The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta‐analysis
Open accessAbstract
Background: The European Academy of Allergy and Clinical Immunology ( EAACI ) is in the process of developing Guidelines on Allergen Immunotherapy ( AIT ) for Allergic Rhinoconjunctivitis. To inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost‐effectiveness, and safety of AIT in the management of allergic rhinoconjunctivitis. Methods: We searched nine international biomedical databases for published, in‐progress, and unpublished evidence. Studies were independently screened by two reviewers against predefined eligibility criteria and critically appraised using established instruments. Our primary outcomes of interest were symptom, medication, and combined symptom and medication scores. Secondary outcomes of interest included cost‐effectiveness and safety. Data were descriptively summarized and then quantitatively synthesized using random‐effects meta‐analyses. Results: We identified 5960 studies of which 160 studies satisfied our eligibility criteria. There was a substantial body of evidence demonstrating significant reductions in standardized mean differences ( SMD ) of symptom ( SMD −0.53, 95% CI −0.63, −0.42), medication ( SMD −0.37, 95% CI −0.49, −0.26), and combined symptom and medication ( SMD −0.49, 95% CI −0.69, −0.30) scores while on treatment that were robust to prespecified sensitivity analyses. There was in comparison a more modest body of evidence on effectiveness post‐discontinuation of AIT , suggesting a benefit in relation to symptom scores. Conclusions: AIT is effective in improving symptom, medication, and combined symptom and medication scores in patients with allergic rhinoconjunctivitis while on treatment, and there is some evidence suggesting that these benefits are maintained in relation to symptom scores after discontinuation of therapy.
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EAACI Guidelines on Allergen Immunotherapy: Allergic Rhinoconjunctivitis
Roberts, G., Pfaar, O., Akdis, C. A., Ansotegui, I. J., Durham, S. R., Gerth van Wijk, R., Halken, S., Larenas‐Linnemann, D., Pawankar, R., Pitsios, C., et al. (2018) · Allergy · doi:10.1111/all.13317 · Cited by 702
Self-citationAkdis (2020) · doi:10.1111/pai.13189 · Cited by 320
Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation
Sahiner, U. M., Giovannini, M., Escribese, M. M., Paoletti, G., Heffler, E., Alvaro Lozano, M., Barber, D., Canonica, G. W., & Pfaar, O. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13050845 · Cited by 66
Self-citationBergmann, K.-C., Raab, J., Krause, L., Becker, S., Kugler, S., Zuberbier, T., Roth-Walter, F., Jensen-Jarolim, E., Kramer, M. F., & Graessel, A. (2022) · Allergo Journal International · doi:10.1007/s40629-021-00197-z · Cited by 12
Metadata
- Authors
- Dhami, S., Nurmatov, U., Arasi, S., Khan, T., Asaria, M., Zaman, H., Agarwal, A., Netuveli, G., Roberts, G., Pfaar, O., Muraro, A., Ansotegui, I. J., Calderon, M., Cingi, C., Durham, S., van Wijk, R. G., Halken, S., Hamelmann, E., Hellings, P., Jacobsen, L., Knol, E., Larenas‐Linnemann, D., Lin, S., Maggina, P., Mösges, R., Oude Elberink, H., Pajno, G., Panwankar, R., Pastorello, E., Penagos, M., Pitsios, C., Rotiroti, G., Timmermans, F., Tsilochristou, O., Varga, E. ‐., Schmidt‐Weber, C., Wilkinson, J., Williams, A., Worm, M., Zhang, L., & Sheikh, A.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2017-07-14
- Volume
- 72
- Issue
- 11
- Pages
- 1597-1631
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2614031938
- Cited by
- 369
- References
- 180
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dhami, S., Nurmatov, U., Arasi, S., Khan, T., Asaria, M., Zaman, H., Agarwal, A., Netuveli, G., Roberts, G., Pfaar, O., Muraro, A., Ansotegui, I. J., Calderon, M., Cingi, C., Durham, S., van Wijk, R. G., Halken, S., Hamelmann, E., Hellings, P., . . . Sheikh, A. (2017). Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta‐analysis. Allergy. https://doi.org/10.1111/all.13201
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
