Therapeutic potential of nadph oxidase 1/4 inhibitors

Teixeira, G, Szyndralewiez, C, Molango, S, Carnesecchi, S, Heitz, F, Wiesel, P, Wood, J M·2017·British Journal of Pharmacology
DOI 10.1111/bph.13532

Cited by (166)

Items 101–166 of 166

  1. Beyond M1/M2: The role of reactive oxygen species in liver fibrosis and immune modulation
    Lu, Huilun, Huang, Jie, Wang, Ya-chao, Casals, Eudald, Casals, Gregori, Zeng, Muling · 2025 · Redox Biology
  2. Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts
    Hui‐Ching Tseng, Chih‐Chung Lin, Chen-Yu Wang, Chien-Chung Yang, Li‐Der Hsiao, Chuen‐Mao Yang · 2018 · Cellular and Molecular Life Sciences
  3. Acute glucose fluctuation promotes in vitro intestinal epithelial cell apoptosis and inflammation via the NOX4/ROS/JAK/STAT3 signaling pathway
    Bingyu Chen, Yuanyuan Jia, Dongxue Lu, Zhiguang Sun · 2021 · Experimental and Therapeutic Medicine
  4. A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production
    Namrata Tomar, Shima Sadri, Allen W. Cowley, Chun Yang, Nabeel Quryshi, Venkat Reddy Pannala, Said H. Audi, Ranjan K. Dash · 2019 · Free Radical Biology and Medicine
  5. GKT136901 protects primary human brain microvascular endothelial cells against methamphetamine-induced blood-brain barrier dysfunction
    Jong Su Hwang, Eun-Hye Cha, Eunyoung Ha, Byoungduck Park, Ji Hae Seo · 2020 · Life Sciences
  6. NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects
    Dina S. Vara, Anuradha Tarafdar, Meral Celikag, Daniela Patinha, Christina E. Gulácsy, Ellie Hounslea, Zach Warren, Barbara Ferreira, Maarten P. Koeners, Lorenzo Caggiano et al. · 2020 · The FASEB Journal
  7. Effect of NADPH oxidase inhibitors in an experimental retinal model of excitotoxicity
    Stavroula Dionysopoulou, Per Wikström, Erik Walum, Kyriaki Thermos · 2020 · Experimental Eye Research
  8. A Bioluminescent 3CLPro Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors
    Cyrille Mathieu, Franck Touret, Clémence Jacquemin, Yves Louis Janin, Antoine Nougaırède, Manon Brailly, Magalie Mazelier, Didier Décimo, Virginie Vasseur, Aymeric Hans et al. · 2021 · Viruses
  9. Pharmacology of oxidative stress: translational opportunities
    Andreas Daiber, Fabio Di Lisa, Péter Ferdinandy · 2017 · British Journal of Pharmacology
  10. The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling
    Pauline Labbé, Éric Thorin, Nathalie Thorin‐Trescases · 2025 · Antioxidants
  11. When nitrosative stress hits the endoplasmic reticulum: Possible implications in oxLDL/oxysterols-induced endothelial dysfunction
    Maria Gemma Nasoni, Rita Crinelli, Luigi Iuliano, Francesca Luchetti · 2023 · Free Radical Biology and Medicine
