Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Open accessAbstract
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels of various microRNAs (miRNAs). Evidence is lacking, however, as to whether any of the circulating pool of miRNAs originates from the brain. To explore the link between circulating miRNAs and the pathophysiology of epilepsy, we first sequenced argonaute 2 (Ago2)-bound miRNAs in plasma samples collected from mice subject to status epilepticus induced by intraamygdala microinjection of kainic acid. This identified time-dependent changes in plasma levels of miRNAs with known neuronal and microglial-cell origins. To explore whether the circulating miRNAs had originated from the brain, we generated mice expressing FLAG-Ago2 in neurons or microglia using tamoxifen-inducible Thy1 or Cx3cr1 promoters, respectively. FLAG immunoprecipitates from the plasma of these mice after seizures contained miRNAs, including let-7i-5p and miR-19b-3p. Taken together, these studies confirm that a portion of the circulating pool of miRNAs in experimental epilepsy originates from the brain, increasing support for miRNAs as mechanistic biomarkers of epilepsy.
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Cites
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751 · see citing works
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599 · see citing works
An atlas of active enhancers across human cell types and tissues
The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550 · see citing works
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941 · see citing works
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works
Characterization of microRNA expression profiles in normal human tissues
Liang, Y., Ridzon, D., Wong, L., & Chen, C. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-166 · Cited by 1,015 · see citing works
Negative feedback control of neuronal activity by microglia
Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. T., Graves, S. M., Uweru, J. O., et al. (2020) · Nature · doi:10.1038/s41586-020-2777-8 · Cited by 979 · see citing works
Distribution of miRNA expression across human tissues
Ludwig, N., Leidinger, P., Becker, K., Backes, C., Fehlmann, T., Pallasch, C., Rheinheimer, S., Meder, B., Stähler, C., Meese, E., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw116 · Cited by 968 · see citing works
Moshé, S. L., Perucca, E., Ryvlin, P., & Tomson, T. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60456-6 · Cited by 905 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 865 · see citing works
Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
van Vliet, E. A., da Costa Araujo, S., Redeker, S., van Schaik, R., Aronica, E., & Gorter, J. A. (2007) · Brain · doi:10.1093/brain/awl318 · Cited by 775 · see citing works
Argonaute Proteins: Mediators of RNA Silencing
Peters, L., & Meister, G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.001 · Cited by 695 · see citing works
Small RNA sorting: matchmaking for Argonautes
Czech, B., & Hannon, G. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2916 · Cited by 692 · see citing works
Huse, J. T., Brennan, C., Hambardzumyan, D., Wee, B., Pena, J., Rouhanifard, S. H., Sohn-Lee, C., le Sage, C., Agami, R., Tuschl, T., et al. (2009) · Genes & Development · doi:10.1101/gad.1777409 · Cited by 511 · see citing works
MicroRNA expression in the adult mouse central nervous system
Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463 · see citing works
Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause
Zaidi, A., Clough, P., Cooper, P., Scheepers, B., & Fitzpatrick, A. P. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00700-2 · Cited by 422 · see citing works
Click Chemistry in Proteomic Investigations
Parker, C. G., & Pratt, M. R. (2020) · Cell · doi:10.1016/j.cell.2020.01.025 · Cited by 386 · see citing works
The glymphatic system: Current understanding and modeling
Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V. J., Lilius, T. O., Lundgaard, I., Mardal, K., Martens, E. A., Mori, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104987 · Cited by 381 · see citing works
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors
Lee, E. J., Baek, M., Gusev, Y., Brackett, D. J., Nuovo, G. J., & Schmittgen, T. D. (2008) · RNA · doi:10.1261/rna.804508 · Cited by 333 · see citing works
MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response
Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330 · see citing works
