Stem cell‐derived exosomes: A promising strategy for fracture healing
Open accessAbstract
Objectives: To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. Methods: Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”. Conclusion: Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal mi RNA s seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.
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Pro-osteogenic miRNAs such as miR-196a, miR-27a, and miR-206 are prominent within BM-MSC EVs.
“Additional research emphasizes the prominence of pro-osteogenic miRNAs, such as miR-196a, miR-27a, and miR-206, within BM-MSCs EVs [49,51,52].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [52]
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- Authors
- Hao, Z., Lu, J., Wang, S., Wu, H., Zhang, Y., & Xu, S.
- Affiliations
- Department of Emergency Changhai Hospital Second Military Medical University Shanghai China
- Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing China
- Zhongda Hospital Southeast University (CN)
- ORCID
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 2017-07-25
- Volume
- 50
- Issue
- 5
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- PMC
- PMC6529061
- OpenAlex
- W2736546079
- Cited by
- 106
- References
- 5
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 16 · 2022: 23 · 2021: 8 · 2020: 16 · 2019: 15 · 2018: 9 · 2017: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Proliferation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81601890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- stem cell-derived exosomes, fracture healing, bone regeneration, exosomal microRNAs, bone formation, angiogenesis, cell proliferation and migration, exosome therapy, clinical translation
- MeSH terms
- Animals, Bone Regeneration, Cell Differentiation, Cell Movement, Humans, Osteogenesis, Stem Cells, Fracture Healing, Neovascularization, Physiologic, MicroRNAs, Regenerative Medicine, Cell Proliferation, Exosomes
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