The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
P2X receptor channels in chronic pain pathways
Open accessAbstract
Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signalling through excitatory and calcium‐permeable P2X receptor channels is now rightfully considered as a critical player in pathological pain generation and maintenance; therefore, their selective targeting represents a therapeutic opportunity with promising yet untapped potential. Recent advances in the structural, functional and pharmacological characterization of rodent and human ATP‐gated P2X receptor channels have shed brighter light on the role of specific subtypes in the pathophysiology of chronic inflammatory, neuropathic or cancer pain. Here, we will review the contribution of P2X3, P2X4 and P2X7 receptors to chronic pain and discuss the opportunities and challenges associated with the pharmacological manipulation of their function. Linked Articles: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc
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Citations
Cites
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
Clark, A. K., Staniland, A. A., Marchand, F., Kaan, T. K. Y., McMahon, S. B., & Malcangio, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3295-09.2010 · Cited by 291 · cited 1×
“It was later reported that LPS priming of microglia in the spinal cord is necessary for the P2X7/IL-1β release pathway to take place (Clark et al., 2010).”
BackgroundThe P2X7 Receptor-Interleukin-1 Liaison
Giuliani, A. L., Sarti, A. C., Falzoni, S., & Di Virgilio, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00123 · Cited by 166
Cited by
Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534
Challenges of neuropathic pain: focus on diabetic neuropathy
Rosenberger, D. C., Blechschmidt, V., Timmerman, H., Wolff, A., & Treede, R.-D. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02145-7 · Cited by 325
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illes, P., Müller, C. E., Jacobson, K. A., Grutter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilkovic, S. S., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15299 · Cited by 313
Metadata
- Authors
- Bernier, L., Ase, A. R., & Séguéla, P.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2017-08-17
- Volume
- 175
- Issue
- 12
- Pages
- 2219-2230
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2736658723
- Cited by
- 200
- References
- 3
- FWCI
- 12.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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