Techniques for increasing the yield of stem cell-derived exosomes: What factors may be involved?

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215 · see citing works

Progress in Exosome Isolation Techniques

Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 1,970 · see citing works

Stem cells: past, present, and future

Zakrzewski, W., Dobrzyński, M., Szymonowicz, M. K., & Rybak, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1165-5 · Cited by 1,886 · see citing works

Concise review: MSC-derived exosomes for cell-free therapy

Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834 · see citing works

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Lobb, R. J., Becker, M., Wen, S., Wong, C. S. F., Wiegmans, A. P., Leimgruber, A., & Möller, A. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27031 · Cited by 1,725 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works

Design of liposomes as drug delivery system for therapeutic applications

Guimarães, D., Cavaco-Paulo, A. M., & Nogueira, E. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120571 · Cited by 1,235 · see citing works

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

Tauro, B. J., Greening, D. W., Mathias, R. A., Ji, H. L., Mathivanan, S., Scott, A. M., & Simpson, R. J. (2012) · Methods · doi:10.1016/j.ymeth.2012.01.002 · Cited by 1,177 · see citing works

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,122 · see citing works

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics

Yang, D., Zhang, W., Zhang, H., Zhang, F., Chen, L., Ma, L., Larcher, L. M., Chen, S., Liu, N., Zhao, Q., et al. (2020) · Theranostics · doi:10.7150/thno.41580 · Cited by 1,048 · see citing works

VESICLES ASSOCIATED WITH CALCIFICATION IN THE MATRIX OF EPIPHYSEAL CARTILAGE

Anderson, H. C. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.41.1.59 · Cited by 1,046 · see citing works

Exosomes: Therapy delivery tools and biomarkers of diseases

Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,038 · see citing works

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2018) · Theranostics · doi:10.7150/thno.29766 · Cited by 914 · see citing works

Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases

Harrell, C. R., Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V. (2019) · Cells · doi:10.3390/cells8121605 · Cited by 795 · see citing works

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Haraszti, R. A., Didiot, M., Sapp, E., Leszyk, J., Shaffer, S. A., Rockwell, H. E., Gao, F., Narain, N. R., DiFiglia, M., Kiebish, M. A., et al. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32570 · Cited by 746 · see citing works

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744 · see citing works

A Protocol for Exosome Isolation and Characterization: Evaluation of Ultracentrifugation, Density-Gradient Separation, and Immunoaffinity Capture Methods

Greening, D. W., Xu, R., Ji, H. L., Tauro, B. J., & Simpson, R. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2550-6_15 · Cited by 723 · see citing works

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

Nordin, J. Z., Lee, Y., Vader, P., Mäger, I., Johansson, H. J., Heusermann, W., Wiklander, O. P. B., Hällbrink, M., Seow, Y., Bultema, J. J., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.01.003 · Cited by 681 · see citing works

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

Ti, D., Hao, H., Tong, C., Liu, J., Dong, L., Zheng, J., Zhao, Y., Liu, H., Fu, X., & Han, W. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0642-6 · Cited by 664 · see citing works

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Contreras-Naranjo, J. C., Wu, H., & Ugaz, V. M. (2017) · Lab on a Chip · doi:10.1039/c7lc00592j · Cited by 650 · see citing works

Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J. (2018) · Advanced Science · doi:10.1002/advs.201700611 · Cited by 625 · see citing works

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040218 · Cited by 605 · see citing works

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

Gámez‐Valero, A., Tortajada, M., Carreras‐Planella, L., Franquesa, M., Beyer, K., & Borràs, F. E. (2016) · Scientific Reports · doi:10.1038/srep33641 · Cited by 601 · see citing works

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery

Zhou, H., Yuen, P. S. T., Pisitkun, T., Gonzales, P. A., Yasuda, H., Dear, J. W., Gross, P., Knepper, M. A., & Star, R. A. (2006) · Kidney International · doi:10.1038/sj.ki.5000273 · Cited by 586 · see citing works

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Liu, W., Rong, Y., Wang, J., Zhou, Z., Ge, X., Ji, C., Jiang, D., Gong, F., Li, L., Chen, J., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1726-7 · Cited by 583 · see citing works

Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

Haraszti, R. A., Miller, R., Stoppato, M., Sere, Y. Y., Coles, A., Didiot, M.-C., Wollacott, R., Sapp, E., Dubuke, M. L., Li, X., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.09.015 · Cited by 567 · see citing works

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555 · see citing works

Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction

Zhu, L., Tian, T., Wang, J., He, J., Chen, T., Pan, M., Li, X., Zhang, H., Qiu, X., Li, C., et al. (2018) · Theranostics · doi:10.7150/thno.28021 · Cited by 549 · see citing works

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

Busatto, S., Vilanilam, G. K., Ticer, T. D., Lin, W., Dickson, D. W., Shapiro, S. A., Bergese, P., & Wolfram, J. (2018) · Cells · doi:10.3390/cells7120273 · Cited by 538 · see citing works

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

Zarovni, N., Corrado, A., Guazzi, P., Zocco, D., Lari, E., Radano, G., Muhhina, J., Fondelli, C., Gavrilova, J., & Chiesi, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.05.028 · Cited by 535 · see citing works

Acoustic Purification of Extracellular Microvesicles

Lee, K., Shao, H., Weissleder, R., & Lee, H. (2015) · ACS Nano · doi:10.1021/nn506538f · Cited by 535 · see citing works

Exosome mimetics: a novel class of drug delivery systems

Schiffelers, R. M., Kooijmans, S. A. A., Vader, P., van Dommelen, & van Solinge, W. W. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29661 · Cited by 517 · see citing works

Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration

Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511 · see citing works

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola‐Adefeso, O., & Schiffelers, R. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.049 · Cited by 486 · see citing works

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

Zhang, H., & Lyden, D. C. (2019) · Nature Protocols · doi:10.1038/s41596-019-0126-x · Cited by 482 · see citing works

Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., & Sun, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b02277 · Cited by 477 · see citing works

miRNA in Plasma Exosome is Stable under Different Storage Conditions

Ge, Q., Zhou, Y., Lu, J., Bai, Y., Xie, X., & Lu, Z. (2014) · Molecules · doi:10.3390/molecules19021568 · Cited by 475 · see citing works

