The diagnosis of early-stage mycosis fungoides: Views held by experts and non-experts in cutaneous lymphoma
Open accessAbstract
BACKGROUND AND OBJECTIVES: Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas (CL). There is a documented delay in the diagnosis of early-stage MF. However, its timely diagnosis is paramount to avoid potentially harmful therapies and undue patient distress. The aim of this study was to examine and compare the views held by both specialists and non-specialists in CL regarding the diagnosis of early-stage MF, to identify clinical needs. METHODS: Two distinct questionnaires were distributed to physicians, who either have a potential or no special interest in CL (non-specialists), or who have a special interest in CL (specialists) and who were identified by participation in the PROCLIPI (PROspective Cutaneous Lymphoma International Prognostic Index) study. RESULTS: Survey results were received from 382 participants, 86 specialists, and 296 non-specialists. In total, 82% of respondents held the view that the diagnosis of early-stage MF is delayed. The frequent misclassification of MF as a benign inflammatory dermatosis was identified as the most important contributing factor. CONCLUSIONS: Non-specialists assume that a delayed diagnosis impairs therapeutic efficacy and prognosis in MF, while specialists primarily suspect negative effects on patients' health-related quality of life. Our study reveals an unmet need to promote education and increase awareness among dermatologists regarding the impact of early-stage MF on patient management.
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Recent international survey data from Beatty et al. revealed that the vast majority of experts and general practitioners acknowledge that the diagnosis of eMF is structurally delayed, primarily due to clinical and histological misclassification as BIDs.
“Recent international survey data from Beatty et al. revealed that the vast majority of experts and general practitioners acknowledge that the diagnosis of eMF is structurally delayed, primarily due to clinical and histological misclassification as BIDs 16 .”
From Histological triage of early-stage mycosis fungoides using a weakly supervised deep learning-based model: a multicentre, external validation, and clinical utility study (2026) · cites this paper as [16]
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- Authors
- Beatty, P., Molloy, K., Porkert, S., Foley, M. P., Tobin, A., Trautinger, F., Scarisbrick, J., & Jonak, C.
- Affiliations
- Trinity College Dublin (IE)
- Medical University of Vienna (AT)
- Universitätsklinikum St. Pölten (AT)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Corresponding author
- Jonak, Constanze
- ORCID
- Venue
- JDDG: Journal der Deutschen Dermatologischen Gesellschaft
- Publisher
- Wiley
- Published
- 2025-06-29
- Volume
- 23
- Issue
- 9
- Pages
- 1094-1102
- ISSN
- 1610-0379 (ISSN-L)
- 1610-0387
- PMC
- PMC12435154
- OpenAlex
- W4411840350
- Cited by
- 3
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2
- FWCI
- 2.87
- Type
- journal article
- Language
- de
- Open access
- hybrid
- doi.org
- Licence
- Locations
- JDDG Journal der Deutschen Dermatologischen Gesellschaft (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- mycosis fungoides, cutaneous T-cell lymphoma, early-stage diagnosis, delayed diagnosis, physician perceptions, health-related quality of life
- MeSH terms
- Adult, Attitude of Health Personnel, Female, Germany, Humans, Male, Middle Aged, Mycosis Fungoides, Surveys and Questionnaires, Skin Neoplasms, Delayed Diagnosis
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