Ketamine‐induced inhibition of glycogen synthase kinase‐3 contributes to the augmentation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptor signaling
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Objectives: Sub‐anesthetic doses of ketamine have been found to provide rapid antidepressant actions, indicating that the cellular signaling systems targeted by ketamine are potential sites for therapeutic intervention. Ketamine acts as an antagonist of N‐methyl‐D‐aspartate (NMDA) receptors, and animal studies indicate that subsequent augmentation of signaling by α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptors is critical for the antidepressant outcome. Methods: In this study, we tested if the inhibitory effect of ketamine on glycogen synthase kinase‐3 (GSK 3) affected hippocampal cell‐surface AMPA receptors using immunoblotting of membrane and synaptosomal extracts from wild‐type and GSK 3 knockin mice. Results: Treatment with an antidepressant dose of ketamine increased the hippocampal membrane level of the AMPA glutamate receptor (GluA)1 subunit, but did not alter the localization of GluA2, GluA3, or GluA4. This effect of ketamine was abrogated in GSK 3 knockin mice expressing mutant GSK 3 that cannot be inhibited by ketamine, demonstrating that ketamine‐induced inhibition of GSK 3 is necessary for up‐regulation of cell surface AMPA GluA1 subunits. AMPA receptor trafficking is regulated by post‐synaptic density‐95 (PSD‐95), a substrate for GSK 3. Ketamine treatment decreased the hippocampal membrane level of phosphorylated PSD‐95 on Thr‐19, the target of GSK 3 that promotes AMPA receptor internalization. Conclusions: These results demonstrate that ketamine‐induced inhibition of GSK 3 causes reduced phosphorylation of PSD‐95, diminishing the internalization of AMPA GluA1 subunits to allow for augmented signaling through AMPA receptors following ketamine treatment.
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Ketamine may induce activation of mTOR by the upstream kinase Akt, regulate phosphorylation of GSK-3β, and exert antidepressant effects.
“Ketamine may induce the activation of mTOR by the upstream kinase Akt, regulate the phosphorylation of GSK-3β, and exert antidepressant effects. 380”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [380]
The Results report increased hippocampal phospho-mTOR after ketamine treatment and link that response to GSK3 inhibition. The Discussion reports ketamine-induced inhibitory phosphorylation of GSK3 and relates it to antidepressant effects. Neither passage identifies Akt as the upstream kinase responsible for mTOR activation; a search for Akt found no such mechanism in our copy. Page numbers are unavailable. (LLM, conf=0.88)
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
Beurel, E., Grieco, S. F., & Jope, R. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.016 · Cited by 1,768 · see citing works
Self-citationNMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Peineau, S., Taghibiglou, C., Bradley, C. A., Wong, T. P., Liu, L., Lu, J., Lo, E., Wu, D., Saule, E., Bouschet, T., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.029 · Cited by 691 · see citing works
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594 · see citing works
Koike, H., Iijima, M., & Chaki, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.035 · Cited by 346 · see citing works
Ketamine administration in depressive disorders: a systematic review and meta-analysis
Fond, G., Loundou, A., Rabu, C., Macgregor, A., Lançon, C., Brittner, M., Micoulaud-Franchi, J.-A., Richieri, R., Courtet, P., Abbar, M., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3664-5 · Cited by 339 · see citing works
Synaptic plasticity in depression: molecular, cellular and functional correlates.
