Quality of life after bone sarcoma surgery around the knee: A long-term follow-up study
Open accessAbstract
It remains unclear if quality of life (QoL) improvements could be expected in young patients after malignant bone tumour surgery after 2 years. To assess the course of QoL over time during a long-term follow-up, malignant bone tumour survivors of a previous short-term study were included. Assessments were done at least 5 years after surgery. QoL was measured with Short-form (SF)-36, TNO-AZL Questionnaire for Adult's Quality of Life (TAAQOL) and Bone tumour (Bt)-DUX. QoL throughout the follow-up was analysed by linear mixed model analysis. From the original cohort of 44 patients; 20 patients were included for this study, 10 males; mean age at surgery 15.1 years and mean follow-up 7.2 years. Twenty-one patients of the initial cohort (47%) deceased. Fifteen patients (75%) underwent limb-salvage and five (25%) ablative surgery. QoL improved significantly during follow-up at Physical Component Summary Scale scale of the SF-36 and TAAQOL and all subscales of the Bt-DUX (p < .01). No significant differences were found between current evaluations and previous evaluations at 2 years after surgery (p = .41-.98). Significant advantages after limb-salvage were seen at the PCS scale of the SF-36 (MD 13.7, p = .05) and the cosmetic scale of the Bt-DUX (MD 17.7, p = .04).
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A cross-sectional Dutch study compared the HRQoL of patients who underwent resection of a malignant bone tumour from the lower extremity with that of healthy controls.
“A cross-sectional Dutch study compared the HRQoL of patients who underwent resection of a malignant bone tumour from the lower extremity with that of healthy controls 179 .”
From Osteosarcoma (2022) · cites this paper as [179]
Patients who had undergone surgery had lower scores for motor function, cognitive function, pain and general health.
“Patients who had undergone surgery had lower scores for motor function, cognitive function, pain and general health.”
From Osteosarcoma (2022) · cites this paper as [179]
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Cited by
Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
- Authors
- Bekkering, W. P., van Egmond-van Dam, J. C., Bramer, J. A. M., Beishuizen, A., Fiocco, M., & Dijkstra, P. D. S.
- Affiliations
- Leiden University Medical Center (NL)
- Department of Orthopaedics, Rehabilitation and Physical Therapy; Willem-Alexander Children's Hospital; Leiden University Medical Centre; Leiden The Netherlands
- Amsterdam UMC Location University of Amsterdam (NL)
- Erasmus MC (NL)
- Leiden University (NL)
- Corresponding author
- Bekkering, W.P.
- Venue
- European Journal of Cancer Care
- Publisher
- Hindawi Limited
- Published
- 2016-11-07
- Volume
- 26
- Issue
- 4
- Pages
- e12603
- ISSN
- 0961-5423 (ISSN-L)
- OpenAlex
- W2556478845
- Cited by
- 28
- References
- 44
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 6
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Cancer Care (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Johanna Children Fund (2003/0111-161)
- Children Fund Adrian Foundation (2003/0111)
- BIO-Children Rehabilitation Fund (2003/0131-161)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- bone sarcoma, quality of life, knee joint, limb salvage, amputation, long-term follow-up, SF-36, physical function, cosmetic outcome, adolescents
- MeSH terms
- Adolescent, Bone Neoplasms, Female, Follow-Up Studies, Humans, Knee Joint, Long-Term Care, Male, Quality of Life, Osteosarcoma, Salvage Therapy, Young Adult
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