Exosomes from adipose‐derived stem cells and application to skin wound healing

An, Y., Lin, S., Tan, X.-J., Zhu, S., Nie, F., Zhen, Y., Gu, L., Zhang, C., Wang, B., Wei, W., et al. (2021) · Cell Proliferation · doi:10.1111/cpr.12993 · Cited by 473 · see citing works

Mesenchymal stem cell-derived exosomes for clinical use

Mendt, M. C., Rezvani, K., & Shpall, E. J. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0616-z · Cited by 472 · see citing works

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

Dreux, M., Garaigorta, U., Boyd, B. S., Décembre, É., Chung, J., Whitten-Bauer, C., Wieland, S. F., & Chisari, F. V. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.010 · Cited by 471 · see citing works

Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD

Kuriyan, A. E., Albini, T. A., Townsend, J. H., Rodriguez, M., Pandya, H. K., Leonard, R. E., Parrott, M. B., Rosenfeld, P. J., Flynn, H. W., & Goldberg, J. L. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1609583 · Cited by 465 · see citing works

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

Piffoux, M., Silva, A., Wilhelm, C., Gazeau, F., & Tareste, D. C. (2018) · ACS Nano · doi:10.1021/acsnano.8b02053 · Cited by 463 · see citing works

Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications

Jeyaram, A., & Jay, S. M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0160-y · Cited by 461 · see citing works

Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum

Tang, Y., Huang, Y., Zheng, L., Qin, S., Xu, X.-P., An, T., Xu, Y., Wu, Y.-S., Hu, X., Ping, B., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3080 · Cited by 455 · see citing works

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

Ferguson, S. W., & Nguyen, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.037 · Cited by 419 · see citing works

Design strategies and application progress of therapeutic exosomes

Liu, C., & Su, C. (2019) · Theranostics · doi:10.7150/thno.30853 · Cited by 417 · see citing works

Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, I. L., Corteling, R. L., Bracewell, D. G., & Wall, I. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.006 · Cited by 414 · see citing works

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

Sarker, S., Scholz‐Romero, K., Perez, A., Illanes, S. E., Mitchell, M. D., Rice, G. E., & Salomón, C. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-204 · Cited by 411 · see citing works

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

Li, S.-P., Lin, Z., Jiang, X., & Yu, X. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.178 · Cited by 395 · see citing works

Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

Qu, Y., Zhang, Q., Cai, X., Li, F., Ma, Z., Xu, M., & Lu, L. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13170 · Cited by 391 · see citing works

Strategies for Isolation of ExosomesPreprint

Zeringer, E., Barta, T. J., Li, M., & Vlassov, A. V. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top074476 · Cited by 383 · see citing works

Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis

Chen, C., Rao, S., Ren, L., Hu, X., Tan, Y., Hu, Y., Luo, J., Liu, Y.-W., Yin, H., Huang, J., et al. (2018) · Theranostics · doi:10.7150/thno.22958 · Cited by 380 · see citing works

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents

Börger, V., Bremer, M., Ferrer-Tur, R., Gockeln, L., Stambouli, O., Becic, A., & Giebel, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071450 · Cited by 375 · see citing works

Manufacturing of primed mesenchymal stromal cells for therapy

Yin, J. Q., Zhu, J., & Ankrum, J. A. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0325-8 · Cited by 345 · see citing works

Engineered Exosomes as Vehicles for Biologically Active Proteins

Sterzenbach, U., Putz, U., Low, L., Silke, J., Tan, S., & Howitt, J. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.030 · Cited by 341 · see citing works

Comparison of serum exosome isolation methods for microRNA profiling

Rekker, K., Saare, M., Roost, A. M., Kubo, A., Zarovni, N., Chiesi, A., Salumets, A., & Peters, M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.10.020 · Cited by 327 · see citing works

Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo

Zhang, D., Lee, H., Zhu, Z., Minhas, J., & Jin, Y. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00423.2016 · Cited by 321 · see citing works

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Maroto, R., Zhao, Y., Jamaluddin, M., Popov, V. L., Wang, H., Kalubowilage, M., Zhang, Y., Luisi, J., Sun, H., Culbertson, C. T., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1359478 · Cited by 310 · see citing works

Charge-based precipitation of extracellular vesicles

Deregibus, M. C., Figliolini, F., D’Antico, S., Manzini, P. M., Pasquino, C., Lena, M. D., Tetta, C., Brizzi, M. F., & Camussi, G. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2759 · Cited by 302 · see citing works

Preservation of exosomes at room temperature using lyophilization

Charoenviriyakul, C., Takahashi, Y., Nishikawa, M., & Takakura, Y. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.10.032 · Cited by 290 · see citing works

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

Charoenviriyakul, C., Takahashi, Y., Morishita, M., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.009 · Cited by 280 · see citing works

Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles

Zhai, M., Zhu, Y., Yang, M., & Mao, C. (2020) · Advanced Science · doi:10.1002/advs.202001334 · Cited by 277 · see citing works

Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures

Zonneveld, M. I., Brisson, A. R., van Herwijnen, M. J. C., Tan, S., van de Lest, C. H. A., Redegeld, F. A., Garssen, J., Wauben, M. H. M., & Hoen, E. N. M. N. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24215 · Cited by 274 · see citing works

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

Mianehsaz, E., Mirzaei, H. R., Mahjoubin-Tehran, M., Rezaee, A., Sahebnasagh, R., Pourhanifeh, M. H., Mirzaei, H., & Hamblin, M. R. (2019) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-019-1445-0 · Cited by 274 · see citing works

Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

Furman, N. E. T., Lupu-Haber, Y., Bronshtein, T., Kaneti, L., Letko-Khait, N., Weinstein, E., Baruch, L., & Machluf, M. (2013) · Nano Letters · doi:10.1021/nl401376w · Cited by 272 · see citing works

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

Strauss, K., Goebel, C., Runz, H., Möbius, W., Weiss, S., Feußner, I., Simons, M., & Schneider, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134775 · Cited by 270 · see citing works

Benchtop isolation and characterization of functional exosomes by sequential filtration.

