The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Effects of shear stress on endothelial cells: go with the flow
Abstract
Haemodynamic forces influence the functional properties of vascular endothelium. Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit mechanical signals through mechanosensitive signalling pathways to recipient molecules that lead to phenotypic and functional changes. Arterial architecture varies greatly exhibiting bifurcations, branch points and curved regions, which are exposed to various flow patterns. Clinical studies showed that atherosclerotic plaques develop preferentially at arterial branches and curvatures, that is in the regions exposed to disturbed flow and shear stress. In the atheroprone regions, the endothelium has a proinflammatory phenotype associated with low nitric oxide production, reduced barrier function and increased proadhesive, procoagulant and proproliferative properties. Atheroresistant regions are exposed to laminar flow and high shear stress that induce prosurvival antioxidant signals and maintain the quiescent phenotype in ECs. Indeed, various flow patterns contribute to phenotypic and functional heterogeneity of arterial endothelium whose response to proatherogenic stimuli is differentiated. This may explain the preferential development of endothelial dysfunction in arterial sites with disturbed flow.
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RETRACTED: Endothelial PECAM-1 and its function in vascular physiology and atherogenic pathology
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Epigenetic modifications and human disease
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Pathophysiology of Atherosclerosis
Jebari-Benslaiman, S., Galicia-García, U., Larrea-Sebal, A., Olaetxea, J. R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., & Martín, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063346 · Cited by 1,010
Lourenço, C. F., & Laranjinha, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.729201 · Cited by 85
Liu, Y., Kamran, R., Han, X., Wang, M., Li, Q., Lai, D., Naruse, K., & Takahashi, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-68275-0 · Cited by 47
Jiménez-Torres, J. A., Virumbrales-Muñoz, M., Sung, K. E., Lee, M. H., Abel, E. J., & Beebe, D. J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.026 · Cited by 46
Metadata
- Authors
- Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2016-06-19
- Volume
- 219
- Issue
- 2
- Pages
- 382-408
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W2417375737
- Cited by
- 431
- References
- 236
- FWCI
- 16.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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