Therapeutic potential of nadph oxidase 1/4 inhibitors

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works

Non-Transgenic Mouse Models of Kidney Disease

Rabe, M., & Schaefer, F. S. (2016) · ˜The œNephron journals/Nephron journals · doi:10.1159/000445171 · Cited by 1,925 · see citing works

Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

Itzkowitz, S. H., & Yio, X. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00079.2004 · Cited by 1,272 · see citing works

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Southan, C., Sharman, J., Benson, H., Faccenda, E., Pawson, A. J., Alexander, S. P. H., Buneman, O., Davenport, A., McGrath, J., Peters, J., et al. (2015) · Nucleic Acids Res. · doi:10.1093/nar/gkv1037 · Cited by 1,121 · see citing works

Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921 · see citing works

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852 · see citing works

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847 · see citing works

Nox proteins in signal transduction

Brown, D. I., & Griendling, K. (2009) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 841 · see citing works

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786 · see citing works

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772 · see citing works

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 768 · see citing works

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

Hecker, L., Logsdon, N. J., Kurundkar, D., Kurundkar, A., Bernard, K., Hock, T., Meldrum, E., Sanders, Y. Y., & Thannickal, V. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008182 · Cited by 686 · see citing works

Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy

Lambeth, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.027 · Cited by 677 · see citing works

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

Dikalov, S., & Harrison, D. G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4886 · Cited by 639 · see citing works

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works

NADPH Oxidases in Cardiovascular Health and Disease

Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630 · see citing works

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13354 · Cited by 604 · see citing works

NADPH Oxidases: Functions and Pathologies in the Vasculature

Lassègue, B., & Griendling, K. K. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181610 · Cited by 592 · see citing works

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

Takac, I., Schröder, K., Zhang, L., Lardy, B., Anilkumar, N. P., Lambeth, J. D., Shah, A. M., Morel, F., & Brandes, R. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192138 · Cited by 524 · see citing works

Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement

Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521 · see citing works

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

Fischer, M. T., Sharma, R., Lim, J. L., Haider, L., Frischer, J. M., Drexhage, J., Mahad, D., Bradl, M., van Horssen, J., & Lassmann, H. (2012) · Brain · doi:10.1093/brain/aws012 · Cited by 507 · see citing works

Reactive oxygen generated by Nox1 triggers the angiogenic switch

Arbiser, J. L., Petros, J. A., Klafter, R., Govindajaran, B., McLaughlin, E. R., Brown, L. F., Cohen, C., Moses, M. A., Kilroy, S. M., Arnold, R. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022630199 · Cited by 489 · see citing works

Nox1 Is Involved in Angiotensin II–Mediated Hypertension: A Study in Nox1-Deficient Mice

Matsuno, K., Yamada, H., Iwata, K., Jin, D., Katsuyama, M., Matsuki, M., Takai, S., Yamanishi, K., Miyazaki, M., Matsubara, H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.573709 · Cited by 470 · see citing works

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

Takaki, A., Kawai, D., & Yamamoto, K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020704 · Cited by 452 · see citing works

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

Zhang, M., Brewer, A. C., Schröder, K., Santos, C. X. C., Grieve, D., Wang, M., Anilkumar, N. P., Yu, B., Dong, X., Walker, S. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009700107 · Cited by 447 · see citing works

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000479 · Cited by 447 · see citing works

Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury

Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 444 · see citing works

Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice

Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438 · see citing works

Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy

Byrne, J., Grieve, D., Bendall, J. K., Li, J., Gove, C. D., Lambeth, J. D., Cave, A. C., & Shah, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000099504.30207.f5 · Cited by 411 · see citing works

Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease

Volpp, B. D., Nauseef, W. M., & Clark, R. A. (1988) · Science · doi:10.1126/science.2848318 · Cited by 407 · see citing works

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., & Parkos, C. A. (1987) · Nature · doi:10.1038/327717a0 · Cited by 407 · see citing works

Critical role of nox4-based nadph oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy

Sedeek, M., Callera, G., Montezano, A., Gutsol, A., Heitz, F., Szyndralewiez, C., Page, P., Kennedy, C. R. J., Burns, K. D., Touyz, R. M., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00028.2010 · Cited by 396 · see citing works

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386 · see citing works

Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production From a Nox1-Based NADPH Oxidase

Sorescu, G. P., Song, H. W., Tressel, S. L., Hwang, J., Dikalov, S., Smith, D. A., Boyd, N. L., Platt, M. O., Lassegue, B. P., Griendling, K. K., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000145728.22878.45 · Cited by 379 · see citing works

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371 · see citing works

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070810 · Cited by 352 · see citing works

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

Rice, L. M., Padilla, C. M., McLaughlin, S. R., Mathes, A., Ziemek, J., Goummih, S., Nakerakanti, S., York, M., Farina, G., Whitfield, M. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77958 · Cited by 351 · see citing works

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

McKenzie, S. J., Baker, M. S., Buffinton, G. D., & Doe, W. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118757 · Cited by 349 · see citing works

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology · doi:10.1002/hep.25938 · Cited by 336 · see citing works

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

Amara, N., Goven, D., Prost, F., Muloway, R., Crestani, B., & Boczkowski, J. (2010) · Thorax · doi:10.1136/thx.2009.113456 · Cited by 335 · see citing works

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

Ray, R., Murdoch, C. E., Wang, M., Santos, C. X. C., Zhang, M., Alom-Ruiz, S. P., Anilkumar, N. P., Ouattara, A., Cave, A. C., Walker, S. J., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219238 · Cited by 325 · see citing works

Decreased blood pressure in NOX1‐deficient mice

Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321 · see citing works

Aiding and abetting roles of NOX oxidases in cellular transformation

Block, K. L., & Gorin, Y. C. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3339 · Cited by 301 · see citing works

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

Leoni, G., Alam, A. M., Neumann, P.-A., Lambeth, J. D., Cheng, G., McCoy, J. W., Hilgarth, R., Kundu, K., Murthy, N., Kusters, D. H. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65831 · Cited by 297 · see citing works

Oscillatory Shear Stress Stimulates Endothelial Production of O2- from p47 -dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion

Hwang, J., Saha, A., Boo, Y. C., Sorescu, G. P., McNally, J. S., Holland, S. M., Dikalov, S., Giddens, D. P., Griendling, K. K., Harrison, D. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305150200 · Cited by 296 · see citing works

A key role for nox4 in epithelial cell death during development of lung fibrosis

Carnesecchi, S., Deffert, C., Donati, Y., Basset, O., Hinz, B., Preynat-Seauve, O., Guichard, C., Arbiser, J. L., Banfi, B., Pache, J.-C., et al. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3829 · Cited by 290 · see citing works

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

Weyemi, U., Lagente-Chevallier, O., Boufraqech, M., Prenois, F., Courtin, F., Caillou, B., Talbot, M., Dardalhon, M., Al Ghuzlan, A., Bidart, J.-M., et al. (2012) · Oncogene · doi:10.1038/onc.2011.327 · Cited by 285 · see citing works

Impact of genetic background on nephropathy in diabetic mice

Gurley, S. B., Clare, S. E., Snow, K. P., Hu, A., Meyer, T. W., & Coffman, T. M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00204.2005 · Cited by 285 · see citing works

Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells

Leonard, S. E., Reddie, K. G., & Carroll, K. S. (2009) · ACS Chemical Biology · doi:10.1021/cb900105q · Cited by 282 · see citing works

New Insights on <i>NOX</i> Enzymes in the Central Nervous System

Nayernia, Z., Jaquet, V., & Krause, K.-H. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5703 · Cited by 279 · see citing works

Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo

Wingler, K., Wünsch, S., Kreutz, R. H., Rothermund, L., Paul, M., & Schmidt, H. H. H. W. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00727-4 · Cited by 269 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13355 · Cited by 267 · see citing works

NADPH oxidases in cardiovascular disease

Brandes, R. P., Weißmann, N., & Schröder, K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.030 · Cited by 266 · see citing works

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, J. X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S., & Török, N. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.007 · Cited by 251 · see citing works

Essential role for RGS9 in opiate action

Zachariou, V., Georgescu, D., Sanchez, N., Rahman, Z. U., Dileone, R., Berton, O., Neve, R. L., Sim‐Selley, L. J., Selley, D. E., Gold, S. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232594100 · Cited by 250 · see citing works

Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

Clark, R. A., Malech, H. L., Gallin, J. I., Nunoi, H., Volpp, B. D., Pearson, D. W., Nauseef, W. M., & Curnutte, J. T. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909073211005 · Cited by 245 · see citing works

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

Laleu, B., Gaggini, F., Orchard, M., Fioraso-Cartier, L., Cagnon, L., Houngninou-Molango, S., Gradia, A., Duboux, G., Merlot, C., Heitz, F., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100773e · Cited by 243 · see citing works

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling Pathways

Zhao, Q. D., Viswanadhapalli, S., Williams, P., Shi, Q., Tan, C., Yi, X., Bhandari, B., & Abboud, H. E. (2015) · Circulation · doi:10.1161/circulationaha.114.011079 · Cited by 243 · see citing works

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

Lee, M. Y., Martín, A. S., Mehta, P. K., Dikalova, A., Garrido, A. M., Datla, S. R., Lyons, E., Krause, K., Bánfi, B., Lambeth, J. D., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181925 · Cited by 234 · see citing works

Site-specific mapping and quantification of protein S-sulphenylation in cells

Yang, J. H., Gupta, V., Carroll, K. S., & Liebler, D. C. (2014) · Nature Communications · doi:10.1038/ncomms5776 · Cited by 232 · see citing works

NADPH oxidases and cancer

Roy, K., Wu, Y., Meitzler, J. L., Juhasz, A. N., Liu, H., Jiang, G., Lu, J., Antony, S., & Doroshow, J. H. (2015) · Clinical Science · doi:10.1042/cs20140542 · Cited by 231 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13347 · Cited by 230 · see citing works

Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production

Hiraga, T., Ito, S., & Nakamura, H. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3801 · Cited by 227 · see citing works

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225 · see citing works

Role of NADPH Oxidases in Liver Fibrosis

Paik, Y., Kim, J., Aoyama, T., Minicis, S. D., Bataller, R. A., & Brenner, D. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5619 · Cited by 221 · see citing works

Activation of Dual Oxidases Duox1 and Duox2

Rigutto, S., Hoste, C., Grasberger, H., Milenkovic, M., Communi, D., Dumont, J. E., Corvilain, B., Miot, F., & De Deken, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806893200 · Cited by 213 · see citing works

Novel Mechanism of Activation of NADPH Oxidase 5

Jagnandan, D., Church, J. E., Banfi, B., Stuehr, D. J., Marrero, M. B., & Fulton, D. J. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608966200 · Cited by 210 · see citing works

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

Hirano, K., Chen, W. S., Chueng, A. L. W., Dunne, A. A., Seredenina, T., Filippova, A., Ramachandran, S., Bridges, A., Chaudry, L., Pettman, G., et al. (2015) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2014.6202 · Cited by 205 · see citing works

Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells

Park, H., CHUN, J., Jung, H., CHOI, C., & Bae, Y. H. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.012 · Cited by 203 · see citing works

NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91 phox in the Regulated Production of Superoxide by Phagocytes

Geiszt, M., Lekstrom, K. J., Brenner, S., Hewitt, S. M., Dana, R., Malech, H. L., & Leto, T. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.299 · Cited by 201 · see citing works

Expression of NOX1 , a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease

Szántó, I., Rubbia‐Brandt, L., Kiss, P. J., Steger, K., Bánfi, B., Kövari, E., Herrmann, F. R., Hadengue, A., & Krause, K. (2005) · The Journal of Pathology · doi:10.1002/path.1824 · Cited by 199 · see citing works

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice

Li, J., Wang, J. J., Yu, Q., Chen, K., Mahadev, K., & Zhang, S. X. (2010) · Diabetes · doi:10.2337/db09-1057 · Cited by 199 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

Alexander, S. P. H., Catterall, W. A., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13349 · Cited by 196 · see citing works

The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice

Paik, Y., Iwaisako, K., Seki, E., Inokuchi, S., Schnabl, B., Österreicher, C. H., Kisseleva, T., & Brenner, D. A. (2011) · Hepatology · doi:10.1002/hep.24281 · Cited by 195 · see citing works

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Lan, T., Kisseleva, T., & Brenner, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129743 · Cited by 192 · see citing works

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

Coant, N., Mkaddem, S. B., Pédruzzi, E., Guichard, C., Tréton, X., Ducroc, R. A., Freund, J., Cazals-Hatem, D. L., Bouhnik, Y., Woerther, P., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01194-09 · Cited by 191 · see citing works

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

You, Y.-H., Quach, T., Saito, R., Pham, J., & Sharma, K. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030302 · Cited by 191 · see citing works

Targeting nadph oxidase with a novel dual nox1/nox4 inhibitor attenuates renal pathology in type 1 diabetes

Gorin, Y., Cavaglieri, R. C., Khazim, K., Lee, D.-Y., Bruno, F., Thakur, S., Fanti, P., Szyndralewiez, C., Barnes, J. L., Block, K., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00396.2014 · Cited by 183 · see citing works

Hepatocyte NAD(P)H Oxidases as an Endogenous Source of Reactive Oxygen Species During Hepatitis C Virus Infection

de Mochel, N. S. R., Seronello, S., Wang, S. H., Ito, C., Zheng, J. X., Liang, J. T., Lambeth, D. J., & Choi, J. (2010) · Hepatology · doi:10.1002/hep.23671 · Cited by 183 · see citing works

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

Pendyala, S., Gorshkova, I. A., Usatyuk, P. V., He, D., Pennathur, A., Lambeth, J. D., Thannickal, V. J., & Natarajan, V. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2203 · Cited by 182 · see citing works

Type IHelicobacter pyloriLipopolysaccharide Stimulates Toll-Like Receptor 4 and Activates Mitogen Oxidase 1 in Gastric Pit Cells

Kawahara, T., Teshima, S., Oka, A., Sugiyama, T., Kishi, K., & Rokutan, K. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4382-4389.2001 · Cited by 181 · see citing works

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

Sirker, A. A., Zhang, M., & Shah, A. M. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0190-z · Cited by 180 · see citing works

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

Choi, D.-H., Cristóvão, A. C., Guhathakurta, S., Lee, J., JOH, T. H., Beal, M. F., & Kim, Y.-S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3960 · Cited by 180 · see citing works

The NADPH oxidase Nox4 has anti-atherosclerotic functions

Schürmann, C., Rezende, F., Kruse, C., Yasar, Y., Löwe, O., Fork, C., van de Sluis, B., Bremer, R., Weißmann, N., Shah, A. M., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv460 · Cited by 178 · see citing works

From fatty liver to fibrosis: A tale of “second hit”

Başaranoğlu, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1158 · Cited by 177 · see citing works

Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Central d + Au Collisions at s N N = 200 GeV

Adare, A. M., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta’ani, H., Alexander, J., Andrews, K. R., Angerami, A., et al. (2015) · Physical Review Letters · doi:10.1103/physrevlett.114.192301 · Cited by 172 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

Alexander, S. P. H., Cidlowski, J. A., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13352 · Cited by 169 · see citing works

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, J. X., Sasaki, Y., Chao, T.-I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.009 · Cited by 167 · see citing works

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

Lee, C. F., Qiao, M., Schröder, K., Zhao, Q. D., & Asmis, R. (2010) · Circulation Research · doi:10.1161/circresaha.109.215392 · Cited by 167 · see citing works

The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death

Cristóvão, A. C., Choi, D.-H., Baltazar, G., Beal, M. F., & Kim, Y.-S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2459 · Cited by 165 · see citing works

Genetic disorders coupled to ROS deficiency

O’Neill, S., Brault, J., Stasia, M.-J., & Knaus, U. G. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.009 · Cited by 164 · see citing works

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

Goettsch, C., Bábelová, A., Trummer, O., Erben, R. G., Rauner, M., Rammelt, S., Weißmann, N., Weinberger, V., Benkhoff, S., Kampschulte, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67603 · Cited by 162 · see citing works

NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells

Kikuchi, H., Hikage, M., Miyashita, H., & Fukumoto, M. (2000) · Gene · doi:10.1016/s0378-1119(00)00258-4 · Cited by 161 · see citing works

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

Sedeek, M. H., Gutsol, A. A., Montezano, A. C. I., Burger, D. E., Cat, A. N. D., Kennedy, C., Burns, K. D., Cooper, M. E., Jandeleit-Dahm, K. A. M., Page, P., et al. (2012) · Clinical Science · doi:10.1042/cs20120330 · Cited by 160 · see citing works

Nadph oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice

Carnesecchi, S., Deffert, C., Pagano, A., Garrido-Urbani, S., Métrailler-Ruchonnet, I., Schäppi, M., Donati, Y., Matthay, M. A., Krause, K.-H., & Barazzone Argiroffo, C. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200902-0296oc · Cited by 160 · see citing works

Role of NADPH Oxidase and Stat3 in Statin-Mediated Protection against Diabetic Retinopathy

Al‐Shabrawey, M., Bartoli, M., El‐Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W., & Caldwell, R. B. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1754 · Cited by 160 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13353 · Cited by 159 · see citing works

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

Sancho, P., Mainez, J., Crosas-Molist, E., Roncero, C., Fernández-Rodríguez, C., Pinedo, F., Huber, H., Eferl, R., Mikulits, W., & Fabregat, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045285 · Cited by 157 · see citing works

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Ikeda, Y., Oka, S., Fong, G., Tian, R., & Sadoshima, J. (2013) · Circulation Research · doi:10.1161/circresaha.111.300171 · Cited by 157 · see citing works

Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease

Hayes, P., Dhillon, S., O’Neill, K., Thoeni, C. E., Hui, K. Y., Elkadri, A. A., Guo, C., Kovačič, L., Aviello, G., Álvarez, L., et al. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.06.005 · Cited by 156 · see citing works

Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain

Ibi, M., Matsuno, K., Shiba, D., Katsuyama, M., Iwata, K., Kakehi, T., Nakagawa, T., Sango, K., Shirai, Y., Yokoyama, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1857-08.2008 · Cited by 156 · see citing works

Increased NADPH-Oxidase Activity and Nox4 Expression During Chronic Hypertension Is Associated With Enhanced Cerebral Vasodilatation to NADPH In Vivo

Paravicini, T. M., Chrissobolis, S., Drummond, G. R., & Sobey, C. G. (2004) · Stroke · doi:10.1161/01.str.0000112974.37028.58 · Cited by 156 · see citing works

Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase

Schäppi, M. G., Jaquet, V., Belli, D. C., & Krause, K. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0119-2 · Cited by 156 · see citing works

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

Lu, W., Hu, Y., Chen, G., Chen, Z., Zhang, H., Wang, F., Feng, L., Pelicano, H., Wang, H., Keating, M. J., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001326 · Cited by 151 · see citing works

Role of Nox4 in murine models of kidney disease

Bábelová, A., Avaniadi, D., Jung, O., Fork, C., Beckmann, J., Kosowski, J., Weißmann, N., Anilkumar, N. P., Shah, A. M., Schaefer, L., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.027 · Cited by 150 · see citing works

Role for Nox1 NADPH oxidase in atherosclerosis

Sheehan, A. L., Carrell, S., Johnson, B., Stanić, B., Bánfi, B., & Miller, F. J. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.028 · Cited by 148 · see citing works

The nox4 inhibitor gkt137831 attenuates hypoxia-induced pulmonary vascular cell proliferation

Green, D. E., Murphy, T. C., Kang, B.-Y., Kleinhenz, J. M., Szyndralewiez, C., Page, P., Sutliff, R. L., & Hart, C. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0418oc · Cited by 146 · see citing works

Redox modifier genes in amyotrophic lateral sclerosis in mice

Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31265 · Cited by 145 · see citing works

NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

Khodo, S. N., Dizin, É., Sossauer, G., Szántó, I., Martin, P., Féraille, E., Krause, K. H., & de Seigneux, S. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012040373 · Cited by 144 · see citing works

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

Garrido-Urbani, S., Jemelin, S., Deffert, C., Carnesecchi, S., Basset, O., Szyndralewiez, C., Heitz, F., Page, P., Montet, X., Michalik, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014665 · Cited by 143 · see citing works

Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells

Kawahara, T., Kohjima, M., Kuwano, Y., Mino, H., Teshima-Kondo, S., Takeya, R., Tsunawaki, S., Wada, A., Sumimoto, H., & Rokutan, K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00319.2004 · Cited by 143 · see citing works

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

Wilkinson‐Berka, J. L., Rana, I., Armani, R., & Agrotis, A. (2013) · Clinical Science · doi:10.1042/cs20120212 · Cited by 140 · see citing works

Involvement of UVB-induced reactive oxygen species in TGF-β biosynthesis and activation in keratinocytes

Wang, H., & Kochevar, I. E. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.005 · Cited by 139 · see citing works

A chemical approach for detecting sulfenic acid-modified proteins in living cells

Reddie, K. G., Seo, Y. H., Muse, W. B., Leonard, S. E., & Carroll, K. S. (2008) · Molecular BioSystems · doi:10.1039/b719986d · Cited by 138 · see citing works

Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion

Matsushima, S., Tsutsui, H., & Sadoshima, J. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.03.003 · Cited by 133 · see citing works

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor β-Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

Boudreau, H. E., Emerson, S. U., Korzeniowska, A., Jendrysik, M. A., & Leto, T. L. (2009) · Journal of Virology · doi:10.1128/jvi.01059-09 · Cited by 132 · see citing works

TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

Peters, D. M., Vadász, I., Wujak, L. A., Wygrecka, M., Olschewski, A., Becker, C., Herold, S., Papp, R., Mayer, K., Rummel, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306798111 · Cited by 128 · see citing works

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

Adachi, Y., Shibai, Y., Mitsushita, J., Shang, W. H., Hirose, K., & Kamata, T. (2008) · Oncogene · doi:10.1038/onc.2008.133 · Cited by 124 · see citing works

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

Wilkinson‐Berka, J. L., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5357 · Cited by 123 · see citing works

