Cited by 564Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular DisturbancesNeuroscience and Neuropharmacology Research

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The neurovascular unit - concept review

Muoio, V., Persson, P. B., Sendeski, M. M.·2014·Acta Physiologica

DOI 10.1111/apha.12250

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Abstract

The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in satisfactory levels, through vasodilation and vasoconstriction. The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), myocytes, pericytes and extracellular matrix components. These cells, through their intimate anatomical and chemical relationship, detect the needs of neuronal supply and trigger necessary responses (vasodilation or vasoconstriction) for such demands. Here, we review the concepts of NVU, the coupling mechanisms and research strategies.

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Authors: Muoio, V., Persson, P. B., & Sendeski, M. M.
Affiliations: Charité – Universitätsmedizin Berlin (DE)
Corresponding author: Muoio, V.
ORCID: Persson, P. B.
Venue: Acta Physiologica
Publisher: Wiley
Published: 2014-03-14
Volume: 210
Issue: 4
Pages: 790-798
ISSN: 1748-1708 (ISSN-L)
DOI: 10.1111/apha.12250
OpenAlex: W2087356761
Cited by: 564
References: 93
Citations by year: 2026: 40 · 2025: 30 · 2024: 63 · 2023: 61 · 2022: 75 · 2021: 79 · 2020: 63 · 2019: 44 · 2018: 47 · 2017: 28 · 2016: 17 · 2015: 11 · 2014: 5
FWCI: 1.65
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 536 d)
Locations: Acta Physiologica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurovascular unit, neurovascular coupling, brain homeostasis, vasodilation, vasoconstriction, blood-brain barrier, astrocytes, pericytes, endothelial cells, muscle cells, extracellular matrix
MeSH terms: Astrocytes, Blood Vessels, Brain, Homeostasis, Humans, Signal Transduction

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