Vascular-specific growth factors and blood vessel formation

Tumor angiogenesis: therapeutic implications

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Mechanisms of angiogenesis

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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Mechanisms of angiogenesis and arteriogenesis

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

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Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

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Transplacental Carcinogenesis by Stilbestrol

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

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Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

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Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

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Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

Wang, H. U., Chen, Z., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,678 · see citing works

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

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Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

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Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

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Angiopoietin-1 protects the adult vasculature against plasma leakage

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A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

Benjamin, L. E., Hemo, I., & Keshet, E. (1998) · Development · doi:10.1242/dev.125.9.1591 · Cited by 1,265 · see citing works

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

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Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., & Shibuya, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9349 · Cited by 1,063 · see citing works

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisPreprint

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Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

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Clinical applications of angiogenic growth factors and their inhibitors

Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004 · see citing works

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

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VEGF is required for growth and survival in neonatal mice

Gerber, H., Hillan, K. J., Ryan, A. M., Kowalski, J., Keller, G.-A., Rangell, L. K., Wright, B. D., Radtke, F., Aguet, M., & Ferrara, N. (1999) · Development · doi:10.1242/dev.126.6.1149 · Cited by 913 · see citing works

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D. (1998) · Science · doi:10.1126/science.282.5388.468 · Cited by 818 · see citing works

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular developmentPreprint

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Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., & Dvorak, A. M. (1999) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-59953-8_6 · Cited by 743 · see citing works

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF

Holash, J. A., Wiegand, S. J., & Yancopoulos, G. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203035 · Cited by 738 · see citing works

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

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Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

Gerety, S. S., Wang, H. U., Chen, Z., & Anderson, D. J. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80342-1 · Cited by 707 · see citing works

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

Carmeliet, P., Ng, Y., Nuyens, D., Theilmeier, G., Brusselmans, K., Cornelissen, I., Ehler, E., Kakkar, V. V., Stalmans, I., Mattot, V., et al. (1999) · Nature Medicine · doi:10.1038/8379 · Cited by 679 · see citing works

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

Ferrara, N., Chen, H., Davis-Smyth, T., Gerber, H. P., Nguyen, T.-N., Peers, D. H., Chisholm, V., Hillan, K. J., & SCHWALL, R. H. (1998) · Nature Medicine · doi:10.1038/nm0398-336 · Cited by 624 · see citing works

Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

Detmar, M. J., Brown, L. F., Schön, M. P., Elicker, B. M., Velasco, P., Richard, L., Fukumura, D., Monsky, W. L., Claffey, K. P., & Jain, R. K. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00262.x · Cited by 550 · see citing works

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

Ferrara, N. (1999) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59953-8_1 · Cited by 533 · see citing works

Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity

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Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

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Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

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Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

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Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression

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Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin

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Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

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A model of angiogenesis in the mouse cornea.

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VEGF Gene Delivery to Muscle

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Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact

Hirschi, K. K., Rohovsky, S. A., Beck, L. H., et al. (1999) · Circulation Research · doi:10.1161/01.res.84.3.298 · Cited by 340 · see citing works

Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

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Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

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Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity.

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Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development

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In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

Zagzag, D., Hooper, A. T., Friedlander, D. R., Chan, W., Holash, J. A., Wiegand, S. J., Yancopoulos, G. D., & Grumet, M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7162 · Cited by 220 · see citing works

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

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Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF)

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The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis

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The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

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Current biology of VEGF-B and VEGF-C

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Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors

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Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

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Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

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Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme

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Vascular Endothelial Growth Factor Receptor-3

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Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trial

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Results of Intracoronary Recombinant Human Vascular Endothelial Growth Factor (rhVEGF) Administration Trial

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The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591 · see citing works

Tumorigenesis and the angiogenic switch

Bergers, G., & Benjamin, L. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1093 · Cited by 3,559 · see citing works

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

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VEGF-Trap: A VEGF blocker with potent antitumor effects

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Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration

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Mechanisms of normal and tumor-derived angiogenesis

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Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain

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Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival <i>in vivo</i>

Lobov, I. B., Brooks, P. C., & Lang, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172161899 · Cited by 676 · see citing works

Drug resistance and new therapies in colorectal cancer

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Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies

Zimna, A., & Kurpisz, M. (2015) · BioMed Research International · doi:10.1155/2015/549412 · Cited by 604 · see citing works

Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

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Glioblastoma: defining tumor niches

Hambardzumyan, D., & Bergers, G. (2015) · Trends in Cancer · doi:10.1016/j.trecan.2015.10.009 · Cited by 522 · see citing works

Fluid forces control endothelial sprouting

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Creating perfused functional vascular channels using 3D bio-printing technology

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Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

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Susquehanna Chorale Spring Concert "Roots and Wings"

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