  12. Oxidative/nitrative stress in the pathogenesis of systemic sclerosis: are antioxidants beneficial?
    Paul R. J. Ames, Tommaso Bucci, Mira Merashli, Marta Amaral, Alessia Arcaro, Fabrizio Gentile, Jaffar Nourooz‐Zadeh, José Delgado Alves · 2018 · Free Radical Research
  13. Oxidative Stress and Its Relation to Lower Urinary Tract Symptoms
    Karl‐Erik Andersson · 2022 · International Neurourology Journal
  14. New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation
    Mona O. Sarhan, Hesham Haffez, Nosaiba A. Elsayed, Radwan S. El-Haggar, Wafaa Abdou Zaghary · 2023 · Bioorganic Chemistry
  15. Hochkonversion von Reduktionsmitteln
    Mikhail A. Syroeshkin, Febin Kuriakose, Evgeniya A. Saverina, Vladislava A. Timofeeva, Mikhail Petrovich Egorov, Igor V. Alabugin · 2018 · Angewandte Chemie
  16. Dual inhibition of oxidative phosphorylation and glycolysis using a hyaluronic acid nanoparticle NOX inhibitor enhanced response to radiotherapy in colorectal cancer
    Lumeng Zhang, Tongrui Liu, Minglong Chen, Shi Gao, Charles A. Staley, Lily P H Yang, Lei Zhu · 2025 · Biomaterials
  17. Calorie restriction mimetics against aging and inflammation
    Sakshi Chaudhary, Mani Raj Chaudhary, Manoj Kumar Jena, Prasana Kumar Rath, Bidyut Prava Mishra, Biswaranjan Paital, Ashish Vyas, Dipak Kumar Sahoo, Prabhakar Singh, Mohammad Murtaza Mehdi · 2025 · Biogerontology
  18. Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease
    Vittoria Cammisotto, Emanuele Valeriani, Pasquale Pignatelli, Francesco Violi · 2025 · Antioxidants
  19. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation
    Eun Bee Oh, Hye Ji Shin, Hyunseong Yu, Joara Jang, Ji Won Park, Tong‐Shin Chang · 2024 · Life Sciences
  20. Nox4 is involved in acute kidney injury associated to intravascular hemolysis
    Cristina García‐Caballero, Melania Guerrero‐Hue, Mercedes Vallejo‐Mudarra, Alejandra Palomino Antolín, Celine Decouty‐Pérez, Luz Marina Sánchez‐Mendoza, José M. Villalba, José Antonio González-Reyes, Lucas Opazo-Ríos, Cristina Vázquez‐Carballo et al. · 2024 · Free Radical Biology and Medicine
  21. NADPH‐oxidase‐derived ROS alters cell migration by modulating adhesions dynamics
    Maurício Tavares Tamborindeguy, Bibiana Franzen Matte, Grasieli de Oliveira Ramos, Alessandro Menna Alves, Lisiane Bernardi, Marcelo Lazzaron Lamers · 2018 · Biology of the Cell
  22. Redox-Redux and NADPH Oxidase (NOX): Even More Complicated than We Thought it Might Be
    Frank Louis Meyskens, Feng Liu · 2017 · Journal of Investigative Dermatology
  23. Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage
    María Castejón-Griñán, Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Cecilia Herráiz, Celia Jiménez‐Cervantes, José Carlos García-Borrón · 2024 · Redox Biology
  24. Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner
    Kirsten Ludwig, Janel E. Le Belle, Sree Deepthi Muthukrishnan, Jantzen Sperry, Michael C. Condro, Erina Vlashi, Frank Pajonk, Harley I. Kornblum · 2023 · Antioxidants and Redox Signaling
  25. Blockade of mTORC1‐NOX signaling pathway inhibits TGF‐β1‐mediated senescence‐like structural alterations of the retinal pigment epithelium
    Seok Jae Lee, Soo‐Jin Kim, Dong Hyun Jo, Kyu‐Sang Park, Jeong Hun Kim · 2021 · The FASEB Journal
  26. Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells
    Muhammed Burak Demircan, Peter C. Mgbecheta, Anne Kresinsky, Tina M. Schnoeder, Katrin Schröder, Florian Heinrich Heidel, Frank‐D. Böhmer · 2022 · Antioxidants
  27. FEATURES OF REDOX REGULATION IN TUMOR CELLS
    N. K. Zenkov, P. M. Kozhin, A. V. Vcherashnyaya, Г. Г. Мартинович, N. V. Kandalintseva, E. B. Menshchikova · 2019 · Сибирский научный медицинский журнал
  28. Thymus serpyllum L. Essential Oil: Phytochemistry and in Vitro and in Silico Screening of Its Antimicrobial, Antioxidant and Anti-Inflammatory Properties
