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Cited by 28Gastrointestinal motility and disordersGut microbiota and healthGastrointestinal Bleeding Diagnosis and Treatment

Aetiology, diagnosis and management of small intestinal bacterial overgrowth

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Ahmed, Jabed Foyez, Padam, Pritpal, Ruban, Aruchuna·2023·Frontline Gastroenterology
DOI 10.1136/flgastro-2022-102163PMC PMC9933597
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Abstract

Small intestinal bacterial overgrowth is a small bowel disorder characterised by excessive amounts of bacteria populating the small intestine leading to symptoms of abdominal pain, bloating and change in bowel habit. This creates some degree of diagnostic uncertainty due to the overlap of these symptoms with numerous other gastrointestinal conditions. Quantitative culture of jejunal aspirates is the gold standard diagnostic test but has largely been replaced by glucose and lactulose breath tests due to their relative ease and accessibility. The approach to treatment centres around reducing bacterial numbers through antibiotic therapy and managing any predisposing factors. Further research is required in order to define the optimum antibiotic choice and duration of therapy as well as the potential diagnostic utility of home breath testing and capsule-based technology.

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Cited by

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Authors
Ahmed, J. F., Padam, P., & Ruban, A.
Affiliations
Imperial College Healthcare NHS Trust (GB)
Corresponding author
Ahmed, Jabed Foyez
ORCID
Venue
Frontline Gastroenterology
Publisher
BMJ
Published
2022-07-12
Volume
14
Issue
2
Pages
149-154
ISSN
  • 2041-4137 (ISSN-L)
  • 2041-4145
DOI
10.1136/flgastro-2022-102163
PMC
PMC9933597
OpenAlex
W4285091608
Cited by
28
References
6
Citations by year
2026: 8 · 2025: 10 · 2024: 7 · 2023: 3
FWCI
4.37
Type
journal article
Language
en
Open access
Locations
  • Frontline Gastroenterology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords
small intestinal bacterial overgrowth, etiology, diagnosis, glucose breath test, lactulose breath test, antibiotic therapy, abdominal pain, bloating, altered bowel habits, capsule endoscopy

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