The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
Abstract
Acne vulgaris is a chronic inflammatory skin disease that mostly develops during adolescence and continues throughout adulthood. It affects the face, the main location of cosmetic appearance. Despite many developments in acne treatment, various combination therapies are needed to create the best option. Ninety patients were included in this study. We used the global acne grading system (GAGS) and the lesion counting and photographic standards that were used by Hayashi et al., to assess acne severity. The patients were randomly divided into three groups as group 1 (using only 5% BPO, twice a day), group 2 (using only the combination of 5% BPO + 3% erythromycin, twice a day), and group 3 (using only the combination of 4% niacinamide + 1% gallic acid + 1% lauric acid, twice a day). Thirty patients were included in each group. The scores were evaluated at weeks 0, 2, 4 and 8, and compared with each other. As a result of the study, all three treatment types were found to be effective. The combination of 4% niacinamide + 1% gallic acid + 1% lauric acid can be used as an alternative topical treatment for acne vulgaris to prevent resistance against topical antibiotics and the side effects of some other treatments.
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In the citing paper
“Three of the lower quality studies reported significantly superior improvements in the acne lesion counts compared to placebo or comparators”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“the remaining three with no comparators reported 40%–80% improvement in global scoring.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“Two of the non‐RCTs reported significantly superior improvements in the global assessment versus comparators or placebo”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“the remainder had no comparator arms but reported reductions of 40%–95% in acne lesions.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
Citations
Cites
Thiboutot, D. M., Gollnick, H. P. M., Bettoli, V., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. R., Lozada, V. T., Berson, D. S., Finlay, A. Y., et al. (2009) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.01.019 · Cited by 865
A comparison of current acne grading systems and proposal of a novel system
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Establishment of grading criteria for acne severity
Hayashi, N., Akamatsu, H., Kawashima, M., & Acne Study Group (2008) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2007.00403.x-i1 · Cited by 161
The role of topical dermocosmetics in acne vulgaris
Araviiskaia, E., & Dréno, B. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13579 · Cited by 123
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The role of nicotinamide in acne treatment
Walocko, F. M., Eber, A. E., Keri, J. E., Alharbi, M. A., & Nouri, K. (2017) · Dermatologic Therapy · doi:10.1111/dth.12481 · Cited by 64
Diseases of the Sebaceous Glands
Braun‐Falco, O., Plewig, G., Wolff, H. H., & Burgdorf, W. H. C. (2000) · Springer eBooks · doi:10.1007/978-3-642-97931-6_28 · Cited by 51
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Research works printed but not linked: 1
- Tuzun Y, 2004, Güncel Akne Tedavisi, Dermatose, 3, 220
Cited by
Cano, R., Bermúdez, V., Galbán, N., Garrido, B., Santeliz, R., Gotera, M. P., Durán, P., Boscan, A., Carbonell, A., Durán‐Agüero, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169118 · Cited by 66
A Comprehensive Update on the Bioactive Compounds from Seagrasses
Gono, C. M. P., Ahmadi, P., Hertiani, T., Septiana, E., Putra, M. Y., & Chianese, G. (2022) · Marine Drugs · doi:10.3390/md20070406 · Cited by 54
Garduño-Jiménez, A.-L., Durán–Álvarez, J. C., Ortori, C. A., Abdelrazig, S., Barrett, D. A., & Gomes, R. L. (2023) · Water Research · doi:10.1016/j.watres.2023.119903 · Cited by 55
Niacinamide: a review on dermal delivery strategies and clinical evidence
Ong, R. R., & Goh, C. F. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01593-y · Cited by 44
“Furthermore, acne, a distinctive inflammatory skin condition, was also explored, with 7% of the studies indicating a reduction in acne lesion counts, a lowered acne severity and an improved grading score [14, 15, 75, 77].”
International expert consensus recommendations for the use of dermocosmetics in acne.
Thiboutot, D., Layton, A. M., Traore, I., Gontijo, G., Troielli, P., Ju, Q., Kurokawa, I., & Dreno, B. (2025) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20145 · Cited by 32
Metadata
- Authors
- Kozan, A., Guner, R. Y., & Akyol, M.
- Affiliations
- Amasya Üniversitesi (TR)
- Dermatology Department Cumhuriyet University School of Medicine Sivas Turkey
- Sivas Cumhuriyet Üniversitesi (TR)
- Venue
- Dermatologic Therapy
- Publisher
- Wiley
- Published
- 2020-06-25
- Volume
- 33
- Issue
- 4
- Pages
- e13534-e13534
- ISSN
- 1396-0296 (ISSN-L)
- 1529-8019
- OpenAlex
- W3023836922
- Cited by
- 15
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Dermatologic Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- acne, benzoyl peroxide, nicotinamide, gallic acid, lauric acid, erythromycin, topical combination therapy, acne severity assessment, Global Acne Grading System, antibiotic resistance prevention, treatment efficacy
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Anti-Bacterial Agents, Benzoyl Peroxide, Dermatologic Agents, Erythromycin, Gallic Acid, Gels, Humans, Lauric Acids, Niacinamide, Retrospective Studies, Treatment Outcome
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- CoChat. (2026). Citation check: A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. https://app.cochat.ai/papers/10.1111/dth.13534
- The paper
- Kozan, A., Guner, R. Y., & Akyol, M. (2020). A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. Dermatologic Therapy. https://doi.org/10.1111/dth.13534
