The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Atopic dermatitis: the skin barrier and beyond
Abstract
BACKGROUND: Atopic dermatitis is the most common chronic inflammatory skin disorder, affecting up to 20% of children and 10% of adults in industrialized countries. This highly debilitating condition poses a considerable burden to both the individual and society at large. The pathophysiology of atopic dermatitis is complex, encompassing both genetic and environmental risk factors. METHODS: This is a narrative review based on a systematic literature search. CONCLUSIONS: Dysregulation of innate and adaptive immunity plays a key role; however, recent epidemiological, genetic and molecular research has focused interest on skin barrier dysfunction as a common precursor and pathological feature. Current understanding of the aetiology of atopic dermatitis highlights disruption of the epidermal barrier leading to increased permeability of the epidermis, pathological inflammation in the skin, and percutaneous sensitization to allergens. Thus, most novel treatment strategies seek to target specific aspects of the skin barrier or cutaneous inflammation. Several studies have also shown promise in preventing atopic dermatitis, such as the early use of emollients in high-risk infants. This may have broader implications in terms of halting the progression to atopic comorbidities including food allergy, hay fever and asthma.
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Citations
Cites
Diagnostic features of atopic dermatitis
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Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Randomized trial of peanut consumption in infants at risk for peanut allergy
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110
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Self-citationKong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., Program, N. C. S., et al. (2012) · Genome Research · doi:10.1101/gr.131029.111 · Cited by 1,808
The cornified envelope: a model of cell death in the skin
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Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
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Filaggrin Mutations Associated with Skin and Allergic Diseases
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Cited by
Torres, T., Ferreira, E. O., Gonçalo, M., Mendes-Bastos, P., Selores, M., & Filipe, P. (2019) · Acta Médica Portuguesa · doi:10.20344/amp.11963 · Cited by 298
Update on the Pathogenesis and Therapy of Atopic Dermatitis
Li, H., Zhang, Z., Zhang, H., Guo, Y., & Yao, Z. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08880-3 · Cited by 277
Brough, H. A., Nadeau, K. C., Sindher, S. B., Alkotob, S. S., Chan, S., Bahnson, H. T., Leung, D. Y. M., & Lack, G. (2020) · Allergy · doi:10.1111/all.14304 · Cited by 275
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202
Cutaneous barrier dysfunction in allergic diseases
Leung, D. Y. M., Berdyshev, E., & Goleva, E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.021 · Cited by 190
Metadata
- Authors
- Tsakok, T., Woolf, R., Smith, C. H., Weidinger, S., & Flohr, C.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-10-10
- Volume
- 180
- Issue
- 3
- Pages
- 464-474
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2809796857
- Cited by
- 287
- References
- 130
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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