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Cited by 42Dermatologic Treatments and Researchmelanin and skin pigmentationFacial Rejuvenation and Surgery Techniques

Management of periorbital hyperpigmentation: An overview of nature‐based agents and alternative approaches

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Sawant, Omkar, Khan, Tabassum·2020·Dermatologic Therapy
DOI 10.1111/dth.13717
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Abstract

Periorbital hyperpigmentation (POH) is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids, and it is commonly found in females belonging to the age group of 16 to 45 years. The data presented in this review include studies conducted on patients with a clinical/histological diagnosis of POH or melasma. Many diverse topical depigmenting agents comprising an array of naturally obtained actives such as arabinoxylans, α-arbutin, asiaticoside, azelaic acid, beta-carotene, boswellic acid, caffeine, chrysin, curcumin, cyanidin-3-glucoside, d-glucoronic acid, dihydrochalcone, dipalmitoyl-hydroxyprolene, fucoxanthin, genistein, glabridin, b-glucogallin, hyaluronic acid, lactic acid, lycopene, niacinamide, pycnogenol, retinol, salidroside, and xymenynic acid demonstrated significant benefits in the management of POH. An exhaustive literature search revealed that other techniques such as blepharoplasty, carboxytherapy, calcium hydroxylapatite fillers, tear trough implant, Q-switched ruby laser, medicated tattoo, fat transfer, micro-needling, chemical peels, nitrogen plasma skin regeneration, intense pulsed light, and radiofrequency have been evaluated and reported to be beneficial in the treatment of POH. The use of topical depigmenting agents is the most widely reported method in the clinical management of POH. Of these, α-arbutin, caffeine, cyanidin-3-glucoside, and dihydrochalcone are reported to exhibit significant benefits. Combination products containing a blend of actives are reported to be better than single active containing products. This review aims to provide a comprehensive perspective on the role of several topical actives in the modulation of melanin and tyrosinase biosynthesis pathway involved in the complex pathophysiology of POH. It also presents the advantages of combination products and other alternative therapies used in the management of POH.

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  • Topical treatments using madecassoside and asiaticoside improve hyperpigmentation.

    “Topical treatments using madecassoside 87 and asiaticoside. 88 , 89 show improvements in hyperpigmentation, 88 , 90 photoaging skin, cellulite and striae 91 and periocular wrinkles. 87 , 89 , 92”

    From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [88]

    Section 4.19 (Asiaticoside; page unavailable) reports that asiaticoside reduced melanin content in cultured melanoma cells. That supports an anti-pigmentation effect, but not improvement of hyperpigmentation from a topical treatment in people. The cited passages do not establish that effect for madecassoside. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Topical treatments using madecassoside and asiaticoside improve photoaging skin.

    “Topical treatments using madecassoside 87 and asiaticoside. 88 , 89 show improvements in hyperpigmentation, 88 , 90 photoaging skin, cellulite and striae 91 and periocular wrinkles. 87 , 89 , 92”

    From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [88]

    Section 4.19 reports that asiaticoside reduced melanin content in cultured melanoma cells, but does not report a topical treatment or improvement in photoaged skin. Searches for madecassoside and for topical photoaging effects of asiaticoside found no supporting passage in our copy. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 42

