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The neurovascular unit - concept review
Abstract
The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in satisfactory levels, through vasodilation and vasoconstriction. The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), myocytes, pericytes and extracellular matrix components. These cells, through their intimate anatomical and chemical relationship, detect the needs of neuronal supply and trigger necessary responses (vasodilation or vasoconstriction) for such demands. Here, we review the concepts of NVU, the coupling mechanisms and research strategies.
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“Astrocytes, microglia, and endothelial cells establish tightly articulated physical and molecular interactions [1, 2, 3, 4] in a functionally integrated structure known as the gliovascular unit (GVU) [5] through which many of the properties of the brain are maintained [3, 4].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection (2023) · cites this paper as [3]
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“The integrity of the GVU relies on astrocyte morphological and functional stability [2, 3, 17].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection (2023) · cites this paper as [3]
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Metadata
- Authors
- Muoio, V., Persson, P. B., & Sendeski, M. M.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Muoio, V.
- ORCID
- Persson, P. B.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2014-03-14
- Volume
- 210
- Issue
- 4
- Pages
- 790-798
- ISSN
- 1748-1708 (ISSN-L)
- OpenAlex
- W2087356761
- Cited by
- 564
- References
- 93
- Citations by year
- 2026: 40 · 2025: 30 · 2024: 63 · 2023: 61 · 2022: 75 · 2021: 79 · 2020: 63 · 2019: 44 · 2018: 47 · 2017: 28 · 2016: 17 · 2015: 11 · 2014: 5
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neurovascular unit, neurovascular coupling, brain homeostasis, vasodilation, vasoconstriction, blood-brain barrier, astrocytes, pericytes, endothelial cells, muscle cells, extracellular matrix
- MeSH terms
- Astrocytes, Blood Vessels, Brain, Homeostasis, Humans, Signal Transduction
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