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Epilepsy biomarkers
Abstract
Summary: A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of tissue capable of generating spontaneous seizures; measure progression after the condition is established; and determine pharmacoresistance. Such biomarkers could be used to create animal models for more cost‐effective screening of potential antiepileptogenic and antiseizure drugs and devices, and to reduce the cost of clinical trials by enriching the trial population, and acting as surrogate markers to shorten trial duration. The objectives of the biomarker subgroup for the London Workshop were to define approaches for identifying possible biomarkers for these purposes. Research to identify reliable biomarkers may also reveal underlying mechanisms that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compounds.
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“The identification of molecule(s) within an easy-to-access biofluid such as blood would revolutionize the diagnosis of epilepsy (Engel Jr. et al., 2013).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Engel Jr. et al., 2013
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Research works printed but not linked: 12
- 10.1111/j.1528-1167.2010.02522.x · DOI · Paper page
- Engel J, 1989, Seizures and Epilepsy, 536
- 10.2217/bmm.11.62 · DOI
- 10.2217/bmm.11.71 · DOI
- 10.1097/WNP.0b013e3181fe0585 · DOI
- 10.1602/neurorx.1.2.189 · DOI
- 10.2217/bmm.11.68 · DOI
- 10.1111/j.1528-1167.2010.02635.x · DOI
- 10.1016/j.neulet.2011.02.041 · DOI
- 10.1111/j.1528-1167.2007.01294.x · DOI
- 10.2217/bmm.11.72 · DOI
- 10.2217/bmm.11.74 · DOI
Cited by
Sorted by citations
A forward-looking review of seizure prediction
Freestone, D. R., Karoly, P. J., & Cook, M. J. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000429 · Cited by 169
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brindley, E., Heiland, M., Mooney, C., Diviney, M., Mamad, O., Hill, T. D. M., Yan, Y., Venø, M. T., Reschke, C. R., Batool, A., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1230942 · Cited by 21
Metadata
- Authors
- Engel, J., Pitkänen, A., Loeb, J. A., Edward Dudek, F., Bertram, E. H., Cole, A. J., Moshé, S. L., Wiebe, S., Jensen, F. E., Mody, I., Nehlig, A., & Vezzani, A.
- Affiliations
- Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California U.S.A
- Department of Neurobiology A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland Kuopio Finland
- Department of Neurology and Rehabilitation University of Illinois at Chicago Chicago Illinois U.S.A
- Department of Neurology University of Utah School of Medicine Salt Lake City Utah U.S.A
- Department of Neurology University of Virginia Charlottesville Virginia U.S.A
- Epilepsy Service Massachusetts General Hospital Boston Massachusetts U.S.A
- Saul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience Department of Pediatrics Laboratory of Developmental Epilepsy Montefiore/Einstein Epilepsy Management Center Albert Einstein College of Medicine and Montefiore Medical Center Bronx NewYork U.S.A
- Department of Clinical Neurosciences University of Calgary Alberta Canada
- Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania U.S.A
- INSERM U 663 Necker Hospital Paris France
- Department of Neurosicience Mario Negri Institute Milan Italy
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2013-08
- Volume
- 54
- Issue
- s4
- Pages
- 61-69
- ISSN
- 0013-9580
- 1528-1167
- PMC
- PMC4131763
- Cited by
- 252
- References
- 0
- Language
- en
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