Heinemann, M. L., Ilmer, M., Silva, L. P., Hawke, D., Recio, A., Vorontsova, M., Alt, E., & Vykoukal, J. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.026 · Cited by 266 · see citing works

Stem Cell-Derived Extracellular Vesicles and Immune-Modulation

Burrello, J., Monticone, S., Gai, C., Gomez, Y., Kholia, S., & Camussi, G. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00083 · Cited by 266 · see citing works

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Tang, J., Shen, D., Caranasos, T. G., Wang, Z., Vandergriff, A. C., Allen, T. A., Hensley, M. T., Dinh, P., Cores, J., Li, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms13724 · Cited by 263 · see citing works

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

Jarmalavičiūtė, A., Tunaitis, V., Pivoraitė, U., Venalis, A., & Pivoriūnas, A. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.07.013 · Cited by 260 · see citing works

Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer

Du, W., Zhang, K., Zhang, S., Wang, R., Nie, Y., Tao, H., Han, Z., Liang, L., Wang, D., Liu, J., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.030 · Cited by 250 · see citing works

Large-scale generation of cell-derived nanovesicles

Jo, W., Kim, J., Yoon, J., Jeong, D., Cho, S., Jeong, H., Yoon, Y. J., Kim, S., Gho, Y. S., & Park, J. (2014) · Nanoscale · doi:10.1039/c4nr02391a · Cited by 235 · see citing works

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

Mehryab, F., Rabbani, S., Shahhosseini, S., Shekari, F., Fatahi, Y., Baharvand, H., & Haeri, A. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.036 · Cited by 216 · see citing works

Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth

Lopez‐Verrilli, M. A., Caviedes, A., Cabrera, A. J. H., Sandoval, S., Wyneken, Ú., & Khoury, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.061 · Cited by 208 · see citing works

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Luo, L., Tang, J., Nishi, K., Chen, Y., Dinh, P., Cores, J., Kudo, T., Zhang, J., Li, T., & Cheng, K. (2017) · Circulation Research · doi:10.1161/circresaha.116.310374 · Cited by 208 · see citing works

Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes

Ueda, K., Ishikawa, N., Tatsuguchi, A., Saichi, N., Fujii, R., & Nakagawa, H. (2014) · Scientific Reports · doi:10.1038/srep06232 · Cited by 205 · see citing works

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

Goh, W. J., Zou, S., Ong, W., Torta, F. T., Alexandra, A. F., Schiffelers, R. M., Storm, G., Wang, J., Czarny, B., & Pastorin, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-14725-x · Cited by 202 · see citing works

Quantification of human urinary exosomes by nanoparticle tracking analysis

Oosthuyzen, W., Sime, N. E. L., Ivy, J. R., Turtle, E. J., Street, J. M., Pound, J. D., Bath, L., Webb, D. J., Gregory, C. D., Bailey, M. A., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264069 · Cited by 197 · see citing works

Proteomic Analysis of Exosomes from Human Neural Stem Cells by Flow Field-Flow Fractionation and Nanoflow Liquid Chromatography−Tandem Mass Spectrometry

Kang, D., Oh, S., Ahn, S., Lee, B.-H., & Moon, M. H. (2008) · Journal of Proteome Research · doi:10.1021/pr800225z · Cited by 195 · see citing works

Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes

Lee, B., Kang, I., & Yu, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040711 · Cited by 193 · see citing works

Serum‐free culture alters the quantity and protein composition of neuroblastoma‐derived extracellular vesicles

Li, J., Lee, Y., Johansson, H. J., Mäger, I., Vader, P., Nordin, J. Z., Wiklander, O. P. B., Lehtiö, J., Wood, M. J. A., & Andaloussi, S. E. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26883 · Cited by 185 · see citing works

Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes

Wang, J., Bonacquisti, E. E., Brown, A., & Nguyen, J. (2020) · Cells · doi:10.3390/cells9030660 · Cited by 183 · see citing works

Large-scale production of stem cells utilizing microcarriers: A biomaterials engineering perspective from academic research to commercialized products

Tavassoli, H., Alhosseini, S. N., Tay, A. K. P., Chan, P. P. Y., Oh, S. K. W., & Warkiani, M. E. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.016 · Cited by 180 · see citing works

Exosome Release Is Regulated by mTORC1

Zou, W., Lai, M., Zhang, Y., Zheng, L., Xing, Z., Li, T., Zou, Z., Song, Q., Zhao, X., Xia, L., et al. (2018) · Advanced Science · doi:10.1002/advs.201801313 · Cited by 177 · see citing works

Exosome-mimetic nanoplatforms for targeted cancer drug delivery

Vázquez-Ríos, A. J., Molina-Crespo, Á., Bouzo, B. L., López‐López, R., Moreno‐Bueno, G., & de la Fuente, M. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0517-8 · Cited by 177 · see citing works

The Presence of Contractile Proteins in Platelet Microparticles Isolated from Human and Animal Platelet‐free Plasma

Crawford, N. (1971) · British Journal of Haematology · doi:10.1111/j.1365-2141.1971.tb03416.x · Cited by 176 · see citing works

Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release

Obata, Y., Kita, S., Koyama, Y., Fukuda, S., Takeda, H., Takahashi, M., Fujishima, Y., Nagao, H., Masuda, S., Tanaka, Y., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99680 · Cited by 176 · see citing works

Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions

Wu, J., Li, Y., Hu, X.-B., Huang, S. Q., & Xiang, D. (2021) · Drug Delivery · doi:10.1080/10717544.2020.1869866 · Cited by 168 · see citing works

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

Jo, W., Jeong, D., Kim, J., Cho, S., Jang, S. C., Han, C., Kang, J. Y., Gho, Y. S., & Park, J. (2014) · Lab on a Chip · doi:10.1039/c3lc50993a · Cited by 167 · see citing works

Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis

Liu, L., Liu, Y., Feng, C., Chang, J., Fu, R., Wu, T., Yu, F., Wang, X., Xia, L., Wu, C., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.007 · Cited by 167 · see citing works

Combining magnetic nanoparticles with cell derived microvesicles for drug loading and targeting