    Samiah Hamad Al-Mijalli, Fahad M. Alshabrmi, Sulaiman Mohammed Alnasser, Naoufal El Hachlafi, Hanae Naceiri Mrabti, Mohamed Addi, Amine Elbouzidi, Naglaa S. Ashmawy, Amine Batbat, Emad M. Abdallah et al. · 2025 · Phyton
  29. Phytochemical investigation, antibacterial, and ameliorative potential effects of Tamarix nilotica on LPS-induced acute lung injury model in mice
    Rasha Assiri, Thanaa Ahmed El-Masry, Sahar M. El-Haggar, Engy Elekhnawy, Salwa Seif Eldin, Aya Hassan El-Kadem, Sally Abdallah Mostafa, Aya Ibrahim Elberri, Sameh Magdeldin, Walaa A. Negm et al. · 2023 · Biomedicine & Pharmacotherapy
  30. Extracellular Redox Balance as a Determinant of Immune Regulation and Tissue Inflammation
    Rebecca Seitz, Martina A. Müller, Karsten Gülow · 2026 · Antioxidants
  31. Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Mi Zhou, Hou-Li Zhang, Liang Gong, Jianlin Hu, Hu Luo, Xiangdong Zhou · 2023 · BMC Medical Genomics
  32. Atherosclerosis: From the Disruption of Mitochondrial Membrane Potential to the Potential Interventional Strategies
    Dexiang Xia, Yanmei Chen, Guifang Luo, Dangheng Wei · 2022 · Current Medicinal Chemistry
  33. Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review
    Gaurav Kumar, Manisha Saini, Suman Kundu · 2021 · Canadian Journal of Physiology and Pharmacology
  34. Decoding STAT3: a new frontier in understanding and treating hyperoxic lung injury
    Wulan Li, Qian Liu, Wenyan Xiong, Xu Zhong, Lei Tian · 2025 · Frontiers in Immunology
  35. Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy
    Xinrong Tian, Yan Huang, Chenxin He, Ertong Dai, Zhang Xiwen, Zou Peng, Liu Ruiyan, Minlong Xia, Lu Zixuan, Jin Bilin et al. · 2026 · Phytomedicine
  36. Lipoic acid alters the microRNA signature in breast cancer cells
    Hoda Khalife, Mohammad Fayyad‐Kazan, Hussein Fayyad‐Kazan, Élie Hadchity, Nada Borghol, Nader Hussein, Bassam M. Badran · 2024 · Pathology - Research and Practice
  37. GKT137831 in combination with adipose-derived stem cells alleviates high glucose–induced inflammaging and improves diabetic wound healing
    Yunxian Dong, Youliang Zhang, Fang‐Wei Li, Bing Tang, Dongming Lv, Hai‐Bin Wang, Sheng‐Kang Luo · 2023 · Journal of Leukocyte Biology
  38. Diapocynin treatment induces functional and structural improvements in an advanced disease state in the mdx5Cv mice
    Ghali Guedira, Olivier Petermann, Léonardo Scapozza, Hesham M. Ismail · 2024 · Biomedicine & Pharmacotherapy
  39. Role of ROS and ROS generating enzymes in the human ovary
    Theresa Buck · 2018 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
  40. Nicotinamide Coenzymes and Metabolic Diseases
    Ting Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
  41. Aβ40 Improves Cerebrovascular Endothelial Function via NOX4-Dependent Hydrogen Peroxide Release
    Elizabeth Heller, Lindsey M. McGurran, Joseph K. Brown, Kathleen Love, Matthew Hobbs, Jeong Sook Kim‐Han, Byung Hee Han · 2025 · International Journal of Molecular Sciences
  42. Serum Nox1 and Gper Levels in Patients With Generalized Anxiety Disorder: A Cross‐Sectional Study in Turkiye
    Onur Hurşıtoğlu, Ergül Belge Kurutaş, Ömer Faruk Uygur, Nurinnisa Öztürk, Hilal Uygur, Fatih Sağlam, Rebecca Strawbridge · 2025 · Brain and Behavior
  43. Selective Head Cooling and NOX Inhibition Protect the Blood–Brain Barrier in Neonatal Epilepsy
    Helena Parfenova, Jianxiong Liu, Shyamali Basuroy, Rong Zhang, Mimily Harsono, Massroor Pourcyrous · 2025 · Antioxidants
  44. NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of IκBζ
    Zhuoyao Song, Coralie Pintard, Anne-Laure Pelletier, Jean‐Claude Marie, Dan Liu, Nathalie Thiéblemont, Margarita Hurtado-Nédelec, Jiao Ping, Laura Baciou, Jamel El Benna et al. · 2026 · Free Radical Biology and Medicine
  45. Mitochondrial dysfunction promotes keloid progression through metabolic reprogramming: A narrative review
    Lianbo Zhang, Mingxi Li, Guang Zhang, Zichao Wang, Haiyan Qin · 2026 · Tissue and Cell