Marsden, W. N. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 321 · see citing works
In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain
Li, X., Zhu, W., Roh, M.-S., Friedman, A. B., Rosborough, K., & Jope, R. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300439 · Cited by 300 · see citing works
Self-citationBeurel, E., Song, L., & Jope, R. S. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.47 · Cited by 288 · see citing works
Self-citationLiu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.128 · Cited by 256 · see citing works
Akt as a mediator of cell death
Luo, H. R., Hattori, H., Hossain, M. A., Hester, L. D., Huang, Y., Lee‐Kwon, W., Donowitz, M., Nagata, E., & Snyder, S. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1634990100 · Cited by 245 · see citing works
Polter, A., Beurel, E., Yang, S., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.43 · Cited by 225 · see citing works
Self-citationEnhanced Long-Term Synaptic Depression in an Animal Model of Depression
Holderbach, R., Clark, K., Moreau, J., Bischofberger, J., & Normann, C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.007 · Cited by 174 · see citing works
Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders
Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00016 · Cited by 174 · see citing works
Self-citationNiciu, M. J., Henter, I. D., Luckenbaugh, D. A., Zarate, C. A., & Charney, D. S. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135950 · Cited by 161 · see citing works
Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157 · see citing works
Nelson, C. D., Kim, M. J., Hsin, H., Chen, Y., & Sheng, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-13.2013 · Cited by 134 · see citing works
Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants
Abdallah, C. G., Averill, L. A., & Krystal, J. H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12718 · Cited by 121 · see citing works
A kinesin signaling complex mediates the ability of GSK-3β to affect mood-associated behaviors
Du, J., Wei, Y., Liu, L., Wang, Y., Khairova, R. A., Blumenthal, R., Tragon, T. R., Hunsberger, J. G., Machado‐Vieira, R., Drevets, W. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913138107 · Cited by 116 · see citing works
Zunszain, P. A., Horowitz, M. A., Cattaneo, A., Lupi, M., & Pariante, C. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.87 · Cited by 108 · see citing works
Gould, T. D., O’Donnell, K. C., Dow, E. R., Du, J., Chen, G., & Manji, H. K. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.11.002 · Cited by 103 · see citing works
Regulation of AMPA Receptor Trafficking and Function by Glycogen Synthase Kinase 3
Wei, J., Liu, W., & Yan, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121376 · Cited by 93 · see citing works
In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
Sarno, P. D., Bijur, G. N., Zmijewska, A. A., Li, X., & Jope, R. S. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.003 · Cited by 81 · see citing works
Self-citationChaouloff, F., Hémar, A., & Manzoni, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1150-07.2007 · Cited by 66 · see citing works
Chiu, C., Scheuing, L., Liu, G., Liao, H., Linares, G. R., Lin, D. H., & Chuang, D. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu102 · Cited by 66 · see citing works
Metaplastic Effects of Subanesthetic Ketamine on CA1 Hippocampal Function
Izumi, Y., & Zorumski, C. F. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.002 · Cited by 63 · see citing works
Zhu, W., Wang, S., Liu, M.-M., Shi, H., Zhang, R., Liu, J., Ding, Z., & Lü, L. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120228 · Cited by 62 · see citing works
Zheng, W., & Quirion, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807914200 · Cited by 56 · see citing works
Yang, C., Zhou, Z.-Q., Gao, Z.-Q., Shi, J.-Y., & Yang, J.-J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.022 · Cited by 55 · see citing works
Zhou, W., Dong, L., Wang, N., Shi, J., Yang, J., Zuo, Z., & Zhou, Z. (2014) · NeuroImmunoModulation · doi:10.1159/000356517 · Cited by 49 · see citing works
Seo, M. S., Kim, S. H., Ahn, Y.-M., Kim, Y., Jeon, W. J., Yoon, S. C., Roh, M., Juhnn, Y., & Kim, Y. S. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006869 · Cited by 40 · see citing works
MK-801 induces schizophrenic behaviors through downregulating Wnt signaling pathways in male mice
Yu, J., Qi, D., Xing, M., Li, R., Jiang, K., Peng, Y., & Cui, D. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.039 · Cited by 33 · see citing works
Rapid antidepressant effects: moving right along
Martinowich, K., Jimenez, D. V., Zarate, C. A., & Manji, H. K. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.55 · Cited by 32 · see citing works
Wang, M.-J., Li, Y., Snyder, M. A., Wang, H., Li, F., & Gao, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061787 · Cited by 32 · see citing works
Pignatelli, M., Vollmayr, B., Richter, S. H., Middei, S., Matrisciano, F., Molinaro, G., Nasca, C., Battaglia, G., Ammassari‐Teule, M., Feligioni, M., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.046 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works
“380 Ketamine can block NMDARs in postsynaptic principal neurons in the PFC and hippocampus, increase synaptic function through homeostatic mechanisms, and reverse synaptic defects caused by chronic stress.”
BackgroundTargeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482 · see citing works
Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications
Li, Z., Ruan, M., Chen, J., & Fang, Y. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00638-3 · Cited by 352 · see citing works
Ketamine: A tale of two enantiomers
Jelen, L. A., Young, A. H., & Stone, J. M. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959644 · Cited by 253 · see citing works
Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Grunebaum, M. F., Ellis, S. P., Keilp, J. G., Moitra, V. K., Cooper, T. B., Marver, J. E., Burke, A. K., Milak, M. S., Sublette, M. E., Oquendo, M. A., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12487 · Cited by 174 · see citing works
Convergent Mechanisms Underlying Rapid Antidepressant Action
Zanos, P., Thompson, S. M., Duman, R. S., Zarate, C. A., & Gould, T. D. (2018) · CNS Drugs · doi:10.1007/s40263-018-0492-x · Cited by 171 · see citing works
Neuropathology of suicide: Recent findings and future directions
Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works
Kohtala, S. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00232-4 · Cited by 146 · see citing works
The molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works
GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness
Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works
Ketamine: Neuroprotective or Neurotoxic?