Silva, A., Luciani, N., Gazeau, F., Aubertin, K., Bonneau, S., Chauvierre, C., Letourneur, D., & Wilhelm, C. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.11.009 · Cited by 165 · see citing works

Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells

Kim, M., Yun, H., Park, D. Y., Choi, B. H., & Min, B. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0139-5 · Cited by 163 · see citing works

The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing

Wang, C., Liang, C., Wang, R., Yao, X., Guo, P., Yuan, W., Liu, Y., Song, Y., Li, Z., & Xie, X. (2019) · Biomaterials Science · doi:10.1039/c9bm01207a · Cited by 162 · see citing works

Stimulating Extracellular Vesicles Production from Engineered Tissues by Mechanical Forces

Guo, S., Debbi, L., Zohar, B., Samuel, R., Arzi, R. S., Fried, A. I., Carmon, T., Shevach, D., Redenski, I., Schlachet, I., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04834 · Cited by 153 · see citing works

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

Patel, D. B., Luthers, C. R., Lerman, M. J., Fisher, J. P., & Jay, S. M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.024 · Cited by 152 · see citing works

Bone Marrow Mesenchymal Stem Cell-Derived CD63 + Exosomes Transport Wnt3a Exteriorly and Enhance Dermal Fibroblast Proliferation, Migration, and Angiogenesis In Vitro

McBride, J. D., Rodriguez-Menocal, L., Guzman, W., Candanedo, A., García-Contreras, M., & Badiavas, E. V. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0087 · Cited by 141 · see citing works

DNA in serum extracellular vesicles is stable under different storage conditions

Yang, J., Chen, K., Wang, Z., Wang, Y., Liu, J., Lin, L., Shao, Y., Gao, L., Yin, H., Cui, C., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2783-2 · Cited by 139 · see citing works

A Simplified Method to Recover Urinary Vesicles for Clinical Applications and Sample Banking

Musante, L., Tataruch, D., Gu, D., Benito‐Martín, A., Calzaferri, G., Aherne, S. T., & Holthöfer, H. (2014) · Scientific Reports · doi:10.1038/srep07532 · Cited by 138 · see citing works

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

Yoon, J., Jo, W., Jeong, D., Kim, J., Jeong, H., & Park, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.028 · Cited by 133 · see citing works

Role of stem cell derived exosomes in tumor biology

Sharma, A. (2017) · International Journal of Cancer · doi:10.1002/ijc.31089 · Cited by 131 · see citing works

High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism

Ambattu, L. A., Ramesan, S., Dekiwadia, C. D., Hanssen, E. G., Li, H., & Yeo, L. Y. (2020) · Communications Biology · doi:10.1038/s42003-020-01277-6 · Cited by 128 · see citing works

Purification Protocols for Extracellular Vesicles

Lane, R. E., Korbie, D. J., Trau, M., & Hill, M. M. C. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7253-1_10 · Cited by 118 · see citing works

Highly efficient exosome purification from human plasma by tangential flow filtration based microfluidic chip

Han, Z., Peng, C., Yi, J., Zhang, D., Xiang, X., Peng, X., Su, B., Liu, B., Shen, Y., & Qiao, L. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129563 · Cited by 114 · see citing works

Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells

Ji, L., Bao, L., Gu, Z., Zhou, Q., Liang, Y., Zheng, Y., Xu, Y., Zhang, X., & Feng, X. (2019) · Immunologic Research · doi:10.1007/s12026-019-09088-6 · Cited by 113 · see citing works

Preservation techniques of stem cells extracellular vesicles: a gate for manufacturing of clinical grade therapeutic extracellular vesicles and long-term clinical trials

Bahr, M. M., Amer, M., Abo‐EL‐Sooud, K., Abdallah, A. N., & El‐Tookhy, O. S. (2020) · International Journal of Veterinary Science and Medicine · doi:10.1080/23144599.2019.1704992 · Cited by 111 · see citing works

Stem cell‐derived exosomes: A promising strategy for fracture healing

Hao, Z., Lu, J., Wang, S., Wu, H., Zhang, Y., & Xu, S. (2017) · Cell Proliferation · doi:10.1111/cpr.12359 · Cited by 106 · see citing works

Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review

Koh, B., Sulaiman, N. S., Fauzi, M. B., Law, J. X., Ng, M. H., Idrus, R. B. H., & Yazid, M. D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00438-8 · Cited by 106 · see citing works

Self-assembly of stem cell membrane-camouflaged nanocomplex for microRNA-mediated repair of myocardial infarction injury

Yao, C., Wu, W., Tang, H., Jia, X., Tang, J., Ruan, X., Li, F., Leong, D. T., Luo, D., & Yang, D. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120256 · Cited by 106 · see citing works

Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Damasceno, P. K. F., de Santana, T. A., Santos, G. C., Orge, I. D., Silva, D. N., Albuquerque, J. F., Golinelli, G., Grisendi, G., Pinelli, M., dos Santos, R. R., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00737 · Cited by 106 · see citing works

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

Haraszti, R. Á., Miller, R., Dubuke, M. L., Rockwell, H. E., Coles, A. H., Sapp, E., Didiot, M.-C., Echeverria, D., Stoppato, M., Sere, Y. Y., et al. (2019) · iScience · doi:10.1016/j.isci.2019.05.029 · Cited by 103 · see citing works

Bioglass enhances the production of exosomes and improves their capability of promoting vascularization

Wu, Z., He, D., & Li, H. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.011 · Cited by 101 · see citing works

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Fernández-Francos, S., Eiró, N., Costa, L. A., Escudero-Cernuda, S., Fernández‐Sánchez, M. L., & Vizoso, F. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073576 · Cited by 98 · see citing works

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

Pusic, K. M., Pusic, A. D., & Kraig, R. P. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0269-4 · Cited by 97 · see citing works

Stem Cell-Derived Exosome in Cardiovascular Diseases: Macro Roles of Micro Particles

Yuan, Y., Du, W., Liu, J., Ma, W., Zhang, L., Du, Z., & Cai, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00547 · Cited by 95 · see citing works

