Cited by 532Atherosclerosis and Cardiovascular DiseasesCoronary Interventions and DiagnosticsCerebrovascular and Carotid Artery Diseases

Cell proliferation in human coronary arteries.

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Gordon, D, Reidy, M A, Benditt, E P, Schwartz, S M·1990·Proceedings of the National Academy of Sciences

Abstract

Despite the lack of direct evidence for cell multiplication, proliferation of smooth muscle cells in human atherosclerotic lesions has been assumed to play a central role in ontogeny of the plaque. We used antibodies to cell cycle-related proteins on tissue sections of human arteries and coronary atherosclerotic plaques. Specific cell types were identified by immunochemical reagents for smooth muscle, monocyte-macrophages, and other blood cells. Low rates of smooth muscle cell proliferation were observed. Macrophages were also observed with rates of proliferation comparable to that of the smooth muscle. Additional replicating cells could not be defined as belonging to specific cell types with the reagents used in this study. These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.

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Crossref · 10.1073/pnas.87.12.4600

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Authors
Gordon, D., Reidy, M. A., Benditt, E. P., & Schwartz, S. M.
Affiliations
University of Washington (US)
Venue
Proceedings of the National Academy of Sciences
Published
1990-06
Volume
87
Issue
12
Pages
4600-4604
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1997447547
Cited by
532
References
41
Citations by year
2026: 7 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 7
FWCI
9.63
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Robert Wood Johnson Foundation
  • American Heart Association
  • National Institutes of Health (5r01hl042119-09)
  • National Heart, Lung, and Blood Institute (HL42119, HL03174)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords
cell proliferation, coronary arteries, atherosclerosis, vascular smooth muscle cells, macrophages, cell cycle proteins, atherosclerotic plaque, leukocyte proliferation, human atherosclerotic plaque
MeSH terms
Animals, Arteriosclerosis, Autoradiography, Cell Division, Coronary Disease, Coronary Vessels, DNA, Humans, Immunohistochemistry, Mitosis, Muscle, Smooth, Vascular, Cardiomyopathies, Nuclear Proteins, Rats, Inbred Strains, Thymidine, Tritium, Proliferating Cell Nuclear Antigen, Rats

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