The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Systematic review with meta‐analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth
Open accessAbstract
Summary: Background: Small intestinal bacterial overgrowth (SIBO) is a heterogeneous syndrome, characterised by an increased number and/or abnormal type of bacteria in the small bowel. Over the past decades, rifaximin has gained popularity for this indication despite its use is not evidence based. Aim: To perform a systematic review and meta‐analysis to summarise evidence about the efficacy and safety of rifaximin to eradicate SIBO in adult patients. Methods: MEDLINE, EMBASE, CCRCT, Scopus and Web of Science were searched from inception to March 16, 2015 for RCT s and observational studies. Furthermore, abstract books of major European, American and Asian gastroenterological meetings were also examined. Results: Thirty‐two studies involving 1331 patients were included. The overall eradication rate according to intention‐to‐treat analysis was 70.8% (95% CI: 61.4–78.2; I2 = 89.4%) and to per protocol analysis 72.9% (95% CI: 65.5–79.8; I2 = 87.5%). Meta‐regression identified three covariates (drug dose, study design and co‐therapy) independently associated with an increased eradication rate. The overall rate of adverse events was 4.6% (95% CI: 2.3–7.5; I2 = 63.6%). In the subset of studies (n= 10) allowing the analysis, improvement or resolution of symptoms in patients with eradicated SIBO was found to be 67.7% (95% CI: 44.7–86.9; I2 = 91.3%). Conclusions: Rifaximin treatment seems to be effective and safe for the treatment of SIBO. However, the quality of the available studies is generally poor. Well‐designed RCT s are needed to substantiate these findings and to establish the optimal regimen.
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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
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BackgroundA comparison of observational studies and randomized, controlled trials.
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The gut microbiota and host health: a new clinical frontier
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Cited by
A review of studies on gut microbiota and levodopa metabolism
Zhong, Z., Ye, M., & Yan, F. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1046910 · Cited by 31
Is small intestinal bacterial overgrowth involved in the pathogenesis of functional dyspepsia?
Tziatzios, G., Giamarellos-Bourboulis, E. J., Papanikolaou, I. S., Pimentel, M., Dimitriadis, G. D., & Triantafyllou, K. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.07.005 · Cited by 30
Aetiology, diagnosis and management of small intestinal bacterial overgrowth
Ahmed, J. F., Padam, P., & Ruban, A. (2023) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102163 · Cited by 28
Chronic, Noninfectious Diarrhea: A Review
Singh, P., Lee, A., Sheth, N. M., & Chey, W. D. (2026) · JAMA · doi:10.1001/jama.2026.0872 · Cited by 13
Metadata
- Authors
- Gatta, L., & Scarpignato, C.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2017-01-12
- Volume
- 45
- Issue
- 5
- Pages
- 604-616
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2578484558
- Cited by
- 266
- References
- 19
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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