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Cited by 15Renal Transplantation Outcomes and TreatmentsDermatology and Skin DiseasesDrug-Induced Adverse Reactions

The DOI matches its Crossref record.

Mucocutaneous disorders in renal transplant recipients receiving sirolimus‐based immunosuppressive therapy: a prospective, case–control study

Özcan, Deren, Seçkin, Deniz, Ada, Simin, Haberal, Mehmet·2013·Clinical Transplantation
DOI 10.1111/ctr.12215
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Abstract

Background Sirolimus (SRL) has some dermatologic complications including acneiform eruptions, edema, aphthous ulceration, and onychopathy. However, controlled studies reporting the prevalence and clinical characteristics of mucocutaneous disorders are scarce. Objective To investigate the prevalence and clinical spectrum of mucocutaneous disorders in renal transplant recipients (RTRs) receiving SRL and to compare the findings with those in RTRs not receiving SRL. Methods Fifty RTRs (35 men, 15 women; mean age, 34.6 ± 11.6 yr) receiving SRL, 50 RTRs (36 men, 14 women; mean age, 34.4 ± 11.3 yr) not on SRL were screened for mucocutaneous disorders. Results In RTRs receiving SRL, skin infection (78%) was the most common dermatologic disorder followed by facial hyperpigmentation (50%) and acneiform eruption (46%). Herpes simplex virus infections (14%) and seborrheic dermatitis (38%) were significantly more common in RTRs on SRL (p 0.05). Limitations This study had a small sample size. The investigator was not blinded to immunosuppressive treatment protocols. Conclusion Renal transplant recipients receiving SRL are more likely to develop seborrheic dermatitis and herpes simplex virus infections than those not taking SRL. Whereas, they are not more prone to edema, aphthous ulceration, acne, or longitudinal nail ridging.

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Metadata

Authors
Özcan, D., Seçkin, D., Ada, S., & Haberal, M.
Affiliations
Başkent University (TR)
Corresponding author
Özcan, Deren
ORCID
Venue
Clinical Transplantation
Publisher
Wiley
Published
2013-08-31
Volume
27
Issue
5
Pages
742-748
ISSN
  • 0902-0063 (ISSN-L)
  • 1399-0012
DOI
10.1111/ctr.12215
OpenAlex
W2089921447
Cited by
15
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Transplantation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords
rapamycin, kidney transplant recipients, mucocutaneous disease, seborrheic dermatitis, herpes simplex, skin infections, facial hyperpigmentation, acneiform eruption, edema, aphthous ulceration, immunosuppressive therapy adverse effects
MeSH terms
Adolescent, Adult, Female, Follow-Up Studies, Graft Rejection, Humans, Immunosuppressive Agents, Male, Middle Aged, Mucous Membrane, Prognosis, Prospective Studies, Risk Factors, Skin Diseases, Infectious, Case-Control Studies, Kidney Transplantation, Sirolimus, Young Adult

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CoChat. (2026). Citation check: Mucocutaneous disorders in renal transplant recipients receiving sirolimus‐based immunosuppressive therapy: a prospective, case–control study. https://app.cochat.ai/papers/10.1111/ctr.12215
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Özcan, D., Seçkin, D., Ada, S., & Haberal, M. (2013). Mucocutaneous disorders in renal transplant recipients receiving sirolimus‐based immunosuppressive therapy: a prospective, case–control study. Clinical Transplantation. https://doi.org/10.1111/ctr.12215

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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