Non‐anaemic iron deficiency – a disease looking for recognition of diagnosis: a systematic review
Abstract
Objective To capture all data meeting a rigid definition of non-anaemic iron deficiency (NAID) and determine whether it is associated with poor outcomes compared with normal iron status and whether iron supplementation improves outcomes in NAID. Design Systematic review. Data sources EMBASE, Medline, Web of Science, clinicaltrials.gov, International Clinical Trials Registry Platform (ICTRP) and Central from database inception to April 2014. Eligibility criteria Ferritin Results There were 21 studies included. NAID in pregnancy associated with reduction in birthweight (P = 0.028). Iron supplementation in NAID was associated with improvement in objective scores (P = 0.005) and self-rating (P = 0.03) of fatigue. Meta-analysis was limited and, where possible, was not statistically significant including the comparison of NAID with cardiovascular function in adults (VO2max P = 0.21, RERmax P = 0.68), educational attainment in children (P = 0.14), infant mental (P = 0.29) and psychomotor (P = 0.07) development, and iron supplementation in NAID with educational attainment in language (P = 0.31). Conclusions There is emerging evidence that NAID is a disease in its own right, deserving of further research in the development of strategies for detection and treatment.
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Two systematic reviews including pregnant women, blood donors and children concluded benefit of iron supplementation, although in the review by Yokoi and Konomi, the benefit was limited to randomised controlled trials.
“Two systematic reviews included studies of pregnant women, blood donors and children and included data from both randomised and non-randomised trials.38 39 These studies concluded benefit of iron supplementation, although in the review by Yokoi and Konomi39, the benefit was limited to randomised controlled trials.”
From Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials (2018) · cites this paper as [38]
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BackgroundDiagnosis and Management of Iron-Deficiency Anaemia
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“Two systematic reviews included studies of pregnant women, blood donors and children and included data from both randomised and non-randomised trials.(38) 39 These studies concluded benefit of iron supplementation, although in the review by Yokoi and Konomi(39), the benefit was limited to randomised controlled trials.”
BackgroundHow do we manage iron deficiency after blood donation?
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- Authors
- Pratt, J. J., & Khan, K. S.
- Affiliations
- Royal Children's Hospital (AU)
- Queen Mary University of London (GB)
- Corresponding author
- Pratt, Jeremy J.
- Venue
- European Journal of Haematology
- Publisher
- Wiley
- Published
- 2015-09-17
- Volume
- 96
- Issue
- 6
- Pages
- 618-628
- ISSN
- 0902-4441 (ISSN-L)
- 1600-0609
- OpenAlex
- W1900257882
- Cited by
- 126
- References
- 3
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 4 · 2015: 3
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal Of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- iron deficiency, ferritin, iron supplementation, pregnancy, birth weight, fatigue, cardiovascular function, VO2max, educational attainment, infant development, psychomotor development, disease identification
- MeSH terms
- Clinical Studies as Topic, Iron Deficiencies, Diagnosis, Differential, Female, Ferritins, Humans, Iron, Male, Phenotype, Pregnancy, Dietary Supplements
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