Remission of type 2 diabetes following long‐term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11‐year data from a real‐world registry study
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Aims: To investigate whether testosterone therapy (TTh) in men with hypogonadism and type 2 diabetes mellitus (T2DM) improves glycaemic control and insulin sensitivity, and results in remission of T2DM. Material and Methods: A total of 356 men who had total testosterone levels ≤12.1 nmol/L (350 ng/dL) and symptoms of hypogonadism were included in the study and followed up for 11 years. All patients received standard diabetes treatment and 178 patients additionally received parenteral testosterone undecanoate 1000 mg every 12 weeks following an initial 6‐week interval. A control group comprised 178 hypogonadal patients who opted not to receive TTh. Results: Patients with hypogonadism and T2DM treated with testosterone had significant progressive and sustained reductions in fasting glucose, glycated haemoglobin (HbA1c) and fasting insulin over the treatment period. In the control group, fasting glucose, HbA1c and fasting insulin increased. Among the patients treated with testosterone 34.3% achieved remission of their diabetes and 46.6% of patients achieved normal glucose regulation. Of the testosterone‐treated group, 83.1% reached the HbA1c target of 47.5 mmol/mol (6.5%) and 90% achieved the HbA1c target of 53.0 mmol/mol (7%). In contrast, no remission of diabetes or reductions in glucose or HbA1c levels were noted in the control group. There were fewer deaths, myocardial infarctions, strokes and diabetic complications in the testosterone‐treated group. Conclusions: Long‐term TTh in men with T2DM and hypogonadism improves glycaemic control and insulin resistance. Remission of diabetes occurred in one‐third of the patients. TTh is potentially a novel additional therapy for men with T2DM and hypogonadism.
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Haider et al. reported in a prospective registry study over 11 years in 178 men with lowered serum testosterone, that testosterone treatment was associated with type 2 diabetes remission in 34.3% of patients.
“Moreover, Haider et al. reported in a prospective registry study over 11 years in 178 men with lowered serum testosterone, that testosterone treatment was associated with type 2 diabetes remission in 34.3% of patients. 95”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [95]
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- Authors
- Haider, K. S., Haider, A., Saad, F., Doros, G., Hanefeld, M., Dhindsa, S., Dandona, P., & Traish, A.
- Affiliations
- Private Urology Practice Bremerhaven Germany
- Gulf Medical University (AE)
- Boston University (US)
- Zentrum für klinische Studien GWT‐TU Dresden GmbH Dresden Germany
- Saint Louis University (US)
- Kaleida Health (US)
- Corresponding author
- Traish, Abdulmaged
- ORCID
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2020-07-15
- Volume
- 22
- Issue
- 11
- Pages
- 2055-2068
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- PMC
- PMC7689919
- OpenAlex
- W3036206394
- Cited by
- 82
- References
- 48
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 18 · 2022: 18 · 2021: 19 · 2020: 6
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Obesity and Metabolism (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Bayer
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- testosterone undecanoate, testosterone replacement therapy, type 2 diabetes remission, hypogonadism, glycemic control, insulin sensitivity, insulin resistance, HbA1c, fasting blood glucose, men, long-term treatment outcomes, cardiovascular events
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Humans, Hypogonadism, Male, Registries, Testosterone
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