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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Review article: Herbal hepatotoxicity--an update on traditional Chinese medicine preparations

Teschke, R., Wolff, A., Frenzel, C., Schulze, J.·2014·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.12798
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Abstract

Summary: Background: Although evidence for their therapeutic efficacy is limited, herbal traditional Chinese medicine ( TCM ) preparations increasingly gain popularity. In contrast to other herbal products, adverse effects by herbal TCM including liver toxicity were rarely reported. In recent years, more cases were published, providing new clinical challenges. Aim: To summarise comprehensively the literature on herbal TCM hepatotoxicity since 2011. Methods: PubMed was searched using key words related to TCM , the results were restricted to full English‐language publications and abstracts published since 2011. In addition, the database of the National Institutes of Health ( NIH ) and LiverTox was accessed under the topic ‘Drug record: Chinese and other Asian herbal medicines’. Results: Since 2011, new case reports and case series provided evidence for herbal hepatotoxicity by TCM , focusing on nine TCM herbal mixtures and four individual TCM herbs with potential health hazards. These were the TCM products Ban Tu Wan, Chai Hu, Du Huo, Huang Qin, Jia Wei Xia Yao San, Jiguja, Kamishoyosan, Long Dan Xie Gan Tang, Lu Cha, Polygonum multiflorum products, Shan Chi, ‘White flood’ containing the herbal TCM Wu Zhu Yu and Qian Ceng Ta, and Xiao Chai Hu Tang. Other developments include the establishment of a new and early diagnostic serum marker for hepatotoxicity caused by pyrrolizidine alkaloids, assessed using ultra performance liquid chromatography–mass spectrometry analysis, and new regulatory details to improve herbal TCM product quality and safety. Conclusion: Stringent evaluation of the risk/benefit ratio is essential to protect traditional Chinese medicines users from health hazards including liver injury.

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Crossref · 10.1111/apt.12798

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Research works printed but not linked: 29

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Metadata

Authors
Teschke, R., Wolff, A., Frenzel, C., & Schulze, J.
Affiliations
  • Department of Internal Medicine II Division of Gastroenterology and Hepatology Klinikum Hanau Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/Main Hanau Germany
  • Department of Internal Medicine II Division of Gastroenterology, Hepatology and Infectious Diseases Friedrich Schiller University Jena Jena Germany
  • Department of Medicine I University Medical Center Hamburg Eppendorf Hamburg Germany
  • Institute of Industrial, Environmental and Social Medicine Medical Faculty Goethe University Frankfurt/Main Frankfurt Germany
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2014-05-20
Volume
40
Issue
1
Pages
32-50
ISSN
  • 0269-2813
  • 1365-2036
DOI
10.1111/apt.12798
Cited by
130
References
2
Language
en
Licence

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