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Profilin as a severe food allergen in allergic patients overexposed to grass pollen

Alvarado, M. I., Jimeno, L., De La Torre, F., Boissy, P., Rivas, B., Lázaro, M. J., Barber, D.·2014·Allergy
DOI 10.1111/all.12509
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Abstract

Background Profilins are ubiquitous proteins that act as panallergens in sensitized patients, considered to be mild or incomplete food allergens. The aim of the study was to evaluate the role of profilins as severe food allergens in allergic patients overexposed to grass who were referred for severe food reactions and were sensitized to profilins. Methods After a careful in vitro screening, 26 patients were included, classified into two groups, mild (17) and severe reactors (9), based on clinical history and subsequently provoked orally with purified profilin in a double-blind placebo-controlled food challenge setup. Results A significant number of patients presented severe positive food challenge test reactions at low doses of the allergen profilin. Patients prone to suffer from severe reactions had lower IgG4/IgE ratio to major grass allergens than those who did not. Conclusion Profilins are complete food allergens in food-allergic patient populations that are exposed to high levels of grass pollen. This type of patient constitutes an optimal model to understand the link between respiratory and food allergies. The nature of the observed reactions and the low level of allergen eliciting the reactions suggest that intake through the oral mucosa might constitute a relevant route of exposure to food allergens.

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Research works printed but not linked: 23

  1. Carlsson, 1977, Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells, J Mol Biol, 115, 465, 10.1016/0022-2836(77)90166-8 · DOI
  2. Valenta, 1991, Identification of profilin as a novel pollen allergen: IgE autoreactivity in sensitized individuals, Science, 253, 557, 10.1126/science.1857985 · DOI
  3. Santos, 2011, Profilins: mimickers of allergy or relevant allergens?, Int Arch Allergy Immunol, 155, 191, 10.1159/000321178 · DOI
  4. Asero, 2008, Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen, Clin Exp Allergy, 38, 1033, 10.1111/j.1365-2222.2008.02980.x · DOI
  5. Asero, 2010, Preliminary results of a skin prick test-based study of the prevalence and clinical impact of hypersensitivity to pollen panallergen (polcalcin and profilin), J Investig Allergol Clin Immunol, 20, 35
  6. Barber, 2009, Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens, Clin Exp Allergy, 39, 1764, 10.1111/j.1365-2222.2009.03351.x · DOI
  7. Núñez, 2012, Profilin as a aeroallergen by means of conjunctival allergen challenge with purified date palm profilin, Int Arch Allergy Immunol, 158, 115, 10.1159/000330822 · DOI
  8. Ruiz-García, 2011, Profilin: a relevant aeroallergen?, J Allergy Clin Immunol, 128, 416, 10.1016/j.jaci.2011.03.008 · DOI
  9. Scheurer, 2004, Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion, J Allergy Clin Immunol, 114, 900, 10.1016/j.jaci.2004.06.017 · DOI
  10. Barber, 2008, Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study, Allergy, 63, 1550, 10.1111/j.1398-9995.2008.01807.x · DOI
  11. Barber, 2007, Degree of olive pollen exposure and sensitization patterns. Clinical Implications, J Investig Allergol Clin Immunol, 17, 11
  12. Rodríguez-Pérez, 2003, Profilin is a relevant melon allergen susceptible to pepsin digestion in patients with oral allergy syndrome, J Allergy Clin Immunol, 111, 634, 10.1067/mai.2003.74 · DOI
  13. López-Torrejón, 2005, Allergenic reactivity of the melon profilin Cuc m 2 and its identification as major allergen, Clin Exp Allergy, 35, 1065, 10.1111/j.1365-2222.2005.02303.x · DOI
  14. Ortolani, 1988, The oral allergy syndrome, Ann Allergy, 61, 47
  15. Bindslev-Jensen, 2004, Standardization of food challenges in patients with immediate reactions to foods - position paper from the European Academy of Allergology and Clinical Immunology, Allergy, 59, 690, 10.1111/j.1398-9995.2004.00466.x · DOI
  16. Cuesta-Herranz, 2010, Differences among pollen-allergic patients with and without plant food allergy, Int Arch Allergy Immunol, 153, 182, 10.1159/000312636 · DOI
  17. Salcedo, 2007, Plant non-specific lipid transfer proteins: an interface between plant defense and human allergy, Biochim Biophys Acta, 1771, 781, 10.1016/j.bbalip.2007.01.001 · DOI
  18. Joenvaara, 2009, Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients, J Allergy Clin Immunol, 124, 135, 10.1016/j.jaci.2008.11.048 · DOI
  19. Mattila, 2011, Allergy as an epithelial barrier disease, Clin Transl Allergy, 10, 1
  20. Hardymann, 2013, TNF-alpha mediated bronchial barrier disruption regulation by src-family kinase activation, J Allergy Clin Immunol, 132, 665, 10.1016/j.jaci.2013.03.005 · DOI
  21. Blume, 2013, Barrier responses of human bronchial epithelial cells to grass pollen exposure, Eur Respir J, 42, 87, 10.1183/09031936.00075612 · DOI
  22. Xiao, 2011, Defective epithelial barrier function in asthma, J Allergy Clin Immunol, 128, 549, 10.1016/j.jaci.2011.05.038 · DOI
  23. Christensen, 2008, Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge, J Allergy Clin Immunol, 122, 298, 10.1016/j.jaci.2008.05.026 · DOI

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Metadata

Authors
Alvarado, M. I., Jimeno, L., De La Torre, F., Boissy, P., Rivas, B., Lázaro, M. J., & Barber, D.
Affiliations
  • Servicio de Alergia; Hospital Ciudad de Coria; Coria Spain
  • Departamento de I+D y Medical Advisor; ALK-Abelló S.A.; Madrid Spain
  • Institute for Applied Molecular Medicine (IMMA); School of Medicine; University San Pablo-CEU; Madrid Spain
Venue
Allergy
Publisher
Wiley
Published
2014-10-03
Volume
69
Issue
12
Pages
1610-1616
ISSN
0105-4538
DOI
10.1111/all.12509
Cited by
83
References
0
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 333 d)
Funders
ALK-Abello S.A.

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