  1. Mi R, Chung K. Infraobital dark circles: definition, causes, and treat- ment options. Dermatol Surg. 2009;35(8):1163-1171. https://doi.org/ 10.1111/j.1524-4725.2009.01213.x. · DOI
  2. Desai SR, Alexis A, Sarkar R, Ranjan R, Sonthalia S. Periorbital hyper- pigmentation: a comprehensive review. J Clin Aesthet Dermatol. 2016; 9(1):49-55.
  3. Masson, F. Periorbital hyperpigmentation: What lies beneath? Indian Dermatol Online J. 2018;9(4):229-230. https://doi.org/10.4103/idoj.IDOJ · DOI
  4. Ahmed NA, Mohammed S. Treatment of periorbital dark circles: com- parative study of carboxy therapy vs chemical peeling vs mesotherapy. J Cosmet Dermatol. 2018;18(1):169-175. https://doi.org/10.1111/jocd. 12536. · DOI
  5. Sheth PB, Shah HA, Dave JN. Periorbital hyperpigmentation: a study of its prevalence, common causative factors and its association with personal habits and other disorders. Indian J Dermatol. 2014;59(2): 151-157. https://doi.org/10.4103/0019-5154.127675. · DOI
  6. Nouveau S, Agrawal D, Kohli M, Bernerd F, Misra N. Skin hyper- pigmentation in Indian population: insights and best practice. Indian J Dermatol. 2016;61(5):487-495. https://doi.org/10.4103/0019-5154. 190103. · DOI
  7. Grimes PE, Ijaz S, Nashawati R, Kwak D. New oral and topical approaches for the treatment of melasma. Int J Women Dermatol. 2019;5(1):30-36. https://doi.org/10.1016/j.ijwd.2018.09.004. · DOI
  8. D'Mello SAN, Finlay GJ, Baguley BC, Askarian-Amiri ME. Signalling pathways in melanogenesis. Int J Mol Sci. 2016;17(7):1144. https:// doi.org/10.3390/ijms17071144. · DOI
  9. Agarwal M. Treatment of dark circles with the new 15 mg/ml hyaluronic acid filler with lidocaine. Indian Dermatol Online J. 2019;10 (4):471-472. https://doi.org/10.4103/idoj.IDOJ. · DOI
  10. Ertam I, Mutlu B, Unal I, Alper S, Kivçak B, Ozer O. Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open- label study. J Dermatol. 2008;35:570-574. https://doi.org/10.1111/j. 1346-8138.2008.00522.x. · DOI
  11. Kircik LH. Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study. J Drug Dermatol. 2011;10(6): 586-590.
  12. Hashmi MI, Nazir S, Sulistyo J. Antimelanogenesis activity of poly- phenol glycoside synthesized by transglycosylation reaction of CGTase from Xanthomonas campestris. Int J Res Agric Food Sci. 2014;2(8):1-8.
  13. Radhakrishnan S, Shimmon R, Conn C, Baker A. Inhibitory kinetics of novel 2,3-dihydro-1H-inden-1-one chalcone-like derivatives on mushroom tyrosinase. Bioorg Med Chem Lett. 2015;25:5495-5499.
  14. Zhou Q, Feng C, Ruan Z. Inhibitory effect of a genistein derivative on pigmentation of Guinea pig skin. RSC Adv. 2017;7:7914-7919.
  15. Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from liquorice extracts on melanogenesis and inflammation. Pigment Cell Res. 1998;11:355-361.
  16. Misra BB, Dey S. TLC-bioautographic evaluation of in vitro anti- tyrosinase and anti-cholinesterase potentials of sandalwood oil. Nat Prod Commun. 2013;8(2):253-256.
  17. Pedretti A, Capezzera R, Zane C, Facchinetti E, Calzavara-Pinton P. Effects of topical boswellic acid on photo and age-damaged skin: clin- ical, biophysical, and echographic evaluations in a double-blind, ran- domized, split-face study. Planta Med. 2010;76:555-560.
  18. Zhang X, Hu X, Hou A, Wang H. Inhibitory effect of 2,4,2 0 ,4'- tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis. Biol Pharm Bull. 2009;32(1):86-90.
  19. Kar HK. Efficacy of beta-carotene topical application in melasma: an open clinical trial. Indian J Dermatol Venereol Leprol. 2002;68(6):320-322.
  20. Majeed M, Trinidad R, Chan G, et al. A randomized, double-blind, placebo-controlled, comparative study: The safety and efficacy of 0.25% tetrahydrocurcumin (turmeric) and 4% hydroquinone cream. Household Pers Care Today. n3/. 2010;21(2):2-4.
  21. Wanick F. Efficacy of lycopene, beta-carotene and Lactobacillus johnsonii in the maintenance treatment of melasma during the sum- mer. Surg Cosmet Dermatol. 2011;3(4):297-301.
  22. Hakozaki T, Minwalia L, Zhuang J, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Cutaneous Biol. 2002;147(1):20-31. https://doi.org/10. 1046/j.1365-2133.2002.04834.x. · DOI
  23. Singh R, Goyal S, Ahmed QR, Gupta N, Singh S. Effect of 82% lactic acid treatment of melasma. Inte Scholarly Res Notices. 2014;2014: 407142. https://doi.org/10.1155/2014/407142. · DOI
  24. Ortonne J-P. Retinoid therapy of pigmentary disorders. Dermatol Ther. 2006;19:280-288.
  25. Jung Kwon K, Bae S, Kim K, et al. Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. Mol Med Rep. 2014;10(1):503-507. https://doi.org/10.3892/mmr.2014.2159. · DOI
