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Cited by 7Adrenal Hormones and DisordersSexual Differentiation and DisordersStress Responses and Cortisol

The effect of patient-managed stress dosing on electrolytes and blood pressure in acute illness in children with adrenal insufficiency

Chrisp, Georgina L, Torpy, David J, Maguire, Ann M, Quartararo, Maria, Falhammar, Henrik, King, Bruce R, Munns, Craig F, Hameed, Shihab +1 more·2020·Clinical Endocrinology
DOI 10.1111/cen.14196
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Abstract

BACKGROUND: Adrenal crises (AC) are acute episodes of adrenal insufficiency (AI). Manifestations include hypotension and electrolyte disturbances. Glucocorticoid stress dosing (SD) can prevent AC progression, but its effect on physiological parameters has not been assessed in a 'real world setting'. AIMS: To assess the effect of prior self-managed glucocorticoid dose escalation on physiological markers in children with congenital adrenal hyperplasia (CAH) presenting to hospital for an acute illness. METHODS: An audit of records of all children with CAH presenting to paediatric referral hospital between 2000 and 2015. Potassium, sodium and glucose levels, and hypotension were compared between children who had and had not used SD. RESULTS: There were 321 attendances by patients with CAH and an acute illness during the study period. Any form of SD was used by 64.2% (n = 206); intramuscular (IM) hydrocortisone was used by 22.1% (n = 71) and oral only by 41.7% (n = 134). Use of SD (oral and/or IM) was associated with a significantly lower mean potassium level (4.02 ± 0.71 vs. 4.27 ± 0.79 mmol/l, P < .05). Linear regression analysis showed that age (beta: -0.04 years (95% CI -0.06, -0.02)), diarrhoea (beta: -0.41 (95% CI -0.06, -0.02)) and any form of stress dosing (oral, IM or both) (beta: -0.29 (95% CI -0.55, -0.04)) were each independently and significantly associated with potassium levels. SD was not significantly associated with sodium or glucose concentrations or with estimates of hypotension. CONCLUSION: Patient-initiated SD resulted in a significant reduction in hyperkalaemia and lowered mean potassium levels in paediatric patients with CAH but did not alter significantly sodium and glucose concentrations or incidences of hypotension.

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Crossref · 10.1111/cen.14196

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Authors
Chrisp, G. L., Torpy, D. J., Maguire, A. M., Quartararo, M., Falhammar, H., King, B. R., Munns, C. F., Hameed, S., & Rushworth, R. L.
Affiliations
  • The University of Notre Dame Australia (AU)
  • Royal Adelaide Hospital (AU)
  • The University of Sydney (AU)
  • Karolinska University Hospital (SE)
  • John Hunter Children's Hospital (AU)
  • Children's Hospital at Westmead (AU)
Corresponding author
Chrisp, Georgina L
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2020-06-02
Volume
93
Issue
2
Pages
97-103
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/cen.14196
OpenAlex
W3016709078
Cited by
7
References
23
Citations by year
2025: 1 · 2023: 3 · 2021: 1 · 2020: 2
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
adrenal insufficiency, congenital adrenal hyperplasia, stress dosing, patient self-management, acute illness, hyperkalemia, hypotension, electrolytes, blood pressure, cortisol, children
MeSH terms
Acute Disease, Adrenal Insufficiency, Adrenal Hyperplasia, Congenital, Blood Pressure, Child, Electrolytes, Humans, Hydrocortisone, Infant, Newborn

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