Pivotal Role of gp91 phox -Containing NADH Oxidase in Lipopolysaccharide-Induced Tumor Necrosis Factor-α Expression and Myocardial Depression

Peng, T., Lu, X., & Feng, Q. (2005) · Circulation · doi:10.1161/01.cir.0000160366.50210.e9 · Cited by 123 · see citing works

Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4

Wendt, M. C., Daiber, A., Kleschyov, A. L., Mülsch, A., Sydow, K., Schulz, E., Chen, K., Keaney, J. F., Lassègue, B., Walter, U., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.020 · Cited by 122 · see citing works

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Őrfi, L., Szántai-Kis, C., Kéri, G., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303848 · Cited by 121 · see citing works

Ethanol and Arachidonic Acid Increase α2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1

Nieto, N., Greenwel, P., Friedman, S. L., Zhang, F., Dannenberg, A. J., & Cederbaum, A. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001422200 · Cited by 117 · see citing works

Updates of reactive oxygen species in melanoma etiology and progression

Liu, F., Dellinger, R. W., & Meyskens, F. L. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.007 · Cited by 116 · see citing works

Nox Activator 1

Niu, X.-L., Madamanchi, N. R., Vendrov, A. E., Tchivilev, I., Rojas, M., Madamanchi, C., Brandes, R. P., Krause, K. H., Humphries, J., Smith, A., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.908319 · Cited by 115 · see citing works

An Inhibitor of NADPH Oxidase-4 Attenuates Established Pulmonary Fibrosis in a Rodent Disease Model

Jarman, E. R., Khambata, V. S., Cope, C. L., Jones, P. L., Roger, J., Ye, L. Y., Duggan, N., Head, D., Pearce, A. C., Press, N. J., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0174oc · Cited by 114 · see citing works

NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury

Kallenborn-Gerhardt, W., Schröder, K., Turco, D. D., Lu, R., Kynast, K. L., Kosowski, J., Niederberger, E., Shah, A. M., Brandes, R. P., Geißlinger, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6227-11.2012 · Cited by 114 · see citing works

The human Nox4: gene, structure, physiological function and pathological significance

Guo, S., & Chen, X. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1036276 · Cited by 113 · see citing works

NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme

Hsieh, C., Shyu, W., Chiang, C.-Y., Kuo, J.-W., Shen, W., & Liu, R.-S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023945 · Cited by 111 · see citing works

Nox4 Is Critical for Hypoxia-Inducible Factor 2-α Transcriptional Activity in von Hippel-Lindau–Deficient Renal Cell Carcinoma

Maranchie, J. K., & Zhan, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2105 · Cited by 111 · see citing works

Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

Sutcliffe, A., Hollins, F., Gomez, E., Saunders, R. M., Doe, C., Cooke, M. S., Challiss, R. A. J., & Brightling, C. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1281oc · Cited by 109 · see citing works

ROS ‐generating oxidases N ox1 and N ox4 contribute to oncogenic R as‐induced premature senescence

Kodama, R., Kato, M., Furuta, S., Ueno, S., Zhang, Y., Matsuno, K., Yabe‐Nishimura, C., Tanaka, E., & Kamata, T. (2012) · Genes to Cells · doi:10.1111/gtc.12015 · Cited by 107 · see citing works

Role of NADPH Oxidases in Disturbed Flow- and BMP4- Induced Inflammation and Atherosclerosis

Jo, H., Song, H. W., & Mowbray, A. L. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1609 · Cited by 106 · see citing works

NADPH oxidase and cyclooxygenase mediate the ultraviolet B-induced generation of reactive oxygen species and activation of nuclear factor-κB in HaCaT human keratinocytes

Beak, S.-M., Lee, Y. S., & Kim, J. (2004) · Biochimie · doi:10.1016/j.biochi.2004.06.010 · Cited by 103 · see citing works

NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells

Stanicka, J., Russell, E. G., Woolley, J. F., & Cotter, T. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.510495 · Cited by 102 · see citing works

Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells

Boudreau, H. E., Casterline, B. W., Burke, D. J., & Leto, T. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.165 · Cited by 100 · see citing works

NADPH Oxidase 1 Mediates α-Synucleinopathy in Parkinson's Disease

Cristóvão, A. C., Guhathakurta, S., Bok, E., Je, G., Yoo, S. D., Choi, D., & Kim, Y. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2246-12.2012 · Cited by 99 · see citing works

Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production

Fitzgerald, J. P., Nayak, B., Shanmugasundaram, K., Friedrichs, W. E., Sudarshan, S., Eid, A. A., DeNapoli, T. S., Parekh, D. J., Gorin, Y. C., & Block, K. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030712 · Cited by 98 · see citing works

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

Anvari, E., Wikström, P., Walum, E., & Welsh, N. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1067697 · Cited by 96 · see citing works

A Constitutive NADPH Oxidase-Like System Containing gp91phox Homologs in Human Keratinocytes

Chamulitrat, W., Stremmel, W., Kawahara, T., Rokutan, K., Fujii, H. G., Wingler, K., Schmidt, H. H. H. W., & Schmidt, R. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22410.x · Cited by 96 · see citing works

NADPH Oxidase Is Involved in Prostaglandin F2α-induced Hypertrophy of Vascular Smooth Muscle Cells

Katsuyama, M., Fan, C., & Yabe-Nishimura, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111634200 · Cited by 95 · see citing works

Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases

Nakanishi, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500203 · Cited by 95 · see citing works

Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon

Fukuyama, M., Rokutan, K., Sano, T., Miyake, H., Shimada, M., & Tashiro, S. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.08.031 · Cited by 94 · see citing works

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

Vendrov, A. E., Madamanchi, N. R., Niu, X.-L., Molnar, K., Runge, M., Szyndralewiez, C., Page, P., & Runge, M. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143917 · Cited by 93 · see citing works

Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis

Bates, M. D., Erwin, C. R., Sanford, L. P., Wiginton, D. A., Bezerra, J. A., Schatzman, L. C., Jegga, A. G., Ebert, C., Williams, S. S., Steinbrecher, K. A., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32975 · Cited by 91 · see citing works

NOXious signaling in pain processing

Kallenborn-Gerhardt, W., Schröder, K., Geißlinger, G., & Schmidtko, A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.001 · Cited by 91 · see citing works

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro

Meng, D., Mei, A., Liu, J., Kang, X., Shi, X., Qian, R., & Chen, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048393 · Cited by 91 · see citing works

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

Crosas‐Molist, E., Bertrán, E., Sancho, P., López‐Luque, J., Fernando, J., Sánchez, A., Fernández, M., Navarro, E., & Fabregat, I. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.040 · Cited by 90 · see citing works

Targeting NOX enzymes in pulmonary fibrosis

Hecker, L., Cheng, J., & Thannickal, V. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1012-7 · Cited by 89 · see citing works

Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR

Briones, A. M., Tabet, F., Callera, G. E., Montezano, A. C. I., Yogi, Á., He, Y., Quinn, M. T., Salaíces, M., & Touyz, R. M. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.02.001 · Cited by 89 · see citing works

Mucosal reactive oxygen species are required for antiviral response: Role of duox in influenza a virus infection

Strengert, M., Jennings, R., Davanture, S., Hayes, P., Gabriel, G., & Knaus, U. G. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5353 · Cited by 88 · see citing works

Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.