Choudhury, D., Autry, A. E., Tolias, K. F., & Krishnan, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.672526 · Cited by 85 · see citing works
Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77 · see citing works
Jakaria, M., Park, S., Haque, M. E., Karthivashan, G., Kim, I., Ganesan, P., & Choi, D. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00307 · Cited by 70 · see citing works
Lullau, A. P. M., Haga, E. M. W., Ronold, E. H., & Dwyer, G. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223145 · Cited by 63 · see citing works
Kohtala, S., Theilmann, W., Rosenholm, M., Penna, L., Karabulut, G., Uusitalo, S., Järventausta, K., Yli‐Hankala, A., Yalçın, İ., Matsui, N., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1364-6 · Cited by 58 · see citing works
Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia
Grieco, S. F., Qiao, X., Zheng, X., Liu, Y., Chen, L., Zhang, H., Yu, Z., Gavornik, J. P., Lai, C., Gandhi, S. P., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.008 · Cited by 60 · see citing works
Self-citationKim, J., & Monteggia, L. M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112378 · Cited by 56 · see citing works
Chen, T., Cheng, L., Ma, J., Yuan, J., Pi, C., Xiong, L., Chen, J., Liu, H., Tang, J., Zhong, Y., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106837 · Cited by 55 · see citing works
Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S. V., & Rantamäki, T. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107741 · Cited by 46 · see citing works
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45 · see citing works
Li, Y., Li, X., Guo, C., Li, L., Wang, Y., Zhang, Y., Chen, Y., Liu, W., & Gao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16042 · Cited by 42 · see citing works
Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41 · see citing works
Ketamine: The final frontier or another depressing end?
Sial, O. K., Parise, E. M., Parise, L. F., Gnecco, T., & Bolaños‐Guzmán, C. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112508 · Cited by 40 · see citing works
Iaconelli, J., Xuan, L. L., & Karmacharya, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071605 · Cited by 37 · see citing works
van Calker, D., Serchov, T., Normann, C., & Biber, K. P. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.014 · Cited by 35 · see citing works
Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects
Fraga, D. B., Costa, A. P., Olescowicz, G., Camargo, A., Pazini, F. L., Freitas, A. E., Moretti, M., Brocardo, P. S., & Rodrigues, A. L. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109757 · Cited by 34 · see citing works
Zarate, C. A., & Machado‐Vieira, R. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.249 · Cited by 33 · see citing works
The role of serotonin neurotransmission in rapid antidepressant actions
Pehrson, A. L., Roberts, D., Khawaja, A., & McNair, R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06098-5 · Cited by 33 · see citing works
Björkholm, C., Marcus, M. M., Konradsson‐Geuken, Å., Jardemark, K. E., & Svensson, T. H. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.01.014 · Cited by 30 · see citing works
Neis, V. B., Bettio, L. E. B., Moretti, M., da Rosa, P. B., Olescowicz, G., Fraga, D. B., Gonçalves, F. M., Freitas, A. E., Heinrich, I. A., Lopes, M. W., et al. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.08.005 · Cited by 33 · see citing works
Viana, G. S. D. B., do Vale, E. M., de Araujo, A. R. A., Coelho, N. C., Andrade, S. M., da Costa, R. O., de Aquino, P. E. A., de Sousa, C. N. S., Medeiros, I. D. S., Vasconcelos, S. M. M., et al. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x202010107 · Cited by 30 · see citing works
Michaëlsson, H., Andersson, M., Svensson, J., Karlsson, L., Ehn, J., Culley, G. R., Engström, A., Bergström, N., Savvidi, P., Kuhn, H. G., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13211 · Cited by 29 · see citing works
GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
Albeely, A. M., Williams, O. O. F., & Perreault, M. L. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01020-z · Cited by 26 · see citing works
García-Pardo, M. P., Miñarro, J., Llansola, M., Felipo, V., & Aguilar, M. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14190 · Cited by 26 · see citing works
