Intrahepatic cholestasis in common chronic liver diseases
Abstract
Background and objective: Cholestasis represents the consequence of impaired bile formation and decrease in bile flow, generally classified as extra‐ and intrahepatic. Cholestasis is the pivotal hallmark of the so‐called primary cholestatic liver diseases but may also emerge in other forms of chronic liver injury. The aim now was to summarise the current state of knowledge on intrahepatic cholestasis related to chronic liver diseases. Methods: For this overview on intrahepatic cholestasis in chronic liver disorders other than the ‘classic’ cholestatic liver diseases, selected references were retrieved by literature search in MEDLINE and textbooks were reviewed. All articles were selected that discussed pathophysiological and clinical aspects of intrahepatic cholestasis in the context of alcoholic liver disease, nonalcoholic fatty liver disease, chronic hepatitis B and C virus infections as well as drug‐induced and granulomatous liver diseases. Titles referring to primary biliary cirrhosis and sclerosing cholangitis were excluded. Results and conclusions: Dependent on the aetiology, intrahepatic cholestasis is present at variable frequencies and in different disease stages in chronic liver diseases. Cholestasis secondary to chronic liver injury may denote a severe disease course and development of end‐stage liver disease or specific disease variants. These findings indicate that ‘secondary intrahepatic cholestasis’ (SIC) can occur in the natural course of chronic liver diseases other than the primary cholestatic diseases, in particular in the setting of advanced disease progression.
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Cholestasis results from different primary aetiologies but also is a frequent secondary event occurring during most chronic liver diseases.
“Cholestasis results from different primary aetiologies but also is a frequent secondary event occurring during most chronic liver diseases16.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [16]
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Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice
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- Authors
- Jüngst, C., Berg, T., Cheng, J., Green, R. M., Jia, J., Mason, A. L., & Lammert, F.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- University Hospital Leipzig (DE)
- Capital Medical University (CN)
- Northwestern University (US)
- University of Alberta (CA)
- Corresponding author
- Jüngst, Christoph
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2013-08-08
- Volume
- 43
- Issue
- 10
- Pages
- 1069-1083
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2031961630
- Cited by
- 82
- References
- 127
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- intrahepatic cholestasis, chronic liver disease, alcoholic liver disease, non-alcoholic fatty liver disease, chronic hepatitis B, chronic hepatitis C, drug-induced liver injury, granulomatous liver disease, end-stage liver disease
- MeSH terms
- Cholestasis, Intrahepatic, Chronic Disease, Fatty Liver, Granuloma, Hepatitis, Hepatitis, Viral, Human, Humans, Liver Diseases, Alcoholic, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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