Tryptase release does not discriminate between IgE- and MRGPRX2-mediated activation in human mast cells

Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions

McNeil, B. D., Pundir, P., Meeker, S., Han, L., Undem, B., Kulka, M., & Dong, X.-Z. (2014) · Nature · doi:10.1038/nature14022 · Cited by 1,164

Different activation signals induce distinct mast cell degranulation strategies

Gaudenzio, N., Sibilano, R., Marichal, T., Starkl, P. M., Reber, L. L., Cénac, N., McNeil, B. D., Dong, X., Hernandez, J. D., Sagi‐Eisenberg, R., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85538 · Cited by 380

Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch

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IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

Joulia, R., L'Faqihi, F.-E., Valitutti, S., & Espinosa, É. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.049 · Cited by 101

Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones

Elst, J., Maurer, M., Sabato, V., Faber, M. A., Bridts, C. H., Mertens, C. H., Houdt, M. V., Gasse, A. L. V., van der Poorten, M. M., Puysseleyr, L. P. D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.668962 · Cited by 65

MRGPRX2 and Immediate Drug Hypersensitivity: Insights From Cultured Human Mast Cells

Elst, J., Sabato, V., Faber, M. A., Bridts, C. H., Mertens, C. H., Houdt, M. V., Gasse, A. L. V., Hagendorens, M. M., Tendeloo, V. F. V., Maurer, M., et al. (2020) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0557 · Cited by 48

Influence of IL‐6, IL‐33, and TNF‐α on human mast cell activation: Lessons from single cell analysis by flow cytometry

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Immunoglobulin E cross-linking or MRGPRX2 activation: clinical insights from rocuronium hypersensitivity

Ebo, D. G., van der Poorten, M. M., Elst, J., Gasse, A. L. V., Mertens, C. H., Bridts, C. H., Garvey, L. H., Horiuchi, T., & Sabato, V. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.10.006 · Cited by 46

Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception

Yang, S., Liu, Y., Lin, A. A., Cavalli-Sforza, L. L., Zhao, Z., & Su, B. (2005) · Gene · doi:10.1016/j.gene.2005.03.001 · Cited by 37

Phenotypic and functional characterization of in vitro cultured human mast cells

Cop, N., Decuyper, I. I., Faber, M., Sabato, V., Bridts, C., Hagendorens, M. M., Winter, B. Y. D., Clerck, L. D., & Ebo, D. G. (2016) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21399 · Cited by 22

Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond

Vitte, J., Vibhushan, S., Bratti, M., Montero-Hernández, J. E., & Blank, U. (2022) · Medical Principles and Practice · doi:10.1159/000527481 · Cited by 110

Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies

Toscano, A., Elst, J., Gasse, A. L. V., Beyens, M. M. J., van der Poorten, M. M., Bridts, C. H., Mertens, C. H., Houdt, M. V., Hagendorens, M. M., Remoortel, S. V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026304 · Cited by 37

Allergenic and Mas-Related G Protein-Coupled Receptor X2-Activating Properties of Drugs: Resolving the Two

Sabato, V., Ebo, D. G., van der Poorten, M. M., Toscano, A., Gasse, A. L. V., Mertens, C. H., Houdt, M. V., Beyens, M. M. J., & Elst, J. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.12.014 · Cited by 35

Non–IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions

Arango, S. A., Kumar, M., Chow, T. G., & Sabato, V. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.02.019 · Cited by 33

Opioid toxicity: histamine, hypersensitivity, and MRGPRX2

Baldo, B. A., & Pham, N. H. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03402-2 · Cited by 31

Biomarkers of immediate drug hypersensitivity

Mayorga, C., Ariza, A., Muñoz‐Cano, R., Sabato, V., Doña, I., & Torres, M. J. (2023) · Allergy · doi:10.1111/all.15933 · Cited by 27

Recent Knowledge and Insights on the Mechanisms of Immediate Hypersensitivity and Anaphylaxis: IgE/FcεRI- and Non-IgE/FcεRI-Dependent Anaphylaxis

Ebo, D. G., Beyens, M. M. J., Heremans, K., van der Poorten, M. M., Gasse, A. L. V., Mertens, C. H., Houdt, M. V., Sabato, V., & Elst, J. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221025091827 · Cited by 21

Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders

Beyens, M., Toscano, A., Ebo, D., Gülen, T., & Sabato, V. (2023) · Diagnostics · doi:10.3390/diagnostics13243662 · Cited by 22

Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An EAACI Task Force Report

Mayorga, C., Fernández‐Santamaría, R., Çelík, G., Labella, M., Murdaca, G., Sokołowska, M., Naisbitt, D. J., & Sabato, V. (2025) · Allergy · doi:10.1111/all.16576 · Cited by 19

Paediatric perioperative hypersensitivity: the performance of the current consensus formula and the effect of uneventful anaesthesia on serum tryptase

Vlaeminck, N., van der Poorten, M. M., Madsen, C. N., Melchiors, B. B., Michel, M., Gonzalez, C., Schrijvers, R., Elst, J., Mertens, C. H., Saldien, V., et al. (2024) · BJA Open · doi:10.1016/j.bjao.2023.100254 · Cited by 13