Bokoch, G., & Prossnitz, V. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115599 · Cited by 86 · see citing works

Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors

Oshima, N., Yamada, Y., Nagayama, S., Kawada, K., Hasegawa, S., Okabe, H., Sakai, Y., & Aoi, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101735 · Cited by 84 · see citing works

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

Hironori Nakagami, A., Jensen, K. S., & Liao, J. K. (2003) · Annals of Medicine · doi:10.1080/07853890310001294 · Cited by 83 · see citing works

ROS signalling, NADPH oxidases and cancer

Landry, W. D., & Cotter, T. G. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140060 · Cited by 83 · see citing works

NAD(P)H Oxidase Activity of Nox4 in Chondrocytes Is Both Inducible and Involved in Collagenase Expression

Grange, L., Nguyen, M. V. C., Lardy, B., Derouazi, M., Campion, Y., Trocmé, C., Paclet, M., Gaudin, P., & Morel, F. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1485 · Cited by 81 · see citing works

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual nox4/nox1 inhibitors

Gaggini, F., Laleu, B., Orchard, M., Fioraso-Cartier, L., Cagnon, L., Houngninou-Molango, S., Gradia, A., Duboux, G., Merlot, C., Heitz, F., et al. (2011) · Bioorganic &amp; Medicinal Chemistry · doi:10.1016/j.bmc.2011.10.016 · Cited by 79 · see citing works

Targeting NADPH oxidases for the treatment of cancer and inflammation

Bonner, M. Y., & Arbiser, J. L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1017-2 · Cited by 77 · see citing works

Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

Deliyanti, D., & Wilkinson‐Berka, J. L. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0363-z · Cited by 77 · see citing works

A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation

Lee, J., Lim, E., Park, D., Lee, S.-H., Kim, J.-R., & Baek, S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.08.022 · Cited by 76 · see citing works

The ROS-NOX Connection in Cancer and Angiogenesis

Blanchetot, C., & Boonstra, J. (2008) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i1.30 · Cited by 76 · see citing works

Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach

Tominaga, K., Kawahara, T., Sano, T., Toida, K., Kuwano, Y., Sasaki, H., Kawai, T., Teshima-Kondo, S., & Rokutan, K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.029 · Cited by 74 · see citing works

NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer

Liu, X., Pei, C., Yan, S., Liu, G., Liu, G., Chen, W., Cui, Y., & Liu, Y. (2015) · Tumor Biology · doi:10.1007/s13277-014-2639-9 · Cited by 74 · see citing works

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

Gatto, G. J. J., Ao, Z., Kearse, M. G., Zhou, M., Morales, C. R., Daniels, E., Bradley, B. T., Goserud, M. T., Goodman, K. B., Douglas, S. A., et al. (2011) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.636360 · Cited by 74 · see citing works

Increased Expression of gp91phox Homologues of NAD(P)H Oxidase in the Aortic Media during Chronic Hypertension: Involvement of the Renin-Angiotensin System

Akasaki, T., Ohya, Y., Kuroda, J., Eto, K., Abe, I., Sumimoto, H., & Iida, M. (2006) · Hypertension Research · doi:10.1291/hypres.29.813 · Cited by 70 · see citing works

Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis

Crestani, B., Besnard, V., & Boczkowski, J. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.04.003 · Cited by 70 · see citing works

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Wani, R., Nagata, A., & Murray, B. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00224 · Cited by 70 · see citing works

Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury

Vecchione, C., Aretini, A., Marino, G., Bettarini, U., Poulet, R., Maffei, A., Sbroggió, M., Pastore, L., Gentile, M. T., Notte, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000200440.18768.30 · Cited by 70 · see citing works

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α

Gregg, J. L., Turner, R. M., Chang, G., Joshi, D., Zhan, Y., Chen, L., & Maranchie, J. K. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2979 · Cited by 68 · see citing works

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

Jayavelu, A. K., Müller, J. P., Bauer, R., Böhmer, S.-A., Lässig, J., Cerny‐Reiterer, S., Sperr, W. R., Valent, P., Maurer, B., Moriggl, R., et al. (2015) · Leukemia · doi:10.1038/leu.2015.234 · Cited by 67 · see citing works

Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

Felice, B. D., Garbi, C., Santoriello, M., Santillo, A., & Wilson, R. R. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0057-x · Cited by 67 · see citing works

MALONDIALDEHYDE STIMULATES COLLAGEN PRODUCTION BY HEPATIC LIPOCYTES ONLY UPON ACTIVATION IN PRIMARY CULTURE

Maher, J. J., Tzagarakis, C., & Giménez, A. (1994) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045590 · Cited by 67 · see citing works

A Reactive Oxygen Species–Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis

Spadoni, T., Svegliati, S., Amico, D., Albani, L., Moroncini, G., Avvedimento, E. V., & Gabrielli, A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39084 · Cited by 64 · see citing works

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

Doyle, T. M., Bryant, L., Muscoli, C., Cuzzocrea, S., Esposito, E., Chen, Z., & Salvemini, D. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.013 · Cited by 64 · see citing works

Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1

Teshima, S., Kutsumi, H., Kawahara, T., Kishi, K., & Rokutan, K. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.6.g1169 · Cited by 63 · see citing works

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice

Marco, E. D., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., Slattery, R. M., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3118-3 · Cited by 60 · see citing works

Involvement of NOX1/NADPH Oxidase in Morphine-Induced Analgesia and Tolerance

Ibi, M., Matsuno, K., Matsumoto, M., Sasaki, M., Nakagawa, T., Katsuyama, M., Iwata, K., Zhang, J., Kaneko, S., & Yabe‐Nishimura, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4136-11.2011 · Cited by 59 · see citing works

NADPH Oxidase 4-Derived H 2 O 2 Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy

Li, J., Wang, J. J., & Zhang, S. X. (2015) · Journal of Diabetes Research · doi:10.1155/2015/963289 · Cited by 58 · see citing works

Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis

Grygiel‐Górniak, B., & Puszczewicz, M. (2014) · Mediators of Inflammation · doi:10.1155/2014/389582 · Cited by 58 · see citing works

Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells

Deffert, C., Carnésecchi, S., Yuan, H., Rougemont, A., Kelkka, T., Holmdahl, R., Krause, K., & Schäppi, M. G. (2012) · The Journal of Pathology · doi:10.1002/path.4061 · Cited by 57 · see citing works

Role of Neuronal NADPH Oxidase 1 in the Peri-Infarct Regions after Stroke

Choi, D.-H., Kim, J.-H., Lee, K.-H., Kim, H.-Y., Kim, Y.-S., Choi, W. S., & Lee, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116814 · Cited by 56 · see citing works

XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species

Rezvani, H. R., Rossignol, R., Ali, N., Bénard, G., Tang, X., Yang, H. S., Jouary, T., de Verneuil, H., Taı̈eb, A., Kim, A. L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.12.006 · Cited by 56 · see citing works

Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?