Fully Artificial Exosomes: Towards New Theranostic Biomaterials

García‐Manrique, P., Gutiérrez, G., & Blanco‐López, M. C. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.10.005 · Cited by 88 · see citing works

Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19

Yan, L., Liu, G., & Wu, X. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.03.005 · Cited by 83 · see citing works

Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

Álvarez‐Viejo, M. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i2.100 · Cited by 82 · see citing works

Improvement of stem cell-derived exosome release efficiency by surface-modified nanoparticles

Park, D. J., Yun, W. S., Kim, W. C., Park, J., Lee, S. H., Ha, S., Choi, J. S., Key, J., & Seo, Y. J. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00739-7 · Cited by 82 · see citing works

Effect of formulation design and freeze-drying on properties of fluconazole multilamellar liposomes

El-Nesr, O. H., Yahiya, S. A., & El-Gazayerly, O. N. (2010) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2010.07.003 · Cited by 81 · see citing works

Design and Characterization of Tissue-Specific Extracellular Matrix-Derived Microcarriers

Turner, A. E. B., & Flynn, L. E. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2011.0246 · Cited by 79 · see citing works

Effect of prolonged freezing of semen on exosome recovery and biologic activity

Welch, J. L., Madison, M. N., Margolick, J. B., Galvin, S., Gupta, P., Martı́nez-Maza, O., Dash, C., & Okeoma, C. M. (2017) · Scientific Reports · doi:10.1038/srep45034 · Cited by 75 · see citing works

Isolation of Small Extracellular Vesicles From Human Serum Using a Combination of Ultracentrifugation With Polymer-Based Precipitation

Ryu, K. J., Lee, J. Y., Park, C., Cho, D., & Kim, S. J. (2019) · Annals of Laboratory Medicine · doi:10.3343/alm.2020.40.3.253 · Cited by 75 · see citing works

Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model

Xu, C., Zhao, J., Li, Q., Hou, L., Wang, Y., Li, S., Jiang, F., Zhu, Z., & Tian, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02023-9 · Cited by 74 · see citing works

Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes

Deun, J. V., Roux, Q., Deville, S., Acker, T. V., Rappu, P., Miinalainen, I., Heino, J., Vanhaecke, F., Geest, B. G. D., Wever, O. D., et al. (2020) · Cells · doi:10.3390/cells9081797 · Cited by 71 · see citing works

Physicochemical Characterization of Liposomes That Mimic the Lipid Composition of Exosomes for Effective Intracellular Trafficking

Sakai‐Kato, K., Yoshida, K., Takechi‐Haraya, Y., & Izutsu, K. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c02491 · Cited by 71 · see citing works

Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro

Ruan, X., Ju, C.-W., Shen, Y., Liu, Y., Kim, I., Yu, H., Weintraub, N. L., Wang, X.-L., & Tang, Y. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.19 · Cited by 69 · see citing works

Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids

Zhang, J., Nguyen, L. T. H., Hickey, R. J., Walters, N. A., Wang, X., Kwak, K. J., Lee, L. J., Palmer, A. F., & Reátegui, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-86910-y · Cited by 69 · see citing works

Dispersible and Dissolvable Porous Microcarrier Tablets Enable Efficient Large-Scale Human Mesenchymal Stem Cell Expansion

Yan, X., Zhang, K., Yang, Y., Deng, D., Lyu, C., Xu, H., Liu, W., & Du, Y. (2020) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0039 · Cited by 64 · see citing works

Scaled Isolation of Mesenchymal Stem/Stromal Cell‐Derived Extracellular Vesicles

Börger, V., Staubach, S., Dittrich, R., Stambouli, O., & Giebel, B. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.128 · Cited by 64 · see citing works

Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO‐cryopreserved platelets

Tegegn, T. Z., Paoli, S. H. D., Orečná, M., Elhelu, O. K., Woodle, S. A., Tarandovskiy, I. D., Ovanesov, M. V., & Šimák, J. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.30422 · Cited by 63 · see citing works

Human mesenchymal stem cell responses to hydrostatic pressure and shear stress

Becquart, P., Cruel, M., Hoc, T. P., Sudre, L., Pernelle, K., Bizios, R., Logeart‐Avramoglou, D., Petite, H., & Bensidhoum, M. (2016) · European Cells and Materials · doi:10.22203/ecm.v031a11 · Cited by 60 · see citing works

Extracellular Matrix in the Regulation of Stem Cell Differentiation

Novoseletskaya, E. S., Grigorieva, O., Efimenko, A. Y., & Kalinina, N. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919030052 · Cited by 60 · see citing works

How does temperature play a role in the storage of extracellular vesicles?

Qin, B., Zhāng, Q., Hu, X., Mi, T., Yu, H., Liu, S., Zhang, B., Tang, M., Huang, J., & Xiong, K. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29700 · Cited by 59 · see citing works

Exosome-coated silk fibroin 3D-scaffold for inducing osteogenic differentiation of bone marrow derived mesenchymal stem cells

Kyung Kim, D., Lee, S., Kim, M., Jeong, Y., & Lee, S. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127080 · Cited by 57 · see citing works

Derivation of Cell-Engineered Nanovesicles from Human Induced Pluripotent Stem Cells and Their Protective Effect on the Senescence of Dermal Fibroblasts

Lee, H., Cha, H., & Park, J. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010343 · Cited by 56 · see citing works

Proposed Mechanisms of Targeting COVID-19 by Delivering Mesenchymal Stem Cells and Their Exosomes to Damaged Organs

Jamshidi, E., Babajani, A., Soltani, P., & Niknejad, H. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10109-3 · Cited by 54 · see citing works

Extracellular Vesicles as Drug Delivery Systems - Methods of Production and Potential Therapeutic Applications

Surman, M., Drożdż, A., Stępień, E. Ł., & Przybyło, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190306153318 · Cited by 53 · see citing works

Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product

Massa, M., Croce, S., Campanelli, R., Abbà, C., Lenta, E., Valsecchi, C., & Avanzini, M. A. (2020) · Diagnostics · doi:10.3390/diagnostics10120999 · Cited by 53 · see citing works

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Cardoso, R. M. S., Rodrigues, S. C., Gomes, C. F., Duarte, F. V., Romao, M., Leal, E. C., Freire, P. C., das Neves, R. P., & Simões‐Correia, J. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0376 · Cited by 53 · see citing works

Role of extracellular vesicles in stem cell biology.

