The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Prevalence of cognitive impairment in liver transplant recipients
Open accessAbstract
Liver transplant (LT) recipients have a high burden of cognitive impairment risk factors identified in other populations, yet little work has explored cognition in the United States LT population. We characterized prevalence of cognitive impairment (CI) in LT recipients pre‐LT and ≥3 months post‐LT. Adult LT recipients with cirrhosis but without active pre‐LT hepatic encephalopathy (HE) were screened for CI using the Montreal Cognitive Assessment (MoCA) for CI (MoCA <24) both pre‐LT and ≥3 months post‐LT. The association between cognitive performance and recipient characteristics was assessed using logistic regression. Of 107 LT recipients, 36% had pre‐LT CI and 27% had post‐LT CI [median (Q1–Q3) MoCA 26 (23–28)]. Each 1‐point increase in pre‐LT MoCA was associated with 26% lower odds of post‐LT cognitive impairment (aOR .74, 95% CI .63–.87, p < .001), after adjusting for recipient age, history of HE, and time since LT. In this study of cirrhosis recipients without active pre‐LT HE, cognitive impairment was prevalent before LT and remained prevalent ≥3 months after LT (27%), long after effects of portal hypertension on cognition would be expected to have resolved. Our data expose an urgent need for more comprehensive neurologic examination of LT recipients to better identify, characterize, and address predictors of post‐LT cognitive impairment.
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In Berry et al, each point increase in pretransplant MoCA was associated with 26% lower odds of post-liver transplantation cognitive impairment (adjusted OR 0.74, 95% CI 0.63-0.87, p<0.001), after adjusting for recipient age, history of HE, and time since liver transplantation.
“Berry et al14 found that each point increase in the pretransplant Montreal Cognitive Assessment was associated with 26% lower odds of post-liver transplantation cognitive impairment (adjusted OR: 0.74, 95% CI: 0.63–0.87, p<0.001), after adjusting for recipient age, history of HE, and time since liver transplantation.”
From Management of depression/anxiety in patients with chronic liver disease (2024) · cites this paper as [14]
The Montreal Cognitive Assessment can help determine the prevalence of cognitive impairment in patients listed for liver transplantation.
“The Montreal Cognitive Assessment, can also help to determine the prevalence of cognitive impairment in patients listed for liver transplantation.14”
From Management of depression/anxiety in patients with chronic liver disease (2024) · cites this paper as [14]
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Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology
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Self-citationLongterm calcineurin inhibitor therapy and brain function in patients after liver transplantation
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Postoperative cognitive dysfunction after liver transplantation
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Cognitive Impairment and Physical Frailty in Patients With Cirrhosis
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Self-citationHepatic Encephalopathy Is Reversible in the Long Term After Liver Transplantation
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Cognitive Function in Liver Transplantation
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Self-citationCognitive Function in Liver Transplant Recipients Who Survived More Than 6 Months
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Cognitive Dysfunction in Liver Disease and Its Implications for Transplant Candidates
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Management of depression/anxiety in patients with chronic liver disease
Garcia-Altieri, M., Carrera-Mejias, K., & Hernaez, R. (2024) · Clinical Liver Disease · doi:10.1097/cld.0000000000000179 · Cited by 11
Metadata
- Authors
- Berry, K., Ruck, J. M., Barry, F., Shui, A. M., Cortella, A., Kent, D., Seetharaman, S., Wong, R., VandeVrede, L., & Lai, J. C.
- Affiliations
- University of California, San Francisco (US)
- Johns Hopkins University (US)
- Corresponding author
- Lai, Jennifer C.
- ORCID
- Venue
- Clinical Transplantation
- Publisher
- Wiley
- Published
- 2023-12-19
- Volume
- 38
- Issue
- 1
- Pages
- e15229-e15229
- ISSN
- 0902-0063 (ISSN-L)
- 1399-0012
- PMC
- PMC10842727
- OpenAlex
- W4389981755
- Cited by
- 6
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Transplantation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- cognitive impairment, liver transplantation, liver cirrhosis, hepatic encephalopathy, Montreal Cognitive Assessment, prevalence, portal hypertension, neurocognitive screening
- MeSH terms
- Adult, Cognition, Humans, Liver Cirrhosis, United States, Prevalence, Liver Transplantation, Cognitive Dysfunction
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