Aronica, E., Fluiter, K., Iyer, A. M., Zurolo, E., Vreijling, J. P., van Vliet, E. A., Baayen, J. C., & Gorter, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07122.x · Cited by 311 · see citing works
MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice
Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M. J., Feinberg, P. A., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., et al. (2013) · Science · doi:10.1126/science.1244193 · Cited by 301 · see citing works
Self-citationmiRNA in situ hybridization in formaldehyde and EDC–fixed tissues
Pena, J., Sohn-Lee, C., Rouhanifard, S. H., Ludwig, J., Hafner, M., Mihailovic, A., Lim, C., Holoch, D., Berninger, P., Zavolan, M., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1294 · Cited by 292 · see citing works
Engel, J., Pitkänen, A., Loeb, J. A., Dudek, F. E., Bertram, E. H., Cole, A. J., Moshé, S. L., Wiebe, S., Jensen, F. E., Módy, I., et al. (2013) · Epilepsia · doi:10.1111/epi.12299 · Cited by 291 · see citing works
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works
Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
Li, T., Ren, G., Lusardi, T. A., Wilz, A., Lan, J. Q., Iwasato, T., Itohara, S., Simon, R. P., & Boison, D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33737 · Cited by 251 · see citing works
Dave, V. P., Ngo, T. A., Pernestig, A.-K., Tilevik, D., Kant, K., Nguyen, T. B., Wolff, A., & Bang, D. D. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0143-3 · Cited by 249 · see citing works
A Dynamic Search Process Underlies MicroRNA Targeting
Chandradoss, S. D., Schirle, N. T., Szczepaniak, M., MacRae, I. J., & Joo, C. (2015) · Cell · doi:10.1016/j.cell.2015.06.032 · Cited by 244 · see citing works
Guo, Z., Maki, M. L., Ding, R., Yang, Y., Zhang, B., & Xiong, L. (2014) · Scientific Reports · doi:10.1038/srep05150 · Cited by 227 · see citing works
Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma
Turchinovich, A. A., & Burwinkel, B. (2012) · RNA Biology · doi:10.4161/rna.21083 · Cited by 219 · see citing works
Gorter, J. A., Iyer, A. M., White, I., Colzi, A., van Vliet, E. A., Sisodiya, S. M., & Aronica, E. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.026 · Cited by 183 · see citing works
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 168 · see citing works
Self-citationRegulation of cell-type-specific transcriptomes by microRNA networks during human brain development
Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0265-3 · Cited by 166 · see citing works
Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy
Wang, J., Yu, J., Tan, L., Tian, Y., Ma, J., Tan, C., Wang, H.-F., Liu, Y., Tan, M., Jiang, T., et al. (2015) · Scientific Reports · doi:10.1038/srep09522 · Cited by 165 · see citing works
Microvascular stabilization via blood-brain barrier regulation prevents seizure activity
Greene, C., Hanley, N., Reschke, C. R., Reddy, A., Mäe, M. A., Connolly, R., Behan, C., O’Keeffe, E., Bolger, I., Hudson, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29657-y · Cited by 164 · see citing works
Self-citationSingle-neuron labeling with inducible Cre-mediated knockout in transgenic mice
Young, P. W., Qiu, L., Wang, D., Zhao, S., Gross, J., & Feng, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2118 · Cited by 160 · see citing works
Kumar, P., Lim, A. J. M., Hazirah, S. N., Chua, C. J. H., Ngoh, A. S. F., Poh, S. L., Yeo, T. H., Lim, J. Y. X., Ling, S. R., Sutamam, N. B., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01095-5 · Cited by 150 · see citing works
Mouri, G., Jimenez-Mateos, E. M., Engel, T., Dunleavy, M., Hatazaki, S., Paucard, A., Matsushima, S., Taki, W., & Henshall, D. C. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.061 · Cited by 149 · see citing works
Self-citationArgonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction
Schaefer, A., Im, H., Venø, M. T., Fowler, C. D., Min, A. K., Intrator, A., Kjems, J., Kenny, P. J., O’Carroll, D., & Greengard, P. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100451 · Cited by 146 · see citing works
Self-citationmiRNATissueAtlas2: an update to the human miRNA tissue atlas
Keller, A., Gröger, L., Tschernig, T., Solomon, J., Laham, O., Schaum, N., Wagner, V., Kern, F., Schmartz, G. P., Li, Y., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab808 · Cited by 143 · see citing works
The misdiagnosis of epilepsy: Appraising risks and managing uncertainty
Oto, M. (. (2017) · Seizure · doi:10.1016/j.seizure.2016.11.029 · Cited by 141 · see citing works
Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia
Ouyang, Y., Xu, L., Lu, Y., Sun, X., Yue, S., Xiong, X., & Giffard, R. G. (2013) · Glia · doi:10.1002/glia.22556 · Cited by 139 · see citing works
