Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 208

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

Open access
Jäger, Richard, Bertrand, Mathieu J.M., Gorman, Adrienne M., Vandenabeele, Peter, Samali, Afshin·2012·Biology of the Cell
DOI 10.1111/boc.201100055
Open this paper in CoChat — free account

Abstract

One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In spite of this, our knowledge of the molecular mechanisms that regulate cell fate following ER stress is limited. The UPR is initiated by three ER transmembrane receptors: PKR‐like ER kinase (PERK), activating transcription factor (ATF) 6 and inositol‐requiring enzyme 1 (IRE1). These proteins sense the accumulation of unfolded proteins and their activation triggers specific adaptive responses to resolve the stress. Intriguingly, the very same receptors can initiate signalling pathways that lead to apoptosis when the attempts to resolve the ER stress fail. In this review, we describe the known pro‐apoptotic signalling pathways emanating from activated PERK, ATF6 and IRE1 and discuss how their signalling switches from an adaptive to a pro‐apoptotic response.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/boc.201100055

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

See all 208

Metadata

Authors
Jäger, R., Bertrand, M. J. M., Gorman, A. M., Vandenabeele, P., & Samali, A.
Venue
Biology of the Cell
Publisher
Wiley
Published
2012-02-29
Volume
104
Issue
5
Pages
259-270
ISSN
  • 0248-4900 (ISSN-L)
  • 1768-322X
DOI
10.1111/boc.201100055
OpenAlex
W2072339970
Cited by
208
References
5
FWCI
9.67
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.