Bruno, S., Chiabotto, G., Favaro, E., Deregibus, M., & Camussi, G. (2019) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00129.2019 · Cited by 43 · see citing works

When Less Is More: Specific Capture and Analysis of Tumor Exosomes in Plasma Increases the Sensitivity of Liquid Biopsy for Comprehensive Detection of Multiple Androgen Receptor Phenotypes in Advanced Prostate Cancer Patients

Foroni, C., Zarovni, N., Bianciardi, L., Bernardi, S., Triggiani, L., Zocco, D., Venturella, M., Chiesi, A., Valcamonico, F., & Berruti, A. (2020) · Biomedicines · doi:10.3390/biomedicines8050131 · Cited by 43 · see citing works

A novel micro-emulsion and micelle assembling method to prepare DEC205 monoclonal antibody coupled cationic nanoliposomes for simulating exosomes to target dendritic cells

Li, K., Chang, S., Wang, Z., Zhao, X., & Chen, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.05.068 · Cited by 42 · see citing works

Functional Analysis of Exosomal MicroRNA in Cell–Cell Communication Research

Kosaka, N., Yoshioka, Y., Hagiwara, K., Tominaga, N., & Ochiya, T. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-453-1_1 · Cited by 41 · see citing works

Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis

Peng, K., Liu, Y., Li, Y., Yen, B. L., & Yen, M. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13087 · Cited by 41 · see citing works

The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches

Makris, N., Tsintou, M., Dalamagkas, K., Moore, T. L., Yogesh Rathi, A., Kubicki, M. R., & Rosene, D. L. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.295269 · Cited by 40 · see citing works

Exosome-based therapeutics: Purification using semi-continuous multi-column chromatography

Moleirinho, M. G., Silva, R. J. S., Carrondo, M. J. T., Alves, P. M., & Peixoto, C. (2019) · Separation and Purification Technology · doi:10.1016/j.seppur.2019.04.060 · Cited by 34 · see citing works

Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress

Shin, S., Kim, H., Seo, Y., Kim, C. H., Kim, J. M., Kwon, H., Lee, J., Sung, E., & Lee, B. (2020) · Stem Cells International · doi:10.1155/2020/2560828 · Cited by 33 · see citing works

Evaluation of the Storage Stability of Extracellular Vesicles

Richter, M., Fuhrmann, K., & Fuhrmann, G. (2019) · Journal of Visualized Experiments · doi:10.3791/59584 · Cited by 31 · see citing works

Methods of Analysis of Dendritic Cell-Derived Exosome-Shuttle MicroRNA and Its Horizontal Propagation Between Dendritic Cells

Montecalvo, A., Larregina, A. T., & Morelli, A. E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-453-1_3 · Cited by 30 · see citing works

Improved the biocompatibility of cancellous bone with compound physicochemical decellularization process

Ling, Y., Xu, W., Yang, L., Liang, C., & Xu, B. (2020) · Regenerative Biomaterials · doi:10.1093/rb/rbaa024 · Cited by 29 · see citing works

Stimulation of exosome biogenesis by adiponectin, a circulating factor secreted from adipocytes

Kita, S., & Shimomura, I. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa105 · Cited by 29 · see citing works

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Kornmuller, A., Brown, C. F. C., Yu, C., & Flynn, L. E. (2017) · Journal of Visualized Experiments · doi:10.3791/55436 · Cited by 26 · see citing works

Formation of vesicles-in-a-vesicle with asymmetric lipid components using a pulsed-jet flow method

Kamiya, K., Osaki, T., & Takeuchi, S. (2019) · RSC Advances · doi:10.1039/c9ra04622d · Cited by 26 · see citing works

Gene-modified Exosomes Protect the Brain Against Prolonged Deep Hypothermic Circulatory Arrest

Shi, J., Jiang, X., Gao, S., Zhu, Y., Liu, J., Gu, T., & Shi, E. (2020) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2020.05.075 · Cited by 25 · see citing works

Development of Artificial Plasma Membranes Derived Nanovesicles Suitable for Drugs Encapsulation

Martinelli, C., Gabriele, F., Dini, E., Carriero, F., Bresciani, G., Slivinschi, B., Giudici, M. D., Zanoletti, L., Manai, F., Paolillo, M., et al. (2020) · Cells · doi:10.3390/cells9071626 · Cited by 23 · see citing works

Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis

Ishiy, C. S. R. A., Ormanji, M. S., Maquigussa, E., Ribeiro, R. S., da Silva, J. A. N., & Boim, M. A. (2020) · Stem Cells International · doi:10.1155/2020/8814574 · Cited by 23 · see citing works

Improved Small Extracellular Vesicle Secretion of Rat Adipose‐Derived Stem Cells by Microgrooved Substrates through Upregulation of the ESCRT‐III‐Associated Protein Alix

Ji, Y., Han, W., Fu, X., Li, J., Wu, Q., & Wang, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100492 · Cited by 23 · see citing works

Formation of nano-sized lipid vesicles with asymmetric lipid components using a pulsed-jet flow method

Kamiya, K., Osaki, T., & Takeuchi, S. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128917 · Cited by 21 · see citing works

Multi-Layer Micro-Nanofluidic Device for Isolation and Capture of Extracellular Vesicles Derived From Liposarcoma Cell Conditioned Media

Sundaram, P. M., Casadei, L., Lopez, G., Braggio, D., Balakirsky, G., Pollock, R. E., & Prakash, S. (2020) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2020.3006786 · Cited by 20 · see citing works

The potential diagnostic and therapeutic applications of exosomes in drug-induced liver injury

Zhao, L., Wang, Y., & Zhang, Y. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.11.021 · Cited by 20 · see citing works

Three‐dimensional culture of dental pulp pluripotent‐like stem cells (DPPSCs) enhances Nanog expression and provides a serum‐free condition for exosome isolation

