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Cited by 7Sexual Differentiation and DisordersAdrenal Hormones and DisordersMetabolism and Genetic Disorders

Risk factors for hospitalization of children with congenital adrenal hyperplasia

Yang, Ming, White, Perrin C.·2017·Clinical Endocrinology
DOI 10.1111/cen.13309
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Abstract

BACKGROUND AND OBJECTIVES: Patients with congenital adrenal hyperplasia (CAH) owing to 21-hydroxylase deficiency are prone to potentially life-threatening adrenal crises. We tried to identify risk factors for postdiagnosis hospitalization for children with the salt-wasting form of CAH. METHODS: We reviewed medical records of all children who presented to Children's Medical Center, Dallas, from 1999 to 2013 with CAH (ICD-9 code 255·2). RESULTS: Five hundred and twenty-two unique patients were coded for ICD-9 code of 255·2 (CAH) from 1999 to 2013; 155 patients had salt-wasting disease. Fifty-five patients were hospitalized a total of 105 times. Patients who were hospitalized were more likely to have noncommercial insurance (RR = 1·8; 95% CI [1·1-2·8]; P = 0·02); this included five patients hospitalized a total of 37 times. Children younger than 2 years (RR = 3·3 [2·2-4·8]; P < 0·0001) were more likely to be hospitalized. In a nested case-control analysis, the risk of hospitalization was correlated with daily fludrocortisone dose (P ≤ 0·0001) but not hydrocortisone dose; no outpatient laboratory test predicted hospitalization. Gastroenteritis was the most frequent admitting diagnosis. CONCLUSIONS: Younger children may be at greater risk of hospitalization owing to increased susceptibility to viral infections and decreased ability to withstand stress and dehydration. A minority of patients with noncommercial insurance may have higher risk owing to social barriers that interfere with treatment compliance. Those requiring higher daily fludrocortisone dosages likely have inherently more severe disease leading to higher rates of hospitalization.

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Authors
Yang, M., & White, P. C.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
White, Perrin C.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2017-03-09
Volume
86
Issue
5
Pages
669-673
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/cen.13309
OpenAlex
W2588879072
Cited by
7
References
15
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 3
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Janssen Scientific Affairs, LLC
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, salt-wasting CAH, hospitalization risk factors, pediatric patients, hydrocortisone dose, insurance status, gastroenteritis, viral infection, dehydration, medication adherence
MeSH terms
Adolescent, Adrenal Hyperplasia, Congenital, Adult, Child, Child, Preschool, Female, Hospitalization, Humans, Infant, Male, Risk Factors, Texas, Young Adult

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