The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Worsening of diabetic retinopathy with rapid improvement in systemic glucose control: A review
Open accessAbstract
Worsening of diabetic retinopathy (DR) is associated with the initiation of effective treatment of glycaemia in some patients with diabetes. It has been associated with risk factors such as poor blood‐glucose control and hypertension, and it manifests prior to the long‐term benefits of optimizing glycaemic control. The majority of evidence supports an association of large and rapid reductions in blood‐glucose levels with early worsening of DR. Despite a general awareness of early worsening within the diabetes community, mechanisms to explain the phenomenon remain speculative. We provide an overview of early worsening of DR and its pathophysiology based on current data. We describe the phenomenon in various settings, including in patients receiving insulin‐ or non‐insulin‐based treatments, in those undergoing bariatric surgery, and in pregnant women. We discuss various mechanisms and theories that have been suggested to explain this paradoxical phenomenon, and we summarize the implications of these in clinical practice.
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Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
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Cited by
Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy
Yang, J., & Liu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.816400 · Cited by 281
Bethel, M. A., Diaz, R., Castellana, N., Bhattacharya, I., Gerstein, H. C., & Lakshmanan, M. C. (2021) · Diabetes Care · doi:10.2337/dc20-1815 · Cited by 151
Lakhani, M., Kwan, A. T. H., Mihalache, A., Popovic, M. M., Nanji, K., Xie, J. S., Feo, A., Rabinovitch, D., Shor, R., Sadda, S., et al. (2025) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2025.05.007 · Cited by 70
Bays, H. E., Fitch, A., Christensen, S., Burridge, K., & Tondt, J. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2022.100018 · Cited by 68
Yoshida, Y., Joshi, P., Barri, S., Wang, J., Corder, A. L., O'Connell, S. S., & Fonseca, V. A. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108255 · Cited by 65
Metadata
- Authors
- Bain, S. C., Klufas, M. A., Ho, A., & Matthews, D. R.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2018-10-15
- Volume
- 21
- Issue
- 3
- Pages
- 454-466
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2891332575
- Cited by
- 299
- References
- 73
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bain, S. C., Klufas, M. A., Ho, A., & Matthews, D. R. (2019). Worsening of diabetic retinopathy with rapid improvement in systemic glucose control: A review. Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.13538
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