Shen, M., Lv, D., Liu, X., Li, S., Chen, Y., Zhang, Y., Wang, Z., & Wang, C. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.004 · Cited by 25 · see citing works
Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.749180 · Cited by 26 · see citing works
Manduca, J. D., Thériault, R.-K., & Perreault, M. L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104819 · Cited by 21 · see citing works
Inflammation Effects on Glutamate as a Pathway to Neuroprogression in Mood Disorders
Haroon, E., & Miller, A. H. (2017) · Modern trends in psychiatry · doi:10.1159/000470805 · Cited by 21 · see citing works
Preclinical models of treatment-resistant depression: challenges and perspectives
Kolasa, M., & Faron‐Górecka, A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00542-9 · Cited by 22 · see citing works
Kühn, M., Maier, J. G., Wolf, E., Mainberger, F., Feige, B., Maywald, S., Bredl, A., Michel, M., Sendelbach, N., Normann, C., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.08.052 · Cited by 20 · see citing works
Alozie, E. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608059768115010014 · Cited by 26 · see citing works
Zarate, C. A., & Machado‐Vieira, R. (2016) · Bipolar Disorders · doi:10.1111/bdi.12452 · Cited by 19 · see citing works
Peng, F., Fan, J., Ge, T., Liu, Q. Q., & Li, B. J. (2020) · Cell Proliferation · doi:10.1111/cpr.12804 · Cited by 18 · see citing works
Zhornitsky, S., Oliva, H. N. P., Jayne, L. A., Allsop, A. S., Kaye, A. P., Potenza, M. N., & Angarita, G. A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1197890 · Cited by 15 · see citing works
Li, Y., He, Y., Fan, H., Wang, Z., Huang, J. A., Wen, G., Wang, X., Xie, Q., & Qiu, P. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114740 · Cited by 14 · see citing works
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Alitalo, O., González-Hernández, G., Rosenholm, M., Kohtala, P., Matsui, N., Müller, H. K., Theilmann, W., Klein, A. B., Kärkkäinen, O. K., Rozov, S. V., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00350 · Cited by 13 · see citing works
Can, A., Mitchell, J., Dutton, M., Bennett, M. R., Hermens, D. F., & Lagopoulos, J. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13572 · Cited by 11 · see citing works
Neves, G. A., Borsoï, M., Antonio, C. B., Pranke, M. A., Betti, A. H., & Rates, S. M. K. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160844 · Cited by 11 · see citing works
Domingos, L. B., Müller, H. K., da Silva, N. R., Filiou, M. D., Nielsen, A. L., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109870 · Cited by 10 · see citing works
Alitalo, O., Kohtala, S., Rosenholm, M., Saarreharju, R., González-Hernández, G., Sarparanta, M. P., Rozov, S. V., & Rantamäki, T. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110172 · Cited by 10 · see citing works
Shen, M., Lv, D., Li, S., Zhang, Y., Wang, Z., Zhao, C., Chen, X., & Wang, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy324 · Cited by 10 · see citing works
Hladik, D., Buratovic, S., von Toerne, C., Azimzadeh, O., Subedi, P., Philipp, J., Winkler, S., Feuchtinger, A., Samson, E., Hauck, S. M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236103 · Cited by 10 · see citing works
Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions
Olivero, G., Grilli, M., Marchi, M., & Pittaluga, A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109570 · Cited by 10 · see citing works
The Wnt signaling pathway in major depressive disorder: A systematic review of human studies
Sánchez-Ruiz, J. A., Treviño‐Alvarez, A. M., Zambrano-Lucio, M., Lozano-Díaz, S. T., Wang, N., Biernacka, J. M., Tye, S. J., & Barboza, A. B. C. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115983 · Cited by 9 · see citing works
Castanheira, S., Gomes, C. V., Bicker, J., & Fortuna, A. C. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104371 · Cited by 9 · see citing works
The Future of Psychoneuroimmunology: Promises and Challenges
Halaris, A. E., Bechter, K., Haroon, E., Leonard, B. E., Miller, A. H., Pariante, C. M., & Zunszain, P. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-70554-5_15 · Cited by 9 · see citing works
Why is lithium effective in alleviating bipolar disorder?