Rezende, F., Löwe, O., Helfinger, V., Prior, K.-K., Walter, M., Zukunft, S., Fleming, I., Weißmann, N., Brandes, R. P., & Schröder, K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6314 · Cited by 55 · see citing works

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

Tréton, X., Pédruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., Fernandez, N., Bruyère, E., Woerther, P., Ducroc, R. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101669 · Cited by 55 · see citing works

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

Schildknecht, S., Weber, A., Gerding, H., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., & Leist, M. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990179 · Cited by 55 · see citing works

Small-Molecule Inhibitors of NADPH Oxidase 4

Borbély, G., Szabadkai, I., Horváth, Z., Markó, P., Varga, Z. V., Breza, N., Baska, F., Vántus, T., Huszár, M., Geiszt, M., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1004368 · Cited by 53 · see citing works

Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

Zanetti, F., Giacomello, M., Donati, Y. R. A., Carnésecchi, S., Frieden, M., & Barazzone‐Argiroffo, C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.002 · Cited by 52 · see citing works

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β

Piera-Velázquez, S., Makul, A., & Jiménez, S. A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39242 · Cited by 51 · see citing works

NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Sánchez-Sánchez, B., Gutiérrez-Herrero, S., López-Ruano, G., Prieto-Bermejo, R., Romo-González, M., Llanillo, M., Pandiella, A., Guerrero, C., Miguel, J. F. S., Sanchez-Guijo, F. M., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3044 · Cited by 51 · see citing works

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

Hirschhäuser, C., Bornbaum, J., Reis, A., Böhme, S., Kaludercic, N., Menabò, R., Lisa, F. D., Boengler, K., Shah, A. M., Schulz, R., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6238 · Cited by 50 · see citing works

NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents

Babalola, O., Mamalis, A., Lev‐Tov, H. A., & Jagdeo, J. R. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1416-8 · Cited by 47 · see citing works

A subset of N-substituted phenothiazines inhibits NADPH oxidases

Seredenina, T., Chiriano, G., Filippova, A., Nayernia, Z., Mahiout, Z., Fioraso-Cartier, L., Plastre, O., Scapozza, L., Krause, K.-H., & Jaquet, V. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.023 · Cited by 45 · see citing works

Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants

Dooley, A., Bruckdorfer, K. R., & Abraham, D. (2011) · Cardiology Research and Practice · doi:10.1155/2012/521958 · Cited by 43 · see citing works

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

Choi, D.-H., Kim, J.-H., Seo, J.-H., Lee, J., Choi, W. S., & Kim, Y.-S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115954 · Cited by 43 · see citing works

Nox4 supports proper capillary growth in exercise and retina neo‐vascularization

Vogel, J., Kruse, C., Zhang, M., & Schröder, K. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.284901 · Cited by 43 · see citing works

D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

Coustry, F., Posey, K. L., Liu, P., Alcorn, J. L., & Hecht, J. T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.033 · Cited by 42 · see citing works

Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900 · see citing works

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works

Oxidative stress in chronic kidney disease

Daenen, K., Andries, A., Mekahli, D., Schepdael, A. V., Jouret, F., & Bammens, B. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-4005-4 · Cited by 888 · see citing works

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works

Endothelial Cell Metabolism

Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works

Oxidative Stress and Hypertension

Griendling, K. K., Camargo, L. L., Rios, F. J. O., Alves-Lopes, R., Montezano, A. C. I., & Touyz, R. M. (2021) · Circulation Research · doi:10.1161/circresaha.121.318063 · Cited by 592 · see citing works

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Zhang, Y., Murugesan, P., Huang, K., & Cai, H. “. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0260-8 · Cited by 546 · see citing works

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

Tarafdar, A., & Pula, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123824 · Cited by 373 · see citing works

Oxidative stress in autoimmune rheumatic diseases

Smallwood, M. J., Nissim, A., Knight, A. R., Whiteman, M., Haigh, R. C., & Winyard, P. G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.086 · Cited by 347 · see citing works

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 353 · see citing works

Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases

Albano, G. D., Gagliardo, R. P., Montalbano, A. M., & Profita, M. (2022) · Antioxidants · doi:10.3390/antiox11112237 · Cited by 258 · see citing works

NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

Rastogi, R., Geng, X., Li, F., & Ding, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00301 · Cited by 249 · see citing works

Mechanisms of podocyte injury and implications for diabetic nephropathy

Barutta, F., Bellini, S., & Gruden, G. (2022) · Clinical Science · doi:10.1042/cs20210625 · Cited by 249 · see citing works

Understanding the role of neutrophils in acute respiratory distress syndrome

Yang, S.-C., Tsai, Y.-F., Pan, Y.-L., & Hwang, T. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.09.001 · Cited by 234 · see citing works

The superoxide radical switch in the biology of nitric oxide and peroxynitrite

Piacenza, L., Zeida, A., Trujillo, M., & Radí, R. (2022) · Physiological Reviews · doi:10.1152/physrev.00005.2022 · Cited by 204 · see citing works

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

Ung, L., Pattamatta, U., Carnt, N. A., Wilkinson‐Berka, J. L., Liew, G., & White, A. J. R. (2017) · Clinical Science · doi:10.1042/cs20171246 · Cited by 193 · see citing works

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

Augsburger, F., Филиппова, А., Rasti, D., Seredenina, T. S., Lam, M. A., Maghzal, G. J., Mahiout, Z., Jansen‐Dürr, P., Knaus, U. G., Doroshow, J. H., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101272 · Cited by 192 · see citing works

Crystal structures and atomic model of NADPH oxidase

Magnani, F., Nenci, S., Fañanás, E. M., Ceccon, M., Romero, E., Fraaije, M. W., & Mattevi, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702293114 · Cited by 187 · see citing works

The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review

Liu, L., Luo, P., Yang, M., Wang, J., Hou, W., & Xu, P. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1001212 · Cited by 174 · see citing works

Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Central d + Au Collisions at s N N = 200 GeV

Adare, A. M., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta’ani, H., Alexander, J., Andrews, K. R., Angerami, A., et al. (2015) · Physical Review Letters · doi:10.1103/physrevlett.114.192301 · Cited by 172 · see citing works

Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 169 · see citing works

NADPH oxidases in Parkinson’s disease: a systematic review

Bélarbi, K., Cuvelier, E., Destée, A., Gressier, B., & Chartier‐Harlin, M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0225-5 · Cited by 158 · see citing works

Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease

Ganguly, U., Kaur, U., Chakrabarti, S. S., Sharma, P., Agrawal, B. K., Saso, L., & Chakrabarti, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7086512 · Cited by 150 · see citing works

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis

Doridot, L., Jeljeli, M. M., Chêne, C., & Batteux, F. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101122 · Cited by 142 · see citing works

Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling

Kalyanaraman, B., Hardy, M., Podsiadły, R., Cheng, G., & Zielonka, J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.08.021 · Cited by 137 · see citing works

Dysregulation of metabolic pathways in pulmonary fibrosis

Rajesh, R., Atallah, R., & Bärnthaler, T. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108436 · Cited by 127 · see citing works

NOX5: Molecular biology and pathophysiology

Touyz, R. M., Anagnostopoulou, A., Rios, F. J. O., Montezano, A. C. I., & Camargo, L. L. (2019) · Experimental Physiology · doi:10.1113/ep086204 · Cited by 129 · see citing works

On the Clinical Pharmacology of Reactive Oxygen Species

Casas, A. I., Nogales, C., Mucke, H. A., Petraina, A., Cuadrado, A., Rojo, A. I., Ghezzi, P., Jaquet, V., Augsburger, F., Dufrasne, F., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019422 · Cited by 128 · see citing works

Nox4 in renal diseases: An update

Yang, Q., Wu, F.-R., Wang, J.-N., Gao, L., Jiang, L., Li, H.-D., Ma, Q., Liu, X., Wei, B., Zhou, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.042 · Cited by 120 · see citing works

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

Reis, J., Massari, M., Marchese, S., Ceccon, M., Aalbers, F. S., Corana, F., Valente, S., Mai, A., Magnani, F., & Mattevi, A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101466 · Cited by 125 · see citing works

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low‐Grade Inflammation in Osteoarthritis

Minguzzi, M., Cetrullo, S., D’Adamo, S., Silvestri, Y., Flamigni, F., & Borzı̀, R. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3075293 · Cited by 110 · see citing works

NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension

Knock, G. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.029 · Cited by 108 · see citing works

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

Yu, M., Wang, Z., Wang, D., Aierxi, M., Ma, Z., & Wang, Y. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25221 · Cited by 106 · see citing works

Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies

Teixeira-Santos, L., Albino‐Teixeira, A., & Pinho, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105280 · Cited by 103 · see citing works

NADPH oxidases: redox regulation of cell homeostasis and disease

Kračun, D., Lopes, L. R., Cifuentes-Pagano, E., & Pagano, P. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00034.2023 · Cited by 104 · see citing works

Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression

Pourgholamhossein, F., Rasooli, R., Pournamdari, M., Pourgholi, L., Fekri, M. S., Ghazi‐Khansari, M., Iranpour, M., Poursalehi, H. R., Heidari, M. R., & Mandegary, A. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.034 · Cited by 100 · see citing works

NADPH Oxidases and Their Role in Atherosclerosis

Poznyak, A. V., Grechko, A. V., Orekhova, V. A., Khotina, V. A., Ivanova, E. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8070206 · Cited by 95 · see citing works

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease

Touyz, R. M., Anagnostopoulou, A., Camargo, L. L., Rios, F. J. O., & Montezano, A. C. I. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7583 · Cited by 91 · see citing works

Nitric Oxide-cGMP Signaling in Hypertension

Ataabadi, E. A., Golshiri, K., Jüttner, A. A., Krenning, G., Danser, A. H. J., & Roks, A. J. M. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15856 · Cited by 91 · see citing works

Reactive Oxygen Species: Not Omnipresent but Important in Many Locations

Herb, M., Gluschko, A., & Schramm, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716406 · Cited by 88 · see citing works

Upconversion of Reductants

Syroeshkin, M. A., Kuriakose, F., Saverina, E. A., Timofeeva, V. A., Egorov, M. P., & Alabugin, I. V. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201807247 · Cited by 88 · see citing works

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH

Chen, W., Guo, C., Huang, S., Jia, Z., Wang, J., Zhong, J., Ge, H., Yuan, J., Chen, T., Liu, X., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105122 · Cited by 80 · see citing works

The role of NADPH oxidases in diabetic cardiomyopathy

Hansen, S. S., Aasum, E., & Hafstad, A. D. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.025 · Cited by 77 · see citing works

Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome

Held, J. M. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7725 · Cited by 73 · see citing works

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Wu, X., Zhou, Z., Li, K., & Liu, S. (2024) · Advanced Science · doi:10.1002/advs.202308632 · Cited by 71 · see citing works

Oxidative Stress and the Role of NADPH Oxidase in Glaucoma

Gaskin, J. C. F., Shah, M. H., & Chan, E. C. (2021) · Antioxidants · doi:10.3390/antiox10020238 · Cited by 75 · see citing works

Dual oxidase: a novel therapeutic target in allergic disease

van der Vliet, A., Danyal, K., & Heppner, D. E. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14158 · Cited by 70 · see citing works

Anti-fibrotic treatments: A review of clinical evidence

Allinovi, M., Chiara, L. D., Angelotti, M. L., Becherucci, F., & Romagnani, P. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.017 · Cited by 68 · see citing works

NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis

Kato, K., & Hecker, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101541 · Cited by 67 · see citing works

Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease

Fadini, G. P., Spinetti, G., Santopaolo, M., & Madeddu, P. R. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312863 · Cited by 66 · see citing works

<scp>Pre‐clinical</scp> evidence of a dual <scp>NADPH</scp> oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis

Thannickal, V. J., Jandeleit‐Dahm, K., Szyndralewiez, C., & Török, N. J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17649 · Cited by 65 · see citing works

Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms

Dolunay, A., Şenol, Ş. P., Temiz-Reşitoğlu, M., Güden, D. S., Sari, A. N., Şahan-Fırat, S., & Tunçtan, B. (2016) · Inflammation · doi:10.1007/s10753-016-0483-3 · Cited by 65 · see citing works

Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction

Lee, H., & José, P. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.670076 · Cited by 63 · see citing works

Inhibiting NADPH Oxidases to Target Vascular and Other Pathologies: An Update on Recent Experimental and Clinical Studies

Sylvester, A. L., Zhang, D. X., Ran, S., & Zinkevich, N. S. (2022) · Biomolecules · doi:10.3390/biom12060823 · Cited by 62 · see citing works

NADPH Oxidase Inhibition: Preclinical and Clinical Studies in Diabetic Complications

Urner, S., Ho, F., Jha, J. C., Ziegler, D., & Jandeleit-Dahm, K. A. M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8047 · Cited by 64 · see citing works

Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy

Zhu, L., Zhao, Y., Liu, T., Chen, M., Qian, W. P., Jiang, B., Barwick, B. G., Zhang, L., Styblo, T. M., Li, X., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c07440 · Cited by 61 · see citing works

Therapeutic pro-fibrogenic signaling pathways in fibroblasts

Cannito, S., Novo, E., & Parola, M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.017 · Cited by 60 · see citing works

The Dual Role of Reactive Oxygen Species-Generating Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Gastrointestinal Inflammation and Therapeutic Perspectives

Dang, P. M., Rolas, L., & Benna, J. E. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8018 · Cited by 61 · see citing works

Molecular insights of NADPH oxidases and its pathological consequences

Waghela, B. N., Vaidya, F. U., Agrawal, Y., Santra, M. K., Mishra, V., & Pathak, C. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3589 · Cited by 59 · see citing works

CircRNA–miRNA networks in regulating bone disease

Huang, W., Wu, Y., Qiao, M., Xie, Z., Cen, X. B., Huang, X., & Zhao, Z. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30625 · Cited by 56 · see citing works

Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways

Jha, J. C., Dai, A., Garzarella, J., Charlton, A., Urner, S., Østergaard, J. A., Okabe, J., Holterman, C. E., Skene, A., Power, D. A., et al. (2022) · Diabetes · doi:10.2337/db21-1079 · Cited by 58 · see citing works

Targeting the Redox Landscape in Cancer Therapy

Narayanan, D., Ma, S., & Özcelik, D. (2020) · Cancers · doi:10.3390/cancers12071706 · Cited by 54 · see citing works

Oxidative stress and its possible relation to lower urinary tract functional pathology

Andersson, K. (2017) · British Journal of Urology · doi:10.1111/bju.14063 · Cited by 53 · see citing works

The current landscape of antifibrotic therapy across different organs: A systematic approach

Fuster‐Martínez, I., & Calatayud, S. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107245 · Cited by 52 · see citing works

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Schwaerzer, G. K., Kalyanaraman, H., Casteel, D. E., Dalton, N. D., Gu, Y., Lee, S., Zhuang, S., Wahwah, N., Schilling, J. M., Patel, H. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11389-1 · Cited by 50 · see citing works

Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?