  46. Patent Highlights December 2016–January 2017
    Hermann AM Mucke · 2017 · Pharmaceutical Patent Analyst
  47. EFFECTS OF JUICE AND SEED EXTRACT OF POMEGRANATE ON OXIDATIVE STRESS, INFLAMMATION, AND PHOSPHORYLATION OF ERK1/2 IN PARAQUAT-INDUCED ACUTE LUNG INJURY IN MICE
    Samah M. Fathy, Heba A. El‐dash, N. Salim · 2021 · Egyptian Journal Of Zoology
  48. Pirfenidone, Fluorofenidone and New Antifibrotic Drugs: Biochemistry of Direct and Indirect Effects
    MITSUAKI NISHIZAWA, Kazuhisa Nishizawa · 2018 · Annals of Biomedical Research
  49. NADPH oxidase 1 inhibition attenuates platelet activation and thrombosis in vivo without affecting haemostasis
    Dina S. Vara, Anuradha Tarafdar, Meral Celikag, Daniela Patina, Christina E. Gulácsy, Eleanor Hounslea, Zach Warren, Barbara Ferreira, Maarten P. Koeners, Lorenzo Caggiano et al. · 2020
  50. Senescence Induced by Nox4 Expressed Aberrantly in Osteoclast Precursors Accelerates Ostoeclastogenesis to Promote Osteoarthritis
    Bin Yu, Ke Shen, Hanjun Qin, Xiaonan Liu, Lei Wang, Siying He, Xingqi Zhao, Jun Yang, Shengnan Wang · 2022 · Research Square
  51. TGFβ Signaling
    Anne‐Ulrike Trendelenburg · 2020 · Royal Society of Chemistry eBooks
  52. NADPH Oxidase Nox1 do hospedeiro contribui para a manutenção do microambiente redox e crescimento do melanoma.
    Priscila Ferreira de Morais · 2020
  53. Nitric oxide and reactive oxygen species: a common mechanism of multiple comorbidities
    Mahmoud H. Elbatreek, Mohamed Saad, EmanA Elshorbagy, Aziza Eswikar · 2022 · Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science
  54. Additional file 5 of Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong · 2024 · Figshare
  55. Additional file 4 of Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong · 2024 · Figshare
  56. Additional file 1 of Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong · 2024 · Figshare
  57. Additional file 3 of Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong · 2024 · Figshare
  58. Additional file 2 of Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
    Duan Zhu, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong · 2024 · Figshare
  59. ROS and Inflammation Interplay in Hypertension and Other CVDs
    Debarshi Mondal, Mustak Ahamed, Pratyush Porel, Khadga Raj Aran · 2026 · Springer eBooks
  60. «Trained immunity» et rôle de la mémoire macrophagique dans l'immunomodulation des maladies fibro-inflammatoires
    Mohamed Maxime Jeljeli · 2020
  61. Étude de l’expression, de l’activité et du rôle de la NADPH oxydase dans la villosité choriale au premier trimestre de la grossesse : implication dans la physiopathologie de la prééclampsie
    Isabelle Hernandez · 2019
  62. Oxidative stress and signaling in renal physiology and kidney diseases
    Manoj Bhattarai, Soumya Maity, Kumar Sharma · 2026 · Elsevier eBooks
  63. NADPH Oxidase in the Mechanism of Neurodegeneration of Parkinson’s Disease
    Lauren Elizabeth Millichap, Andrey Y. Abramov · 2026 · Springer eBooks
  64. Development of a first-in-class homolog-selective, covalent NOX4 inhibitor
    Mariana Castelôa, Sara Marchese, Marta Massari, Carla Lima, Lorenzo Basile, Joana Reis, Matteo Ré, Fábio G. Martins, Sérgio F. Sousa, Inês Lima et al. · 2026 · Biomedicine & Pharmacotherapy
  65. Sex-specific responses to repeated dose of abamectin in albino rats: a focus on cytotoxicity, genotoxicity, and pro-inflammatory signaling
    Hossam El Din H. Abdelhafez, May Moustafa Amer, Nahla El Shenawy, Fatma Safina, Fatma Sh. Kalmosh, Ahmed Elshatory, Ragab A. Soliman · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
  66. Gramine limits alcohol-associated liver injury by suppressing NOX1-linked ferroptotic responses and mitochondrial dysfunction
    Yu Zhang, Luxia Su, Heran Cheng, Wei Wei, Wenxuan Xu, Xiaofeng Bao, Chunfeng Lu · 2026 · Biochemical Pharmacology