Delirium after lung transplantation: Association with recipient characteristics, hospital resource utilization, and mortality
Open accessAbstract
BACKGROUND: Delirium is associated with increased morbidity and mortality. The factors associated with post-lung transplant delirium and its impact on outcomes are under characterized. METHODS: The medical records of 163 consecutive adult lung transplant recipients were reviewed for delirium within 5 days (early-onset) and 30 hospital days (ever-onset) post-transplantation. A multivariable logistic regression model assessed factors associated with delirium. Multivariable negative binomial regression and Cox proportional hazards models assessed the association of delirium with ventilator duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, and one-year mortality. RESULTS: Thirty-six percent of patients developed early-onset, and 44% developed ever-onset delirium. Obesity (OR 6.35, 95% CI 1.61-24.98) and bolused benzodiazepines within the first postoperative day (OR 2.28, 95% CI 1.07-4.89) were associated with early-onset delirium. Early-onset delirium was associated with longer adjusted mechanical ventilation duration (P=.001), ICU LOS (P<.001), and hospital LOS (P=.005). Ever-onset delirium was associated with longer ICU (P<.001) and hospital LOS (P<.001). After adjusting for clinical variables, delirium was not significantly associated with one-year mortality (early-onset HR 1.65, 95% CI 0.67-4.03; ever-onset HR 1.70, 95% CI 0.63-4.55). CONCLUSIONS: Delirium is common after lung transplant surgery and associated with increased hospital resources.
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Dementia has been associated with adverse postoperative outcomes.
“Dementia has been associated with adverse postoperative outcomes.(90–93)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [91]
The Background (page unavailable) says premorbid cognitive dysfunction is a risk factor for delirium. The Abstract Results (page unavailable) link postoperative delirium—not dementia—to longer ventilation and hospital stays. A search for dementia and postoperative outcomes found no passage addressing the claimed association. (LLM, conf=0.74)
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- Authors
- Sher, Y., Mooney, J., Dhillon, G., Lee, R., & Maldonado, J. R.
- Affiliations
- Stanford Medicine (US)
- Stanford Health Care (US)
- Corresponding author
- Sher, Yelizaveta
- Venue
- Clinical Transplantation
- Publisher
- Wiley
- Published
- 2017-04-11
- Volume
- 31
- Issue
- 5
- Pages
- e12966
- ISSN
- 0902-0063 (ISSN-L)
- PMC
- PMC5509889
- OpenAlex
- W2596021388
- Semantic Scholar
- 907be8f4e728072beaa5024e89c5584ed58f9c65
- Cited by
- 41
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 1 · 2018: 5
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Clinical Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- KL2 Mentored Career Development Award of the Stanford Clinical (KL2 TR 001083)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- delirium, lung transplantation, postoperative delirium, obesity, benzodiazepines, mechanical ventilation duration, ICU length of stay, length of hospital stay, mortality, hospital resource utilization
- MeSH terms
- Delirium, Female, Follow-Up Studies, Health Resources, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Postoperative Complications, Prognosis, Respiration, Artificial, Retrospective Studies, Risk Factors, Time Factors, Lung Transplantation, Hospital Mortality, Transplant Recipients
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