The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
Abstract
Taking the PERVs out of pigs: With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans. The challenge is that the pig genome harbors porcine endogenous retroviruses (PERVs) that can potentially pass to humans with possibly damaging consequences. Niu et al. generated pigs in which all copies of PERVs were inactivated by CRISPR-Cas9 genome engineering (see the Perspective by Denner). Not only does this work provide insights into PERV activity, but it also opens the door to a safer source of organs and tissues for pig-to-human xenotransplantation. Science , this issue p. 1303 ; see also p. 1238
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The donors carried porcine endogenous retrovirus (PERV) sequences in their genome, which present a zoonotic risk, as PERV transmission to human cells in culture and their integration into the human genome have been demonstrated.
“Third, the donors carried porcine endogenous retrovirus (PERV) sequences in their genome, which present a zoonotic risk, as PERV transmission to human cells in culture and their integration into the human genome have been demonstrated11,12.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [11]
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Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA)
Güell, M., Yang, L., & Church, G. M. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu427 · Cited by 142
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Research works printed but not linked: 14
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Design and testing of a humanized porcine donor for xenotransplantation
Anand, R. P., Layer, J. V., Heja, D., Hirose, T., Lassiter, G., Firl, D. J., Paragas, V. B., Akkad, A., Chhangawala, S., Colvin, R. B., et al. (2023) · Nature · doi:10.1038/s41586-023-06594-4 · Cited by 302
Self-citationTransplanting organs from pigs to humans
Sykes, M., & Sachs, D. H. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6298 · Cited by 191
Wang, X., Maxwell, K. G., Wang, K., Bowers, D. T., Flanders, J. A., Liu, W., Wang, L.-H., Liu, Q., Liu, C., Naji, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4601 · Cited by 119
Self-citationHDAC inhibitors support long-term expansion of porcine hepatocytes in vitro
Li, G., Zeng, M., Yan, Z., Cai, S., Ma, Y., Wang, Y., Li, S., Li, Y., Zhong, K., Xiao, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116973 · Cited by 2
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Metadata
- Authors
- Niu, D., Wei, H.-J., Lin, L., George, H., Wang, T., Lee, I.-H., Zhao, H.-Y., Wang, Y., Kan, Y., Shrock, E., Lesha, E., Wang, G., Luo, Y., Qing, Y., Jiao, D., Zhao, H., Zhou, X., Wang, S., Wei, H., Güell, M., Church, G. M., & Yang, L.
- Venue
- Science
- Published
- 2017-09-22
- Volume
- 357
- Issue
- 6357
- Pages
- 1303-1307
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC5813284
- Cited by
- 717
- References
- 1
- Language
- en
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