Postprandial Hypoglycaemia after Roux-en-Y Gastric Bypass and the Effects of Acarbose, Sitagliptin, Verapamil, Liraglutide and Pasireotide
Abstract
Aim To investigate the effects of acarbose, sitagliptin, verapamil, liraglutide and pasireotide on post-bariatric hypoglycaemia (PBH) after Roux-en-Y gastric bypass. Materials and methods In a randomized crossover study, 11 women who had undergone Roux-en-Y gastric bypass and had documented hypoglycaemia were each evaluated during a baseline period without treatment and during five treatment periods with the following interventions: acarbose 50 mg for 1 week, sitagliptin 100 mg for 1 week, verapamil 120 mg for 1 week, liraglutide 1.2 mg for 3 weeks and pasireotide 300 μg as a single dose. Treatment effects were evaluated by a mixed-meal tolerance test (MMTT) and, for all treatment periods except pasireotide, by 6 days of continuous glucose monitoring (CGM). Results Treatment with acarbose and treatment with pasireotide both significantly lifted nadir glucose levels (mean ± SEM 3.9 ± 0.2 and 7.9 ± 0.4 vs 3.4 ± 0.2; P Conclusions In an experimental setting, treatment with acarbose and pasireotide reduced PBH. Acarbose appears to have an overall glucose-stabilizing effect, whereas pasireotide leads to increased and sustained hyperglycaemia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diazoxide and SSTR analogs have been used with varying success in PBH.
“Diazoxide and SSTR analogs have also been used with varying success [59-61].”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [61]
Cites
International consensus on use of continuous glucose monitoring
Danne, T., Nimri, R., Battelino, T., Bergenstal, R. M., Close, K. L., DeVries, J. H., Garg, S., Heinemann, L., Hirsch, I., Amiel, S. A., et al. (2017) · Diabetes Care · doi:10.2337/dc17-1600 · Cited by 2,069 · see citing works
Glucose-Dependent Insulinotropic Polypeptide
Christensen, M., Vedtofte, L., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2011) · Diabetes · doi:10.2337/db11-0979 · Cited by 353 · see citing works
Self-citationLiraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics
Jacobsen, L. V., Flint, A., Olsen, A. K., & Ingwersen, S. H. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0343-6 · Cited by 217 · see citing works
Dirksen, C., Damgaard, M., Bojsen‐Møller, K. N., Jørgensen, N. B., Kielgast, U., Jacobsen, S. H., Naver, L. S., Worm, D., Holst, J. J., Madsbad, S., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12087 · Cited by 184 · see citing works
Arts, J., Caenepeel, P., Bisschops, R., Dewulf, D., Holvoet, L., Piessevaux, H., Bourgeois, S., Sifrim, D., Janssens, J., & Tack, J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.11.025 · Cited by 142 · cited 1× · see citing works
“statin analogues in PBH, although hypoglycaemia was not always completely averted.(14,28) Pasireotide has a multi-receptor binding pro-”
BackgroundSalehi, M., Gastaldelli, A., & D'Alessio, D. A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2686 · Cited by 130 · see citing works
Abrahamsson, N., Engström, B. E., Sundbom, M., & Karlsson, F. A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0504 · Cited by 99 · see citing works
Ritz, P., Vaurs, C., Bertrand, M., Anduze, Y., Guillaume, E., & Hanaire, H. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0302 · Cited by 74 · see citing works
de Heide, L. J. M., Laskewitz, A. J., & Apers, J. A. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.11.006 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cummings, C., Jiang, A., Sheehan, A., Ferraz‐Bannitz, R., Puleio, A., Simonson, D. C., Dreyfuss, J. M., & Patti, M. E. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15096 · Cited by 27 · see citing works
Stocker, R., Ceyhan, M., Schönenberger, K. A., Stanga, Z., & Reber, E. (2022) · Nutrition · doi:10.1016/j.nut.2021.111577 · Cited by 24 · see citing works
Ding, B., Hu, Y., Yuan, L., Yan, R.-N., & Ma, J.-H. (2021) · Medicine · doi:10.1097/md.0000000000026086 · Cited by 13 · see citing works
Non-Diabetic Hypoglycemia: Evaluation and Management in Adults
Looi, E., & Lawler, H. M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134393 · Cited by 10 · see citing works
“Diazoxide and SSTR analogs have also been used with varying success [59–61].”
- Authors
- Øhrstrøm, C. C., Worm, D., Højager, A., Andersen, D., Holst, J. J., Kielgast, U. L., & Hansen, D. L.
- Affiliations
- Zealand University Hospital Køge (DK)
- Amager Hospital (DK)
- University of Copenhagen (DK)
- Steno Diabetes Center Copenhagen (DK)
- Corresponding author
- Øhrstrøm, Caroline Christfort
- ORCID
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2019-06-24
- Volume
- 21
- Issue
- 9
- Pages
- 2142-2151
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2947147808
- Cited by
- 72
- References
- 9
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 1
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Familien Hede Nielsens Fond
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- postprandial hypoglycemia, Roux-en-Y gastric bypass, bariatric surgery, acarbose, sitagliptin, verapamil, liraglutide, pasireotide, mixed meal tolerance test, continuous glucose monitoring, glycemic variability, hyperglycemia, insulin, C-peptide, glucagon-like peptide-1
- MeSH terms
- Sitagliptin Phosphate, Liraglutide, Adult, Blood Glucose, Female, Humans, Hypoglycemia, Hypoglycemic Agents, Male, Middle Aged, Obesity, Morbid, Postoperative Complications, Somatostatin, Verapamil, Blood Glucose Self-Monitoring, Gastric Bypass, Treatment Outcome, Cross-Over Studies, Postprandial Period, Acarbose, Glucagon-Like Peptide 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
