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Cited by 44Ion Transport and Channel RegulationRedox biology and oxidative stressRenal function and acid-base balance

Role of SLC4 and SLC26 solute carriers during oxidative stress

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Remigante, Alessia, Spinelli, Sara, Pusch, Michael, Sarikas, Antonio, Morabito, Rossana, Marino, Angela, Dossena, Silvia·2022·Acta Physiologica
DOI 10.1111/apha.13796PMC PMC9542443
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Abstract

Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by various exchangers to transport other ions and organic substrates across cell membranes and plays a critical role in cell and systemic pH homoeostasis. Chloride/bicarbonate (Cl−/HCO 3−) exchangers are abundantly expressed in erythrocytes and epithelial cells and, as a consequence, are particularly exposed to oxidants in the systemic circulation and at the interface with the external environment. Here, we review the physiological functions and pathophysiological alterations of Cl−/HCO 3− exchangers belonging to the solute carriers SLC4 and SLC26 superfamilies in relation to oxidative stress. Particularly well studied is the impact of oxidative stress on the red blood cell SLC4A1/AE1 (Band 3 protein), of which the function seems to be directly affected by oxidative stress and possibly involves oxidation of the transporter itself or its interacting proteins, with detrimental consequences in oxidative stress‐related diseases including inflammation, metabolic dysfunctions and ageing. The effect of oxidative stress on SLC26 members was less extensively explored. Indirect evidence suggests that SLC26 transporters can be target as well as determinants of oxidative stress, especially when their expression is abolished or dysregulated.

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  • SLC4A1 regulates peripheral pH and redox buffering, and its loss has been linked to oxidative stress and neurodegeneration.

    “Of note, SLC4A1 regulates peripheral pH and redox buffering, and its loss has been linked to oxidative stress and neurodegeneration, 62 , 63 suggesting that its enrichment in APOE3Ch ‐EVs may support endothelial resilience.”

    From Plasma extracellular vesicles from <i>APOE3</i> Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease (2026) · cites this paper as [62]

    The SLC4A1 isoform section describes bicarbonate exchange in peripheral tissues, supporting a role in pH regulation, and reports oxidative-stress-related changes in band 3 function. Its ageing subsection reports accelerated band 3 breakdown in people with Alzheimer’s disease. It does not establish that SLC4A1 provides redox buffering or that its loss contributes to neurodegeneration. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Remigante, A., Spinelli, S., Pusch, M., Sarikas, A., Morabito, R., Marino, A., & Dossena, S.
Affiliations
  • University of Messina (IT)
  • National Research Council (IT)
  • Paracelsus Medical University (AT)
Corresponding author
Dossena, Silvia
ORCID
Venue
Acta Physiologica
Publisher
Wiley
Published
2022-03
Volume
235
Issue
1
Pages
e13796-e13796
ISSN
  • 1748-1708 (ISSN-L)
  • 1748-1716
DOI
10.1111/apha.13796
PMC
PMC9542443
OpenAlex
W4211120933
Cited by
44
References
3
Citations by year
2026: 5 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 5
FWCI
1.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Physiologica (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Funders
Associazione Italiana per la Ricerca sul Cancro (# IG 21558)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
Keywords
solute carrier transporters, chloride/bicarbonate exchanger, oxidative stress, bicarbonate transport, pH homeostasis, erythrocyte band 3, epithelial cells, inflammation, aging, metabolic dysfunction
MeSH terms
Animals, Bicarbonates, Cell Membrane, Erythrocytes, Mammals, Oxidative Stress, Membrane Transport Proteins

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