11β-hydroxysteroid dehydrogenase type 1 is expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes: The expression and role of HSD11β1 in SZ95 sebocytes
Open accessAbstract
BACKGROUND: Glucocorticoids (GCs) affect the pathophysiology of sebaceous glands, causing development or exacerbation of acne. The availability of GCs is regulated by isoenzymes of 11β-hydroxysteroid dehydrogenase (11βHSD) at tissue-specific levels. 11βHSD type 1 (HSD11β1) is a reductase, catalysing the conversion of cortisone to active cortisol, and is highly expressed in liver and adipose tissue. Recently, HSD11β1 was observed in human skin in keratinocytes and fibroblasts. OBJECTIVES: To investigate the expression of HSD11β1 in sebaceous glands of normal and acne-involved skin, and to examine the role of HSD11β1 in GC-induced lipid synthesis and toll-like receptor 2 (TLR2) expression in sebocytes. METHODS: Expression of HSD11β1 was examined by immunohistochemistry in acne lesional skin and normal skin of healthy volunteers. The cultured SZ95 sebocytes were treated with dexamethasone, and the lipid synthesis and mRNA levels of sterol regulatory element binding protein 1 (SREBP-1) and TLR2 were determined. Use of an HSD11β1 inhibitor and the small interference RNA (siRNA) approach were used to investigate the role of HSD11β1 on the GC regulation of sebocyte functions. RESULTS: HSD11β1 was expressed in human sebaceous glands and upregulated in acne lesional skin. HSD11β1 mRNA was enhanced by dexamethasone and cytokines in SZ95 sebocytes. Dexamethasone enhanced lipid synthesis, partially through the transcriptional induction of SREBP-1, and also by increasing TLR2 mRNA levels. Inhibition of HSD11β1 by PF-915275 or siRNA significantly inhibited the GC-induced lipid synthesis and the mRNA expression of SREBP-1 and TLR2. CONCLUSIONS: Our results indicate that HSD11β1 plays a key role in the modulation of GC action on sebocytes, including sebum production and TLR2-mediated inflammation, thereby influencing the pathogenesis of acne.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intracellular conversion by 11βHSD1 and 11βHSD2 together with GR activity is a key mechanism of tissue-specific regulation of glucocorticoid action contributing to glucocorticoid deficiency.
“Recent studies have demonstrated that intracellular conversion, performed by these two enzymes, together with GR activity, represent a key mechanism of tissue-specific regulation of GC action contributing to GC deficiency, which constitutes a big challenge in dermatology [64, 66, 81, 148, 149].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tiganescu, A., Walker, E. A., Hardy, R. S., Mayes, A. E., & Stewart, P. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.257 · Cited by 122 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Self-citationSebum lipids influence macrophage polarization and activation
Lovászi, M., Mattii, M., Eyerich, K., Gácsi, A., Csányi, E., Kovács, D., Rühl, R., Szegedi, A., Kemény, L., Ståhle, M., et al. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15754 · Cited by 88 · see citing works
Self-citation
- Authors
- Lee, S. E., Kim, J.-M., Jeong, M.-K., Zouboulis, C. C., & Lee, S. H.
- Affiliations
- CHA University Bundang Medical Center (KR)
- Yonsei University (KR)
- Städtisches Klinikum Dessau (DE)
- Corresponding author
- Lee, S.E.
- ORCID
- Lee, S.E.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-21
- Volume
- 168
- Issue
- 1
- Pages
- 47-55
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W1622155922
- Cited by
- 32
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- 11β-hydroxysteroid dehydrogenase type 1, sebaceous glands, sebocytes, acne, glucocorticoids, dexamethasone, SREBP1, TLR2, inflammation
- MeSH terms
- Acne Vulgaris, Aminopyridines, Cells, Cultured, Dexamethasone, Enzyme Inhibitors, Glucocorticoids, Humans, Indoles, Lipids, Sebaceous Glands, Sulfonamides, RNA, Small Interfering, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Toll-Like Receptor 2, Sterol Regulatory Element Binding Protein 1, Dual Specificity Phosphatase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