Geekiyanage, H., Rayatpisheh, S., Wohlschlegel, J. A., Brown, R. H., & Ambros, V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008323117 · Cited by 139 · see citing works
MicroRNA Let-7i Is a Promising Serum Biomarker for Blast-Induced Traumatic Brain Injury
Balakathiresan, N. S., Bhomia, M., Chandran, R., Chavko, M., McCarron, R. M., & Maheshwari, R. K. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.2146 · Cited by 135 · see citing works
McKiernan, R. C., Jimenez-Mateos, E. M., Bray, I. M., Engel, T., Brennan, G. P., Sano, T., Michalak, Z., Moran, C., Delanty, N., Farrell, M. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035921 · Cited by 128 · see citing works
Self-citationYan, S., Zhang, H., Xie, W., Meng, F., Zhang, K., Jiang, Y., Zhang, X., & Zhang, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13744 · Cited by 117 · see citing works
Raoof, R. M., Jimenez-Mateos, E. M., Bauer, S., Tackenberg, B., Rosenow, F., Lang, J., Onugoren, M. D., Hamer, H. M., Huchtemann, T., Körtvélyessy, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02969-6 · Cited by 111 · see citing works
Self-citationRaoof, R. M., Bauer, S., Naggar, H. E., Connolly, N. M. C., Brennan, G. P., Brindley, E., Hill, T., McArdle, H., Spain, E., Forster, R. J., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.068 · Cited by 111 · see citing works
Self-citationRoncon, P., Soukupovà, M., Binaschi, A., Falcicchia, C., Zucchini, S., Ferracin, M., Langley, S. R., Petretto, E. G., Johnson, M. R., Marucci, G., et al. (2015) · Scientific Reports · doi:10.1038/srep14143 · Cited by 107 · see citing works
Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap
Simonato, M., Agoston, D. V., Brooks‐Kayal, A. R., Dulla, C. G., Fureman, B. E., Henshall, D. C., Pitkänen, A., Theodore, W. H., Twyman, R. E., Kobeissy, F. H., et al. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00461-4 · Cited by 101 · see citing works
Self-citationManagement of psychogenic non‐epileptic seizures: a multidisciplinary approach
Gasparini, S., Beghi, E., Ferlazzo, E., Beghi, M., Belcastro, V., Biermann, K. P., Bottini, G., Capovilla, G., Cervellione, R., Cianci, V., et al. (2018) · European Journal of Neurology · doi:10.1111/ene.13818 · Cited by 100 · see citing works
Risbud, R. M., & Porter, B. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053464 · Cited by 90 · see citing works
Consensus miRNA expression profiles derived from interplatform normalization of microarray data
Bargaje, R., Hariharan, M., Scaria, V., & Pillai, B. (2010) · RNA · doi:10.1261/rna.1688110 · Cited by 81 · see citing works
Kaalund, S. S., Venø, M. T., Bak, M., Møller, R. S., Laursen, H. B., Madsen, F., Broholm, H., Quistorff, B., Uldall, P. V., Tommerup, N., et al. (2014) · Epilepsia · doi:10.1111/epi.12839 · Cited by 76 · see citing works
Self-citationNon-coding RNA in the wiring and remodeling of neural circuits
Soutschek, M., & Schratt, G. M. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.031 · Cited by 72 · see citing works
Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes
Thompson, R. C., Deo, M., & Turner, D. L. (2007) · Methods · doi:10.1016/j.ymeth.2007.04.008 · Cited by 69 · see citing works
Dubey, M., Pascual-Garcia, M., Helmes, K., Wever, D. D., Hamada, M. S., Kushner, S. A., & Kole, M. H. P. (2022) · eLife · doi:10.7554/elife.73827 · Cited by 66 · see citing works
Preventing misdiagnosis of epilepsy
Ferrie, C. D. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2005.088906 · Cited by 65 · see citing works
Opportunities and challenges for microRNA-targeting therapeutics for epilepsy
Morris, G., O’Brien, D., & Henshall, D. C. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.04.007 · Cited by 65 · see citing works
Self-citationTackling Epilepsy With High-definition Precision Medicine
KEARNEY, H. F., Byrne, S., Cavalleri, G. L., & Delanty, N. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2384 · Cited by 62 · see citing works
McArdle, H., Jimenez-Mateos, E. M., Raoof, R. M., Carthy, É., Boyle, D., Naggar, H. E., Delanty, N., Hamer, H. M., Dogan, M., Huchtemann, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01947-2 · Cited by 60 · see citing works
Self-citationLeontariti, M., Avgeris, M., Katsarou, M., Drakoulis, N., Siatouni, A., Verentzioti, A., Alexoudi, A., Fytraki, A., Patrikelis, P., Vassilacopoulou, D., et al. (2020) · Epilepsia · doi:10.1111/epi.16502 · Cited by 58 · see citing works
