Cited by 96Asthma and respiratory diseasesAllergic Rhinitis and SensitizationMeta-analysis and systematic reviews

Overview of systematic reviews in allergy epidemiology

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Genuneit, J., Seibold, A. M., Apfelbacher, C. J., Konstantinou, G. N., Koplin, J. J., La Grutta, S., Logan, K., Perkin, M. R. +2 more·2017·Allergy

Abstract

Background: There is a substantial body of evidence on the epidemiology of allergic conditions, which has advanced the understanding of these conditions. We aimed to systematically identify systematic reviews and meta‐analyses on the epidemiology of allergic diseases to assess what has been studied comprehensively and what areas might benefit from further research. Methods: We searched PubMed and EMBASE up to 12/2014 for systematic reviews on epidemiological research on allergic diseases. We indexed diseases and topics covered and extracted data on the search characteristics of each systematic review. Results: The search resulted in 3991 entries after removing duplicates, plus 20 other items found via references and conference abstracts; 421 systematic reviews were relevant and included in this overview. The majority contained some evidence on asthma (72.9%). Allergic rhinitis, atopic eczema and food hypersensitivity were covered in 15.7%, 24.5% and 9.0%, respectively. Commonly studied risk factors for atopic eczema included dietary and microbial factors, while for asthma, pollution and genetic factors were often investigated in systematic reviews. There was some indication of differing search characteristics across topics. Conclusion: We present a comprehensive overview with an indexed database of published systematic reviews in allergy epidemiology. We believe that this clarifies where most research interest has focussed and which areas could benefit from further research. We propose that this effort is updated every few years to include the most recently published evidence and to extend the search to an even broader list of hypersensitivity/allergic disorders.

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  • The upper and lower airways are linked anatomically, histologically, and immunologically, with inflammation in one part influencing the other, forming a united airway system.

    “The upper and lower airways are linked from anatomical, histological, and immunological perspectives with inflammation in one part of the airways influencing the other part, thus forming a united airway system.336”

    From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [336]

    The Results discuss how often systematic reviews cover asthma and allergic rhinitis, and the Discussion describes the scope of the overview. Neither addresses anatomical, histological, or immunological links between the upper and lower airways or inflammation passing between them (searched: united airway, upper and lower airways, and rhinitis–asthma inflammation). (LLM, conf=0.76)

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Authors
Genuneit, J., Seibold, A. M., Apfelbacher, C. J., Konstantinou, G. N., Koplin, J. J., La Grutta, S., Logan, K., Perkin, M. R., Flohr, C., & the Task Force ‘Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)’ of the EAACI Interest Group on Epidemiology
Affiliations
  • Universität Ulm (DE)
  • University of Regensburg (DE)
  • Department of Allergy and Clinical Immunology 424 General Military Training Hospital Thessaloniki Greece
  • The University of Melbourne (AU)
  • National Research Council of Italy Institute of Biomedicine and Molecular Immunology Palermo Italy
  • King's College London (GB)
  • University of London (GB)
Corresponding author
Genuneit, J.
Venue
Allergy
Publisher
Wiley
Published
2017-01-24
Volume
72
Issue
6
Pages
849-856
ISSN
  • 0105-4538 (ISSN-L)
  • 1398-9995
OpenAlex
W2571477237
Cited by
96
References
43
Citations by year
2026: 1 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 15 · 2021: 9 · 2020: 19 · 2019: 15 · 2018: 8 · 2017: 6
FWCI
1.61
Type
journal article
Language
en
Open access
Locations
  • Allergy (publishedVersion)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
European Academy of Allergy and Clinical Immunology (EAACI)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Keywords
allergy epidemiology, allergic diseases, meta-analysis, asthma, allergic rhinitis, atopic dermatitis, food allergy, risk factors, research gaps
MeSH terms
Asthma, Dermatitis, Atopic, Food Hypersensitivity, Humans, Hypersensitivity, Review Literature as Topic, Rhinitis, Allergic

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