The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
Open accessAbstract
Tumour cells endure both oncogenic and environmental stresses during cancer progression. Transformed cells must meet increased demands for protein and lipid production needed for rapid proliferation and must adapt to exist in an oxygen‐ and nutrient‐deprived environment. To overcome such challenges, cancer cells exploit intrinsic adaptive mechanisms such as the unfolded protein response (UPR). The UPR is a pro‐survival mechanism triggered by accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), a condition referred to as ER stress. IRE1, PERK and ATF6 are three ER anchored transmembrane receptors. Upon induction of ER stress, they signal in a coordinated fashion to re‐establish ER homoeostasis, thus aiding cell survival. Over the past decade, evidence has emerged supporting a role for the UPR in the establishment and progression of several cancers, including breast cancer, prostate cancer and glioblastoma multiforme. This review discusses our current knowledge of the UPR during oncogenesis, tumour growth, metastasis and chemoresistance.
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Cited by
Reich, S., Nguyen, C. D. L., Has, C., Steltgens, S., Soni, H., Coman, C., Freyberg, M., Bichler, A., Seifert, N., Conrad, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16747-y · Cited by 90
Type I interferons and endoplasmic reticulum stress in health and disease
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Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer
Quagliano, A., Gopalakrishnapillai, A., & Barwe, S. P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00992 · Cited by 56
Synergism in actions of HBV with aflatoxin in cancer development
Jin, J., Kouznetsova, V. L., Kesari, S., & Tsigelny, I. F. (2023) · Toxicology · doi:10.1016/j.tox.2023.153652 · Cited by 43
Zhang, X., Wang, J., Lu, J., Su, L., Wang, C., Huang, Y., Zhang, X., & Zhu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.689626 · Cited by 24
Metadata
- Authors
- Madden, E., Logue, S. E., Healy, S. J., Manie, S., & Samali, A.
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2018-10-29
- Volume
- 111
- Issue
- 1
- Pages
- 1-17
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- OpenAlex
- W2897704361
- Cited by
- 359
- References
- 117
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Madden, E., Logue, S. E., Healy, S. J., Manie, S., & Samali, A. (2019). The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance. Biology of the Cell. https://doi.org/10.1111/boc.201800050
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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