Update on desensitization to chemotherapeutics and biologicals

Caiado, J., & Castells, M. (2025) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2025.07.018 · Cited by 10

What the clinician should know when ordering a mast cell tryptase test

Michel, M., Giusti, D., Klingebiel, C., Pham, B., & Vitte, J. (2025) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2025.03.003 · Cited by 8

Immediate hypersensitivity reactions to antineoplastic agents – A practical guide for the oncologist

Seghers, S., Teuwen, L.-A. M. N., Beyens, M. M. J., Blick, D. D., Sabato, V., Ebo, D. G., & Prenen, H. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102559 · Cited by 8

Diagnosis of Quinolone Hypersensitivity: An EAACI Position Paper

Gelincik, A. A., Brockow, K., Çelík, G., Demir, S., Doña, I., Ebo, D. G., Mayorga, C., Labella, M., Sabato, V., & Torres, M. J. (2025) · Allergy · doi:10.1111/all.70037 · Cited by 5

Human mast cells in anaphylaxis: from research to diagnosis

Elst, J., Ebo, D. G., & Sabato, V. (2025) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000001092 · Cited by 5

Hypersensitivity reactions to folinic acid: mechanisms involved based on two case reports and a literature review

Apraxine, M., den Eynde, M. V., Cuyper, A. D., & Pirson, F. (2022) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-022-00752-5 · Cited by 5

Immediate hypersensitivity to COVID-19 vaccines: Focus on biological diagnosis

Nicaise‐Roland, P., Granger, V., Soria, A., Barbaud, A. M., Pallardy, M. J., Chollet‐Martin, S., & de Chaisemartin, L. (2022) · Frontiers in Allergy · doi:10.3389/falgy.2022.1007602 · Cited by 4

Serum tryptase and drug hypersensitivity: why, how and what? A systematic review

Klingebiel, C., Belhocine, W., & Vitte, J. (2023) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000916 · Cited by 2

Tryptase in drug-induced anaphylaxis: the need for acute and baseline values

Michel, M., Giusti, D., Klingebiel, C., & Vitte, J. (2024) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000001012 · Cited by 2

MRGPRX2 ‐Mediated Mast Cell Degranulation by Monomethyl Methacrylate: Unveiling a Pathway in Bone Cement Implantation Syndrome

Suzuki, Y., Liu, S., Takemasa, E., Takasaki, Y., Yorozuya, T., & Mogi, M. (2025) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.70046 · Cited by 1

A quarter of a century fundamental and translational research in perioperative hypersensitivity and anaphylaxis at the Antwerp university hospital, a Belgian Centre of Excellence of the World Allergy Organization

Ebo, D. G., Vlaeminck, N., van der Poorten, M. M., Elst, J., Toscano, A., Gasse, A. L. V., Hagendorens, M. M., Aerts, S., Adriaensens, I., Saldien, V., et al. (2023) · World Allergy Organization Journal · doi:10.1016/j.waojou.2023.100759 · Cited by 3

Propriétés allergiques et activatrices de MRGPRX2 des médicaments : vers un algorithme mécanistique résolutif

Ebo, D. G., Elst, J., van der Poorten, M. M., Toscano, A., Gasse, A. L. V., Mertens, C. H., Houdt, M. V., Beyens, M. M. J., & Sabato, V. (2024) · Revue française d'allergologie · doi:10.1016/j.reval.2024.104121

Pediatric ondansetron hypersensitivity: Clinical features and a preliminary diagnostic approach

Geniş, C., Özel, Ç. T., Selmanoğlu, A., Emeksiz, Z. Ş., & Mısırlıoğlu, E. D. (2025) · Allergy and Asthma Proceedings · doi:10.2500/aap.2025.46.250057

Levels of tryptase, chymase, and FcϵRIα messenger RNA in human skin are unchanged after IgE-dependent stimulation of cutaneous mast cells in vivo

Xiaa, H.-Z., Zweiman, B., & Schwartz, L. B. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70100-3 · Cited by 5

Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function

Varricchi, G., Pecoraro, A., Loffredo, S., Poto, R., Rivellese, F., Genovese, A., Marone, G., & Spadaro, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00299 · Cited by 111

Degradation of Monocyte Chemoattractant Protein-1 by Tryptase Co-Released in Immunoglobulin E-Dependent Activation of Primary Human Cultured Mast Cells

Tam, I. Y. S., Ng, C. W., Lau, H. Y. A., & Tam, S. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000490533 · Cited by 10

α and β Tryptase Is Released From Mast Cells by IgE Cross-linking and Increased α/β Ratio Is Associated With Diminished PAR-2 Activity

Rathore, N., Liu, P., Maun, H. R., Lazarus, R., Arnott, D., & Choy, D. (2023) · doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3041

Tryptase and chymase, markers of distinct types of human mast cells

Craig, S. S., & Schwartz, L. B. (1989) · Immunologic Research · doi:10.1007/bf02919075 · Cited by 74