Cell proliferation in human coronary arteries.
Open accessAbstract
Despite the lack of direct evidence for cell multiplication, proliferation of smooth muscle cells in human atherosclerotic lesions has been assumed to play a central role in ontogeny of the plaque. We used antibodies to cell cycle-related proteins on tissue sections of human arteries and coronary atherosclerotic plaques. Specific cell types were identified by immunochemical reagents for smooth muscle, monocyte-macrophages, and other blood cells. Low rates of smooth muscle cell proliferation were observed. Macrophages were also observed with rates of proliferation comparable to that of the smooth muscle. Additional replicating cells could not be defined as belonging to specific cell types with the reagents used in this study. These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
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Macrophage proliferation in advanced human coronary lesions appears very low, below 1%.
“Interestingly, however, the magnitude of macrophage proliferation in advanced coronary lesions in humans seems to be very low (<1%)164.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [164]
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
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- Authors
- Gordon, D., Reidy, M. A., Benditt, E. P., & Schwartz, S. M.
- Affiliations
- University of Washington (US)
- ORCID
- Schwartz, S M
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 12
- Pages
- 4600-4604
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC54164
- OpenAlex
- W1997447547
- Cited by
- 532
- References
- 41
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 7
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Wood Johnson Foundation
- American Heart Association
- National Institutes of Health (5r01hl042119-09)
- National Heart, Lung, and Blood Institute (HL42119, HL03174)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- cell proliferation, coronary arteries, atherosclerosis, vascular smooth muscle cells, macrophages, cell cycle proteins, atherosclerotic plaque, leukocyte proliferation, human atherosclerotic plaque
- MeSH terms
- Animals, Arteriosclerosis, Autoradiography, Cell Division, Coronary Disease, Coronary Vessels, DNA, Humans, Immunohistochemistry, Mitosis, Muscle, Smooth, Vascular, Cardiomyopathies, Nuclear Proteins, Rats, Inbred Strains, Thymidine, Tritium, Proliferating Cell Nuclear Antigen, Rats
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