van Scheppingen, J., Iyer, A. M., Prabowo, A. S., Mühlebner, A., Anink, J. J., Scholl, T., Feucht, M., Jansen, F. E., Spliet, W. G., Krsek, P., et al. (2016) · Glia · doi:10.1002/glia.22983 · Cited by 57 · see citing works
Brennan, G. P., Bauer, S., Engel, T., Jimenez-Mateos, E. M., Gallo, F. D., Hill, T. D. M., Connolly, N. M. C., Costard, L. S., Neubert, V., Salvetti, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105048 · Cited by 54 · see citing works
Self-citationEnright, N., Simonato, M., & Henshall, D. C. (2018) · Epilepsia Open · doi:10.1002/epi4.12275 · Cited by 49 · see citing works
Self-citationMichalak, Z., Sano, T., Engel, T., Miller-Delaney, S. F. C., Lerner‐Natoli, M., & Henshall, D. C. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.10.006 · Cited by 44 · see citing works
Self-citationGlial responses during epileptogenesis in Mus musculus point to potential therapeutic targets
Kalozoumi, G., Kel-Margoulis, O. V., Vafiadaki, E., Greenberg, D., Gervais‐Bernard, H., Soreq, H., Depaulis, A., & Sanoudou, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201742 · Cited by 44 · see citing works
Reschke, C. R., Silva, L. F. A., Vangoor, V. R., Rosso, M., David, B., Cavanagh, B., Connolly, N. M. C., Brennan, G. P., Sanz‐Rodriguez, A., Mooney, C., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.021 · Cited by 42 · see citing works
Self-citationHeiland, M., Connolly, N. M. C., Mamad, O., Nguyen, T. N., Kesavan, J., Langa, E., Fanning, K., Sanfeliu, A., Yan, Y., Su, J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216658120 · Cited by 38 · see citing works
Self-citationBatool, A., Hill, T. D. M., Nguyen, T. N., Langa, E., Diviney, M., Mooney, C., Brennan, G. P., Connolly, N. M. C., Sanz‐Rodriguez, A., Cavanagh, B., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01404 · Cited by 35 · see citing works
Self-citationMartins-Ferreira, R., Chaves, J., Carvalho, C., Bettencourt, A., Chorão, R., Freitas, J., Samões, R., Boleixa, D., Lopes, J., Ramalheira, J. E. P., et al. (2019) · European Journal of Neurology · doi:10.1111/ene.14129 · Cited by 34 · see citing works
West, P. J., Thomson, K. E., Billingsley, P., Pruess, T. H., Rueda, C. B., Saunders, G. W., Smith, M. D., Metcalf, C. S., & Wilcox, K. S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113954 · Cited by 31 · see citing works
Let-7i inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia
Nguyen, T., Su, C., & Singh, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803384115 · Cited by 29 · see citing works
MicroRNA in situ hybridization in the human entorhinal and transentorhinal cortex
Nelson, P. T. (2010) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.007.2010 · Cited by 24 · see citing works
Ioriatti, E. S., Cirino, M. L. A., Neto, F. S. L., Velasco, T. R., Sakamoto, A. C., Freitas‐Lima, P., Tirapelli, D. P. D. C., & Carlotti, C. G. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106373 · Cited by 24 · see citing works
MicroRNAs as biomarkers and treatment targets in status epilepticus
Brindley, E., Hill, T. D. M., & Henshall, D. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.025 · Cited by 20 · see citing works
Self-citationHe, X., Wang, J., Du, H., Liu, C., & Teng, Z. (2022) · Cells · doi:10.3390/cells11081348 · Cited by 17 · see citing works
Diviney, M., Reynolds, J. R., & Henshall, D. C. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.07.038 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy
Chen, S., Huang, M. Y., Xu, D., & Li, M. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105657 · Cited by 19 · see citing works
Circulating miRNAs as Novel Clinical Biomarkers in Temporal Lobe Epilepsy
Guarnieri, L., Amodio, N., Bosco, F., Carpi, S., Tallarico, M., Gallelli, L., Rania, V., Citraro, R., Leo, A., & Sarro, G. D. (2024) · Non-Coding RNA · doi:10.3390/ncrna10020018 · Cited by 8 · see citing works
Leal, B., Carvalho, C., Santos, C., Samões, R., Martins-Ferreira, R., Teixeira, C., Rodrigues, D., Freitas, J., Lemos, C., Chorão, R., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1512860 · Cited by 8 · see citing works
Villena-Rueda, B. E., Kajitani, G. S., Ota, V., Mauer, J., Santoro, M. L., Bugiga, A., Rosa, J. S., Asprino, P. F., Meneghetti, P., Torrecilhas, A. C., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04194-5 · Cited by 8 · see citing works
van Vliet, E. A., Scheper, M., Mills, J. D., Puhakka, N., Szydłowska, K., Ferracin, M., Lovisari, F., Soukupovà, M., Zucchini, S., Srivastava, P. K., et al. (2024) · Epilepsia · doi:10.1111/epi.18134 · Cited by 6 · see citing works
Appropriate antibiotic prescribing for the general dentist.