Faruqu, F. N., Zhou, S., Sami, N., Gheidari, F., Han, L., & Al‐Jamal, K. T. (2020) · FASEB BioAdvances · doi:10.1096/fba.2020-00025 · Cited by 19 · see citing works

Dielectrophoretic manipulation of exosomes in a multi-section microfluidic device

Ayala‐Mar, S., Gallo‐Villanueva, R. C., & González‐Valdez, J. (2019) · Materials Today Proceedings · doi:10.1016/j.matpr.2019.03.162 · Cited by 17 · see citing works

Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells

Geßner, A., Koch, B., Klann, K., Fuhrmann, D. C., Farmand, S., Schubert, R., Münch, C., Geiger, H., & Baer, P. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062873 · Cited by 17 · see citing works

Role of Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Cardiac Tissue and Improvement of Cardiac Function: a Narrative Review

(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac111.84468456 · Cited by 11 · see citing works

Understanding exosomes: Part 1—Characterization, quantification and isolation techniques

Miron, R. J., & Zhang, Y. (2023) · Periodontology 2000 · doi:10.1111/prd.12520 · Cited by 96 · see citing works

Production and Utility of Extracellular Vesicles with 3D Culture Methods

Ester, M. C., & Day, R. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020663 · Cited by 67 · see citing works

The CRISPR/Cas9 System Delivered by Extracellular Vesicles

Zhu, X., Gao, M., Yang, Y., Li, W., Bao, J., & Li, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030984 · Cited by 59 · see citing works

Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production

García‐Aponte, O. F., Kahlenberg, S., Kouroupis, D., Egger, D., & Kasper, C. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70057 · Cited by 49 · see citing works

Mechanical stimulation on a microfluidic device to highly enhance small extracellular vesicle secretion of mesenchymal stem cells

Hao, R., Hu, S., Zhang, H., Chen, X., Yu, Z., Ren, J., Guo, H., & Yang, H. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100527 · Cited by 44 · see citing works

Mesenchymal and Neural Stem Cell-Derived Exosomes in Treating Alzheimer’s Disease

Wang, H., Huber, C. C., & Li, X. (2023) · Bioengineering · doi:10.3390/bioengineering10020253 · Cited by 44 · see citing works

Mechanistic insights into periodontal ligament stem cell-derived exosomes in tissue regeneration

Ahmad, P., Estrin, N. E., Farshidfar, N., Zhang, Y., & Miron, R. J. (2025) · Clinical Oral Investigations · doi:10.1007/s00784-025-06422-1 · Cited by 40 · see citing works

MSC-Exos: important active factor of bone regeneration

Ren, S., Lin, Y., Liu, W., Yang, L., & Zhao, M. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1136453 · Cited by 37 · see citing works

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles

Xu, X., Wang, Y., Luo, X., Gao, X., Gu, W., Ma, Y., Xu, L., Yu, M., Liu, X., Liu, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1150971 · Cited by 33 · see citing works

Precision exosome engineering for enhanced wound healing and scar revision

Liu, C., Chen, C., Cheng, K., Gao, A. S., Li, Q., Atala, A., & Zhang, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06578-0 · Cited by 27 · see citing works

Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment

Wu, X., Niu, J., & Shi, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02544-y · Cited by 20 · see citing works

Multi-omics of extracellular vesicles: An integrative representation of functional mediators and perspectives on lung disease study

Liu, Y., Li, Y., & Zeng, T. (2023) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2023.1117271 · Cited by 19 · see citing works

Advances in 3D printing techniques for cartilage regeneration of temporomandibular joint disc and mandibular condyle

Hu, S., Yi, Y., Ye, C., Liu, J., & Wang, J. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.761 · Cited by 19 · see citing works

Application of exosome-derived noncoding RNAs in bone regeneration: Opportunities and challenges

Ren, Y., Ding, S., Jiang, Y., Wen, H. X., & Li, T. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i7.473 · Cited by 18 · see citing works

Stem Cell-Derived Extracellular Vesicles for Cancer Therapy and Tissue Engineering Applications

Lee, C., Lee, M., Na, K., & Hwang, H. S. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00376 · Cited by 18 · see citing works

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow–derived neural crest cells

Meng, C., Hu, J., Yu, Y., Li, X.-L., Sun, X., Wang, L., Wu, X., Zhu, L.-J., Yang, X., He, Q., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390956 · Cited by 16 · see citing works

Breakthrough in large-scale production of iPSCs-derived exosomes to promote clinical applications

Chen, X., Li, K., Chen, J., & Tan, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1257186 · Cited by 15 · see citing works

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

Xu, Y., Cheung, C. Y. M., Liu, L., Cheung, H. P., Tam, K. Y., Ker, D. F. E., Cartmell, S. H., Mao, C., Zhang, Z., & Wang, D. M. (2025) · BMEMat · doi:10.1002/bmm2.70012 · Cited by 13 · see citing works

Engineered exosomal miR140 modulates mitophagy of chondrocytes through targeting CAPN1 to alleviate osteoarthritis

Liu, Y., Huang, K., Zhou, S., Li, S., Si, H., Zeng, Y., Xie, H., & Shen, B. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2843-7 · Cited by 13 · see citing works

Molecular Docking and Intracellular Translocation of Extracellular Vesicles for Efficient Drug Delivery

Matsuzaka, Y., & Yashiro, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112971 · Cited by 8 · see citing works

Extracellular Vesicles as Promising Vectors for CRISPR/Cas9 Delivery: Advantages, Challenges, and Clinical Implications

Siraj, N., Dilfy, S. H., & Abduljaleel, R. H. (2023) · Trends in Pharmaceutical Biotechnology · doi:10.57238/tpb.2023.144271.1002 · Cited by 8 · see citing works

Spheroid-Exosome-Based Bioprinting Technology in Regenerative Medicine

Lee, H.-Y., & Lee, J. W. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15110345 · Cited by 9 · see citing works

Stem cell-derived extracellular vesicles: novel therapeutics for cerebral injury following cardiac arrest and potential mechanisms

Zhang, X., Zhang, W., Chen, Z., Zhu, R., Lin, Y., Wu, C., Xu, J., Zhou, G., & Zhang, M. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01451-5 · Cited by 9 · see citing works

