The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Gene aberrations for precision medicine against lung adenocarcinoma
Open accessAbstract
Lung adenocarcinoma (LADC), the most frequent histological type of lung cancer, is often triggered by an aberration in a driver oncogene in tumor cells. Examples of such aberrations are EGFR mutation and ALK fusion. Lung adenocarcinoma harboring such mutations can be treated with anticancer drugs that target the aberrant gene products. Additional oncogene aberrations, including RET, ROS 1, and NRG 1 fusions, skipping of exon 14 of MET, and mutations in BRAF, HER 2, NF 1, and MEK 1, were recently added to the list of such “druggable” driver oncogene aberrations, and their responses to targeted therapies are currently being evaluated in clinical trials. However, approximately 30% and 50% of LADC s in patients in Japan and Europe/USA, respectively, lack the driver oncogene aberrations listed above. Therefore, novel therapeutic strategies, such as those that exploit the vulnerabilities of cancer cells with non‐oncogene aberrations, are urgently required. This review summarizes the current status of research on precision medicine against LADC and enumerates the research priorities for the near future.
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Cites
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
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Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732
Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR
Maemondo, M., Inoue, A., Kobayashi, K., Sugawara, S., Oizumi, S., Isobe, H., Gemma, A., Harada, M., Yoshizawa, H., Kinoshita, I., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909530 · Cited by 5,525
Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer
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Characterizing the cancer genome in lung adenocarcinoma
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Metadata
- Authors
- Saito, M., Shiraishi, K., Kunitoh, H., Takenoshita, S., Yokota, J., & Kohno, T.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2016-05-25
- Volume
- 107
- Issue
- 6
- Pages
- 713-720
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- OpenAlex
- W2322556414
- Cited by
- 240
- References
- 7
- FWCI
- 20.39
- Type
- journal article
- Language
- en
- Open access
- gold
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