  26. Ahmadraji F, Shatalebi MA. Evaluation of the clinical efficacy and safety of an eye counter pad containing caffeine and vitamin K in emulsified Emu oil base. Adv Biomed Res. 2015;4:10. https://doi.org/ 10.4103/2277-9175.148292. · DOI
  27. Kim D-C, Rho S-H, Shin J-C, Park HH, Kim D. Inhibition of melano- genesis by 5,7-dihydroxyflavone (chrysin) via blocking adenylyl cyclase activity. Biochem Biophys Res Commun. 2011;411:121-125.
  28. Sonti S, Makino ET, Garruto JA, Gruder JV, Rao S, Mehta RC. Efficacy of novel treatment serum in the improvement of photodamaged skin. Int J Cosmet Sci. 2013;35(2):156-162.
  29. Adil M, Kaiser P, Satti NK, Zargar AM, Vishwakarma RA, Tasduq SA. Effect of Emblica officinalis (fruit) against UVB-induced photo-aging in human skin fibroblasts. J Ethnopharmacol. 2010;132:109-114.
  30. Peng L-H, Liu S, Xu S-Y, Chen L, Shan Y-H, Wei W. Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in Guinea pig skin. Phytomedicine. 2013;20(12): 1082-1087.
  31. Ni Z, Mu Y, Gulati O. Treatment of melasma with pycnogenol([R]). Phytother Res. 2002;16(6):567-571. https://doi.org/10.1002/ptr.1085. · DOI
  32. Colvan L, Tina BA, Bs F, Vega VL. Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sul- fate (LMW-HS) and a blend of naturally derived extracts. J Cosmet Dermatol. 2019;18:1-9. https://doi.org/10.1111/jocd.12857. · DOI
  33. Khan BA, Akhtar N, Mahmood T, Shoaib HM, Qayum M, Saeed T. Effects of antioxidants and flavonoids of sea buckthorn on skin whitening and skin erythema. Asian J Chem. 2011;23(2): 903-906.
  34. Naveed A, Mahmood A, Khan BA, Mahmood T. Exploring cucum- ber extract for skin rejuvenation. Afr J Biotechnol. 2011;10(7): 1206-1216.
  35. Eberlin S, Del Carmen Velazquez Pereda M, de Campos Dieamant G, Nogueira C, Werka RM, de Souza Queiroz ML. Effects of a Brazilian herbal compound as a cosmetic eyecare for periorbital hyperchromia ("dark circles"). J Cosmet Dermatol. 2009;8(2):127-135.
  36. Muhammad Shoaib Khan H, Naveed A, Bakhsh S, Caldeira EJ. Skin lightening and sebum control efficacy of a cosmetic emulsion con- taining extract of tamarind seeds on Asian skin type. Latin Am J Pharm. 2015;34(3):570-575.
  37. Vrcek I, Ozgur O, Nakra T. Infraorbital dark circles: a review of the pathogenesis, evaluation and treatment. J Cutan Aesthet Surg. 2016;9 (2):65-72. https://doi.org/10.4103/0974-2077.184046. · DOI
  38. Niamh Corduff, An alternative periorbital treatment option using cal- cium hydroxyapatite for hyperpigmentation associated with the tear trough deformity, Plast Reconstr Surg, 2020; 8(2): pe2633. https://doi. org/10.1097/GOX.0000000000002633, e2633 · DOI
  39. Mohan S, Mohan L, Sangal R, Singh N. Dermaroller in dermatology and cosmetology. Int J Res Dermatol. 2020;6(2):279-282. https://doi. org/10.18203/issn.2455-4529.IntJResDermatol20200614. · DOI
  40. Vavouli C, Katsambas A, Gregoriou S, et al. Chemical peeling with trichloroacetic acid and lactic acid for infraorbital dark circles. J Cosmet Dermatol. 2013;12:204-209.
  41. Kwon S-H, Choi J-Y, Ahn GY, et al. The efficacy and safety of micro- needle monopolar radiofrequency for the treatment of periorbital wrinkles. J Dermatol Treatment. 2019;10(3):1-5. https://doi.org/10. 1080/09546634.2019.1662880. · DOI
  42. Theppornpitak N, Udompataikul M, Chalermchai T, Ophaswongse S, Limtanyakul P. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: a prospective, randomized, controlled evaluator-blinded trial. J Cosmet Dermatol. 2018;18:1-6. https://doi.org/10.1111/jocd.12767. · DOI

Cited by

Sorted by citations

Authors
Sawant, O., & Khan, T.
Affiliations
Shri Vile Parle Kelavani Mandal (IN)
Corresponding author
Khan, Tabassum
ORCID
Venue
Dermatologic Therapy
Publisher
Wiley
Published
2020-07
Volume
33
Issue
4
Pages
e13717-e13717
ISSN
  • 1396-0296 (ISSN-L)
  • 1529-8019
DOI
10.1111/dth.13717
OpenAlex
W3029388339
Cited by
42
References
1
Citations by year
2026: 7 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 3
FWCI
0.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Dermatologic Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords
under-eye dark circles, melasma, topical depigmenting agents, α-arbutin, caffeine, cyanidin-3-glucoside, dihydrochalcones, combination products, melanogenesis, tyrosinase, blepharoplasty, carboxytherapy, Q-switched ruby laser, microneedling, chemical peels, intense pulsed light, radiofrequency, fat grafting
MeSH terms
Adolescent, Adult, Chemexfoliation, Eyelids, Female, Humans, Melanosis, Middle Aged, Hyperpigmentation, Blepharoplasty, Young Adult

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