Victoni, T., Barreto, E., Lagente, V., & Carvalho, V. F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6646923 · Cited by 54 · see citing works

NOX4 is an early initiator of neuropathic pain

Geis, C., Geuß, E., Sommer, C., Schmidt, H. H. H. W., & Kleinschnitz, C. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.11.008 · Cited by 49 · see citing works

The Nox1/Nox4 inhibitor attenuates acute lung injury induced by ischemia-reperfusion in mice

Cui, Y., Wang, Y., Li, G., Wan, M., Zhou, X., Wang, J., & Liu, B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209444 · Cited by 49 · see citing works

Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice

Chen, W., Guo, C., Jia, Z., Wang, J., Xia, M., Li, C., Li, M., Yin, Y., Tang, X., Chen, T., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8285065 · Cited by 44 · see citing works

NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis

Svegliati, S., Spadoni, T., Moroncini, G., & Gabrielli, A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.554 · Cited by 46 · see citing works

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

Santos, M. D. S., Salomon, D., & Orth, K. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006438 · Cited by 46 · see citing works

New opportunities for targeting redox dysregulation in cardiovascular disease

Bubb, K. J., Drummond, G. R., & Figtree, G. A. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz183 · Cited by 48 · see citing works

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension

Huetsch, J., Suresh, K. S., & Shimoda, L. A. (2019) · Antioxidants · doi:10.3390/antiox8030056 · Cited by 42 · see citing works

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

Murphy‐Marshman, H., Quensel, K., Shiwen, X., Barnfield, R., Kelly, J., Peidl, A., Stratton, R. J., & Leask, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186740 · Cited by 38 · see citing works

Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy

Hou, L., Zhang, L., Hong, J., Zhang, D., Zhao, J., & Wang, Q. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.8014 · Cited by 39 · see citing works

Stressed out - The role of oxidative stress in airway smooth muscle dysfunction in asthma and COPD

Saunders, R. M., Biddle, M., Amrani, Y., & Brightling, C. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.04.011 · Cited by 38 · see citing works

Contribution of Oxidative Stress (OS) in Calcific Aortic Valve Disease (CAVD): From Pathophysiology to Therapeutic Targets

Tănase, D. M., Valasciuc, E., Gosav, E. M., Floria, M., Costea, C. F., Dima, N., Tudorancea, I., Maranducă, M. A., & Șerban, I. L. (2022) · Cells · doi:10.3390/cells11172663 · Cited by 37 · see citing works

Oxidative Stress and Endoplasmic Reticular Stress Interplay in the Vasculopathy of Hypertension

Camargo, L. L., Wang, Y., Rios, F. J. O., McBride, M., Montezano, A. C. I., & Touyz, R. M. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.10.012 · Cited by 35 · see citing works

NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction

Elumalai, S., Karunakaran, U., Moon, J. S., & Won, K. C. (2021) · Cells · doi:10.3390/cells10071573 · Cited by 36 · see citing works

Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus

Akoumianakis, I., & Antoniades, C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37 · see citing works

Ibudilast attenuates doxorubicin‐induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga‐Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Matsunaga, N., Koyanagi, S., Azuma, Y., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14777 · Cited by 35 · see citing works

NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model

Emmert, H., Fonfara, M., Rodríguez, E., & Weidinger, S. (2020) · Experimental Dermatology · doi:10.1111/exd.14148 · Cited by 34 · see citing works

NADPH Oxidase Inhibition in Fibrotic Pathologies

Bernard, K. F., & Thannickal, V. J. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8032 · Cited by 33 · see citing works

Resuscitating the Globally Ischemic Brain: TTM and Beyond

Hosseini, M., Wilson, R. H., Crouzet, C., Amirhekmat, A., Wei, K. S., & Akbari, Y. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00856-z · Cited by 32 · see citing works

Platelet Hyperreactivity in Diabetes: Focus on GPVI Signaling—Are Useful Drugs Already Available?

Arthur, J. F., Jandeleit-Dahm, K. A. M., & Andrews, R. K. (2016) · Diabetes · doi:10.2337/db16-1098 · Cited by 31 · see citing works

Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells

Appukuttan, B., Ma, Y., Stempel, A. J., Ashander, L. M., Deliyanti, D., Wilkinson‐Berka, J. L., & Smith, J. R. (2018) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.13155 · Cited by 31 · see citing works

Fibroblasts and their responses to chronic injury in pulmonary fibrosis

Wu, B., Tang, L. F., & Kapoor, M. (2020) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.12.003 · Cited by 33 · see citing works

Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice

de Oliveira, M. G., Mónica, F. Z., Passos, G. R., Victorio, J. A., Davel, A. P., Oliveira, A. L. L., Parada, C. A., D’Ancona, C. A. L., Hill, W. G., & Antunes, E. (2022) · Antioxidants · doi:10.3390/antiox12010092 · Cited by 28 · see citing works

S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization

Boutin, J. A., Bouillaud, F., Janda, E., Gacsályi, I., Guillaumet, G., Hirsch, É. C., Kane, D. A., Nepveu, F., Reybier, K., Dupuis, P., et al. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.114231 · Cited by 29 · see citing works

Cardiovascular protection by Nox4

Morawietz, H. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx252 · Cited by 28 · see citing works

NADPH oxidases in bone and cartilage homeostasis and disease: A promising therapeutic target

Wegner, A. M., & Haudenschild, D. R. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24693 · Cited by 27 · see citing works

Reactive Oxygen Species Signaling Promotes Hypoxia-Inducible Factor 1 α Stabilization in Sonic Hedgehog-Driven Cerebellar Progenitor Cell Proliferation

Eyrich, N. W., Potts, C. R., Robinson, M. H., Maximov, V. D., & Kenney, A. M. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00268-18 · Cited by 27 · see citing works

NADPH Oxidases and Their Roles in Skin Homeostasis and Carcinogenesis

Rudolf, J., Raad, H., Taı̈eb, A., & Rezvani, H. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7282 · Cited by 26 · see citing works

5‐Hydroxytryptamine (5‐HT)‐exacerbated DSS‐induced colitis is associated with elevated NADPH oxidase expression in the colon

Dong, S., Chen, M., Dai, F., Xuan, Q., Chen, P., Feng, D., Gao, L., Zhu, C., Chang, Y., Chu, F., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28198 · Cited by 25 · see citing works

NADPH Oxidase Mediates Membrane Androgen Receptor–Induced Neurodegeneration

Tenkorang, M. A. A., Duong, P., & Cunningham, R. L. (2019) · Endocrinology · doi:10.1210/en.2018-01079 · Cited by 26 · see citing works

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Wegner, A. M., Campos, N. R., Robbins, M. A., Haddad, A. F., Cunningham, H. C., Yik, J. H. N., Christiansen, B., & Haudenschild, D. R. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24417 · Cited by 24 · see citing works

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific Contributions

Kim, J., & Moon, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212299 · Cited by 23 · see citing works

Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells

Liao, J., Lai, Z., Huang, G., Lin, J., Huang, W. H., Qin, Y., Chen, Q., Hu, Y., Cheng, Q., Jiang, L., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116042 · Cited by 22 · see citing works

Oxidative Stress in Antigen Processing and Presentation

Chang, Q., Zhang, Y., Liu, X., Miao, P., Pu, W., Liu, S., Zhang, J., Yuan, T., Shen, G., & Xie, N. (2025) · MedComm – Oncology · doi:10.1002/mog2.70020 · Cited by 21 · see citing works

KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses

Finetti, F., Schiavo, I., Ercoli, J., Zotta, A., Boda, E., Retta, S. F., & Trabalzini, L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109527 · Cited by 21 · see citing works

Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement

Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521 · see citing works

History of the research on NOX/NADPH oxidase and the trend of its inhibitor development

Katsuyama, M. (2022) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.95.0_1-s04-1

[Research progress of NADPH oxidases and their inhibitors].

Yang, X.-L., Chen, Y.-J., Hu, G., & Li, Q. (2016) · PubMed · Cited by 3 · see citing works

The NADPH Oxidase Family and Its Inhibitors

Chocry, M., & Leloup, L. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7915 · Cited by 89 · see citing works

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371 · see citing works