The Transformative Impact of Extracellular Vesicles on the Cosmetics Industry: A Comprehensive Review

Col, V. D., Ribas, F. F., & Araldi, R. P. (2025) · Cosmetics · doi:10.3390/cosmetics12050191 · Cited by 8 · see citing works

Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma

Hu, J., Xie, C. H., Xu, S., Pu, Q., Liu, H., Yang, L., Wang, W., Mao, L., Li, Z., & Chen, W. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286017 · Cited by 7 · see citing works

Extracellular Vesicles Derived From 3D Cultured Antler Stem Cells Serve as a New Drug Vehicle in Osteosarcoma Treatment

Hu, P., Ying, J., Wang, Y., Jiang, T., Pan, Z., Zhao, C., Li, J., & Li, C. (2023) · Cell Transplantation · doi:10.1177/09636897231219830 · Cited by 6 · see citing works

Research on the TSPAN6 regulating the secretion of ADSCs-Exos through syntenin-1 and promoting wound healing

Qiao, Z., Wang, X., Zhao, H., Deng, Y., Zeng, W., Wu, J., & Chen, Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04004-8 · Cited by 6 · see citing works

Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence

Liu, Y., Huang, L., Zeng, Y., Li, M., Xie, H., & Shen, B. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2090-3 · Cited by 5 · see citing works

Apoptosis linked gene-2 interacting protein X as a target to regulate the yield of small extracellular vesicles derived from tissue specific mesenchymal stem cells for translational applications

Sharma, Y., Bhakuni, S., Mathew, C. K., Vaishnav, P. K., Giri, S., & Mohanty, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145092 · Cited by 3 · see citing works

Enhanced exosome biomanufacturing, precision isolation, and advanced engineering: toward mechanistic regulation and biomaterial integration for osteoarthritis therapy

Gao, M., Yin, Q., Zhong, Z., Song, Z., Song, X., Zhao, R., Wen, H. L., He, F., Zhang, M., & Pang, Q. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04710-w · Cited by 3 · see citing works

The Impact of Neurotoxin Proteins Trafficked by Primary Cilia and Extracellular Vesicles in Neurodegenerative Diseases

Danna, R., Kondle, S., Amar, O., Mabourakh, M., Chen, G., Fadol, W. B., & Mohieldin, A. M. (2025) · Biology · doi:10.3390/biology14121787 · Cited by 2 · see citing works

Targeted knockdown of MSC-sEVs biogenesis regulator proteins to elucidate the mechanisms of their production: a step towards translational applications

Sharma, Y., & Mohanty, S. (2025) · Cytotherapy · doi:10.1016/j.jcyt.2025.02.002 · Cited by 2 · see citing works

Efficacy of Stem Cell-derived Extracellular Vesicles in the Treatment of Alzheimer's Disease Model Mice: A Systematic Review and Meta-analysis

Zheng, Q., Wang, S., Wang, T., & Zhang, G. (2025) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x352270250407170235 · Cited by 2 · see citing works

Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant lncRNAs

Ali, S. O., Shahin, N. N., Safar, M. M., & Rizk, S. M. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400242 · Cited by 1 · see citing works

Biorthogonal click-immobilized probiotic membrane vesicles in a dynamic hydrogel for accelerated and scar-minimized wound healing

Zhang, S., Zhou, M., Li, M., Wang, R., Yang, C., Yang, L., Wang, J., Deng, X., Dai, J., & Liu, Q. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103046 · Cited by 1 · see citing works

Exploring the Biogenesis of Extracellular Vesicles in Cancer and Stem Cell Biology: Diverge Origins, Common ThreadsPreprint

Sharma, Y., & Mohanty, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4641558/v1

Comparative Assessment of sEV Biogenesis Regulator Proteins in MSCs and HeLa Cells for Elucidating Novel Therapeutic StrategiesPreprint

Sharma, Y., & Mohanty, S. (2024) · Research Square · doi:10.21203/rs.3.rs-5261448/v1

Quality control, minimizing heterogeneity and enhancing yield in exosome isolation and production

Mokati, A. S., Uppal, L., Naemoddin, P. M., & Jindal, A. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00006-4

Human umbilical cord mesenchymal stromal cell-derived exosomes from MSCs pretreated with inflammatory factors attenuate renal injury of diabetic mice by regulating macrophage polarization

Li, C., Tian, Y., Yuan, Y., Du, Y., Xu, Z., & Li, L. (2026) · Clinical Science · doi:10.1042/cs20258827

Food-derived extracellular vesicles as delivery platforms for medicine–food homology components in metabolic syndrome

Wang, J., Sun, B., Tong, L., & Ai, N. (2026) · Food Research International · doi:10.1016/j.foodres.2026.120361

Stem-cell‑derived exosomes: a comprehensive review from basic biology to clinical translation challenges

Hasan, M. T., Hossain, M. B., Rahman, M. M., Hasan, M. S., Hasan, M., & Mithu, M. M. (2024) · New medicine. · doi:10.1097/nm9.0000000000000004 · Cited by 1 · see citing works

Therapeutic Strategies and Enhanced Production of Stem Cell-Derived Exosomes for Tissue Regeneration

Kim, H., Kim, D., Kim, W., Lee, S., Gwon, Y., Park, S., & Kim, J. (2023) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2022.0118 · Cited by 17 · see citing works

STEM CELL-DERIVED EXOSOMES: BIOGENESIS, CHARACTERIZATION, ISOLATION AND PRECONDITIONING

Mittal, P., Shevchuk, O. O., Dovgalyuk, А. І., Ivankiv, Y. I., & Korda, М. М. (2026) · Medical and Clinical Chemistry · doi:10.11603/mcch.2410-681x.2026.i3.16728

Stem Cell Based Exosomes: Are They Effective in Disease or Health?

Kucukguven, M. B., & Çelebi‐Saltik, B. (2021) · Advances in experimental medicine and biology · doi:10.1007/5584_2021_630 · Cited by 1 · see citing works

Challenges and strategies: Scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy

Pan, W., Chen, H., Wang, A., Wang, F., & Zhang, X. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121524 · Cited by 68 · see citing works