Sato, K. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110484 · Cited by 8 · see citing works
Subanesthetic ketamine with an AMPAkine attenuates motor impulsivity in rats
Davis-Reyes, B. D., Smith, A. E., Xu, J., Cunningham, K. A., Zhou, J., & Anastasio, N. C. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000623 · Cited by 6 · see citing works
Rubin, B. R., Johnson, M. A., Berman, J. M., Goldstein, E., Pertsovskaya, V., Zhou, Y., Contoreggi, N. H., Dyer, A. G., Gray, J. D., Waters, E. M., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100236 · Cited by 5 · see citing works
Moidunny, S., Benneyworth, M. A., Titus, D. J., Beurel, E., Kolli, U., Meints, J. P., Jalodia, R., Ramakrishnan, S., Atkins, C. M., & Roy, S. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15288 · Cited by 4 · see citing works
Self-citationJavaheri, E. D., Wie, C. S., Covington, S. M., Misra, L., Pew, S., Viswanath, O., Freeman, J., & Maloney, J. A. (2025) · Current Pain and Headache Reports · doi:10.1007/s11916-025-01408-w · Cited by 4 · see citing works
Guo, L. M., Wang, S., Tian, H., Shang, M., Xu, J., & Wang, C. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad299 · Cited by 3 · see citing works
de Miranda, A. S., Toscano, E. C. D. B., Venna, V. R., Graeff, F. G., & Teixeira, A. L. (2025) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2025.2460674 · Cited by 2 · see citing works
Rozov, S. V., Rosenholm, M., Hintikka, S., & Rantamäki, T. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136200 · Cited by 1 · see citing works
da Costa, M. D. A., Pedro, L. C., Ebs, M. F. P., Menegaz, H. M., Bolan, S. J., Machado, A. D., dos Santos, J. C. C., Réus, G. Z., & Gonçalves, C. L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05565-2 · Cited by 1 · see citing works
Biological theories of suicidal behaviour
Turecki, G. (2021) · doi:10.1093/med/9780198834441.003.0022 · Cited by 1 · see citing works
Kang, M. J. Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821033-8.00002-2
Perspective Chapter: Ketamine, Depression, and Gender Bias
Alshammari, T. K., Alseraye, S., Al-Rasheed, N. M., Dayel, A. F. B., Alonazi, A. S., Sabhan, J. F. A., & Alshammari, M. A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103656
Recent advances in rapid-acting antidepressants
Pan, L., He, Y., Wang, G., & Shen, J. (2025) · Scientia Sinica Chimica · doi:10.1360/ssc-2025-0157
Lullau, A. P. M., & Haga, E. M. W. (2025) · Neuromethods · doi:10.1007/978-1-0716-4603-8_3
Ketamine’s Multifaceted Neuropharmacological and Neurobiological Actions
Kohtala, S., & Annala, I. (2025) · Neuromethods · doi:10.1007/978-1-0716-4603-8_2
González-Hernández, G., Rozov, S. V., Berrocoso, E., & Rantamäki, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.07.716906
The Complex Role of Serotonin–Dopamine–Glutamate Receptors in Major Depression
Orsolini, L., Longo, G., Giordano, M., & Volpe, U. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_15
Al‐kuraishy, H. M., Abass, S. A., Mahana, H. A. M., Elbanna, O. A., Shahin, I., Radwan, A. A., MohamedMohamed, O. E.-S., Baktoot, A. M. L., & Batiha, G. E. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12110-4
González-Hernández, G., Rozov, S. V., Berrocoso, E., & Rantamäki, T. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111221
- Authors
- Beurel, E., Grieco, S. F., Amadei, C., Downey, K., & Jope, R. S.
- Affiliations
- University of Miami (US)
- Corresponding author
- Beurel, Eléonore
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2016-09
- Volume
- 18
- Issue
- 6
- Pages
- 473-480
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- PMC
- PMC5071181
- OpenAlex
- W2526511830
- Cited by
- 76
- References
- 45
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 14 · 2019: 5 · 2018: 10 · 2017: 8 · 2016: 1 · 2015: 1
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH038752, MH090236, MH095380, MH104656)
- Brain and Behavior Research Foundation
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- ketamine, glycogen synthase kinase-3, AMPA receptors, GluA1 subunit, AMPA receptor trafficking, receptor internalization, antidepressant mechanism, NMDA receptor antagonists, hippocampus, rapid-acting antidepressants
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Antidepressive Agents, Bipolar Disorder, Disease Models, Animal, Hippocampus, Ketamine, Membrane Proteins, Phosphorylation, Signal Transduction, Treatment Outcome, Receptors, AMPA, Mice, Knockout, Protein Transport, Glycogen Synthase Kinase 3, Mice, Guanylate Kinases
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