/TP.0000000000002796 · DOI
  14. Díaz Varela, 2003, Cross-reactivity between swine leukocyte antigen and human anti-HLA-specific antibodies in sensitized patients awaiting renal transplantation, J Am Soc Nephrol., 14, 2677, 10.1097/01.ASN.0000088723.07259.CF · DOI
  15. Taylor, 1998, HLA-specific antibodies in highly sensitized patients can cause a positive crossmatch against pig lymphocytes, Transplantation., 65, 1634, 10.1097/00007890-199806270-00016 · DOI
  16. Martens, 2017, Humoral reactivity of renal transplant-waitlisted patients to cells from GGTA1/CMAH/B4GalNT2, and SLA class I knockout pigs, Transplantation., 101, e86, 10.1097/TP.0000000000001646 · DOI
  17. Ladowski, 2018, Swine leukocyte antigen class II is a xenoantigen, Transplantation., 102, 249, 10.1097/TP.0000000000001924 · DOI
  18. Lunney, 2009, Molecular genetics of the swine major histocompatibility complex, the SLA complex, Dev Comp Immunol., 33, 362, 10.1016/j.dci.2008.07.002 · DOI
  19. Smith, 2005, Nomenclature for factors of the SLA class-I system, 2004, Tissue Antigens., 65, 136, 10.1111/j.1399-0039.2005.00337.x · DOI
  20. Smith, 2005, Nomenclature for factors of the swine leukocyte antigen class II system, 2005, Tissue Antigens., 66, 623, 10.1111/j.1399-0039.2005.00492.x · DOI
  21. Kaulitz, 2011, Development of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs, J Virol Methods., 175, 60, 10.1016/j.jviromet.2011.04.017 · DOI
  22. Kono, 2020, A highly sensitive method for the detection of recombinant PERV-A/C env RNA using next generation sequencing technologies, Sci Rep., 10, 21935, 10.1038/s41598-020-78890-2 · DOI
  23. Wynyard, 2014, Microbiological safety of the first clinical pig islet xenotransplantation trial in New Zealand, Xenotransplantation., 21, 309, 10.1111/xen.12102 · DOI
  24. Matsumoto, 2020, Long-term follow-up for the microbiological safety of clinical microencapsulated neonatal porcine islet transplantation, Xenotransplantation., 27, e12631, 10.1111/xen.12631 · DOI
  25. Denner, 2018, Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?, Retrovirology., 15, 28, 10.1186/s12977-018-0411-8 · DOI
  26. Poppelaars, 2017, Complement-mediated inflammation and injury in brain dead organ donors, Mol Immunol., 84, 77, 10.1016/j.molimm.2016.11.004 · DOI
  27. Shimizu, 2012, Pathologic characteristics of transplanted kidney xenografts, J Am Soc Nephrol., 23, 225, 10.1681/ASN.2011040429 · DOI
  28. Hillmen, 2006, The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria, N Engl J Med., 355, 1233, 10.1056/NEJMoa061648 · DOI
  29. Locke, 2009, The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection, Am J Transplant., 9, 231, 10.1111/j.1600-6143.2008.02451.x · DOI
  30. Orandi, 2014, Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection after HLA-incompatible kidney transplantation, Transplantation., 98, 857, 10.1097/TP.0000000000000298 · DOI
  31. Adams, 2021, Anti-C5 antibody tesidolumab reduces early antibody-mediated rejection and prolongs survival in renal xenotransplantation, Ann Surg., 274, 473, 10.1097/SLA.0000000000004996 · DOI · Paper page

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Metadata

Authors
Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld-Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., Stegner, K. L., Dandro, A., Kokkinaki, M., Kuravi, K. V., Reed, R. D., Fatima, H., Killian, J. T., Baker, G., Perry, J., Wright, E. D., Cheung, M. D., Erman, E. N., Kraebber, K., Gamblin, T., Guy, L., George, J. F., Ayares, D., & Locke, J. E.
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2022-04
Volume
22
Issue
4
Pages
1037-1053
ISSN
1600-6135
DOI
10.1111/ajt.16930
Cited by
417
References
1
Language
en
Licence
Funders
United Therapeutics Corporation

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