The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
The role of allergen‐specific IgE, IgG and IgA in allergic disease
Open accessAbstract
Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals. This is termed allergic sensitization, which occurs mainly in early childhood. Allergen‐specific IgE then binds to the high (FcεRI) and low‐affinity receptors (FcεRII, also called CD23) for IgE on effector cells and antigen‐presenting cells. Subsequent and repeated allergen exposure increases allergen‐specific IgE levels and, by receptor cross‐linking, triggers immediate release of inflammatory mediators from mast cells and basophils whereas IgE‐facilitated allergen presentation perpetuates T cell–mediated allergic inflammation. Due to engagement of receptors which are highly selective for IgE, even tiny amounts of allergens can induce massive inflammation. Naturally occurring allergen‐specific IgG and IgA antibodies usually recognize different epitopes on allergens compared with IgE and do not efficiently interfere with allergen‐induced inflammation. However, IgG and IgA antibodies to these important IgE epitopes can be induced by allergen‐specific immunotherapy or by passive immunization. These will lead to competition with IgE for binding with the allergen and prevent allergic responses. Similarly, anti‐IgE treatment does the same by preventing IgE from binding to its receptor on mast cells and basophils. Here, we review the complex interplay of allergen‐specific IgE, IgG and IgA and the corresponding cell receptors in allergic diseases and its relevance for diagnosis, treatment and prevention of allergy.
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Cited by
Kato, Y., Morikawa, T., & Fujieda, S. (2025) · Allergology International · doi:10.1016/j.alit.2024.08.007 · Cited by 45
Environmental influences on childhood asthma: allergens
Custovic, A., de Moira, A. P., Murray, C. S., & Simpson, A. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.13915 · Cited by 37
The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses
Scheurer, S., Junker, A.-C., He, C., Schülke, S., & Toda, M. (2023) · Current Allergy and Asthma Reports · doi:10.1007/s11882-023-01105-x · Cited by 33
A Systematic Review of Allergen Cross-Reactivity: Translating Basic Concepts into Clinical Relevance
Sharma, E., & Vitte, J. (2024) · Journal of Allergy and Clinical Immunology: Global · doi:10.1016/j.jacig.2024.100230 · Cited by 31
Kedar, O., Golberg, A., Obolski, U., & Confino‐Cohen, R. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13300 · Cited by 27
Metadata
- Authors
- Shamji, M. H., Valenta, R., Jardetzky, T., Verhasselt, V., Durham, S. R., Würtzen, P. A., & van Neerven, R. J. J.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2021-06-08
- Volume
- 76
- Issue
- 12
- Pages
- 3627-3641
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W3160325999
- Cited by
- 336
- References
- 166
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shamji, M. H., Valenta, R., Jardetzky, T., Verhasselt, V., Durham, S. R., Würtzen, P. A., & van Neerven, R. J. J. (2021). The role of allergen‐specific IgE, IgG and IgA in allergic disease. Allergy. https://doi.org/10.1111/all.14908
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