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Cited by 39Lymphatic System and DiseasesLymphatic Disorders and TreatmentsParasitic Diseases Research and Treatment

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Phenotypic modulation of smooth muscle cells in lymphoedema

Ogata, F., Fujiu, K., Koshima, I., Nagai, R., Manabe, I.·2015·British Journal of Dermatology
DOI 10.1111/bjd.13482
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Abstract

Background Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis. Objectives We analysed SMCs in lymphatic vessels from the lymphoedematous legs of 29 patients. Methods Expression of smooth muscle α-actin (SMαA) and smooth muscle myosin heavy chain (SM-MHC) isoforms SM1 and SM2 was investigated using immunohistochemistry. Results Compared with normal lymphatic vessels, all affected lymphatic vessels in chronic lymphoedema showed marked wall thickening. In addition to increases in the numbers of rows of SMαA(+) SM1(+) SMCs in the tunica media, SMCs were also observed in the subendothelial region (tunica intima). While most intimal and medial cells were positive for SMαA and SM1, staining for SM1 and particularly SM2, a marker of mature SMCs, progressively declined in lymphatic vessels in increasingly severe lymphoedema lesions. Consequently, the SM1(+) and SM2(+) cell fractions were significantly reduced in the tunica media and intima of lymphatic vessels. Conclusions These observations indicate that the lymphatic tunica media and tunica intima consist mainly of phenotypically modulated SMCs, and that SMCs play a key role in the developm…

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Crossref · 10.1111/bjd.13482

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  • Significant collecting LV remodeling occurs depending on the stage of lymphedema, with vessel morphology changes occurring as lymphedema progresses.

    “and recent histological characterizations have uncovered significant collecting LV remodeling, depending on the stage of lymphedema, with vessel morphology changes occurring as lymphedema progresses (144).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [144]

  • LMCs dedifferentiate and proliferate, with some collecting LVs undergoing inward remodeling, which further increases resistance to flow and reduces lymph transport.

    “Eventually, LMCs dedifferentiate and proliferate, with some collecting LVs undergoing inward remodeling (144), which further increases resistance to flow and reduces lymph transport.”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [144]

Citations

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Metadata

Authors
Ogata, F., Fujiu, K., Koshima, I., Nagai, R., & Manabe, I.
Affiliations
  • The University of Tokyo (JP)
  • Jichi Medical University (JP)
Corresponding author
Manabe, I.
ORCID
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
2015-03-09
Volume
172
Issue
5
Pages
1286-1293
ISSN
0007-0963 (ISSN-L)
DOI
10.1111/bjd.13482
OpenAlex
W2062331608
Cited by
39
References
2
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 1
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 176 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science, and Technology
  • Council for Science and Technology Policy
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
lymphedema, smooth muscle cells, lymphatic vessels, smooth muscle actin, smooth muscle myosin heavy chain, tunica media, tunica intima, lymphatic dysfunction
MeSH terms
Actins, Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Fibrosis, Humans, Immunohistochemistry, Lymphedema, Male, Middle Aged, Phenotype, Myosin Heavy Chains, Smooth Muscle Myosins, Myocytes, Smooth Muscle, Lymphatic Vessels, Microscopy, Electron, Transmission

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