Goodchild, J. H., & Donaldson, M. (2009) · PubMed · Cited by 6 · see citing works
Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases
Duarte, T. T., Rassi, D. M., Carvalho, A., Santos, D. E., Zanon, S., & Lucas, G. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70058 · Cited by 4 · see citing works
Henshall, D. C., & Simonato, M. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0037 · Cited by 3 · see citing works
Self-citationSamões, R., Cavalheiro, A., Santos, C., Lopes, J., Teixeira, C., Tavares, M. M., Carvalho, C., Lemos, C., Costa, P., Cavaco, S., et al. (2024) · Epilepsy Research · doi:10.1016/j.eplepsyres.2024.107478 · Cited by 3 · see citing works
Harnett, A., Mathoux, J., Wilson, M., Heiland, M., Mamad, O., Srinivas, S., Sanfeliu, A., Sanz‐Rodriguez, A., How, K. L. E., Delanty, N., et al. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16499 · Cited by 3 · see citing works
Self-citationZakaria, F., Yousef, S. A., AbdelDayem, J., ElGamal, R., Issa, O., Mansour, M., Bastorous, H., Emad, E., & Mahgoub, R. (2025) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-025-00791-9 · Cited by 2 · see citing works
Villalba‐Benito, L., Mathoux, J., Auer, T., Narasimhan, K., Colbert, R., Reynolds, J. R., Brindley, E., Batool, A., Hill, T. D. M., Diviney, M., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107284 · Cited by 2 · see citing works
Self-citationIFITM3-mediated neuroinflammation in epilepsy regulated by the let-7g-5p/STAT2 axis
Liu, J., Sheng, D., Li, X., Yazgulyyeva, B., Wang, Y., Xiao, B., & Liu, W. (2026) · Scientific Reports · doi:10.1038/s41598-026-44357-z · Cited by 2 · see citing works
MicroRNAs Fine-Tune Brain and Body Communication in Health and Disease
Henshall, D. C. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_12 · Cited by 2 · see citing works
Self-citationPerspective on adolescent psychiatric illness and emerging role of microRNAs as biomarkers of risk
Morgunova, A., Teixeira, M., & Flores, C. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.240072 · Cited by 2 · see citing works
Barreto, J. S. R., Estupiñan-Pepinosa, D. F., Correa-Molina, N., Niño-Muñoz, P. A., Aguirre-Patiño, J. S., Buitrago, C. A., Mayor, L. C., & Martínez-Micolta, P. (2025) · Neurosurgical Review · doi:10.1007/s10143-025-03988-y · Cited by 1 · see citing works
Grahe, C., Egleton, R. D., Santanam, N., & Bihl, J. C. (2026) · Biomolecules · doi:10.3390/biom16030463 · Cited by 1 · see citing works
Computational Analysis of Neurological Biomarkers for Mental Health Disorders
(2025) · Journal of Psychology and Neuroscience · doi:10.47485/2693-2490.1099
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Scheper, M., Liu, Z., Galanopoulou, A. S., Hlauschek, G., Sinclair, B., Leung, W. L., Dedeurwaerdere, S., Doran, E., Moshé, S. L., Henshall, D. C., et al. (2026) · Epilepsia · doi:10.1002/epi.70382
Self-citationRasheed, M. S., Akbar, I., Javed, U., Shakeel, M., Sajid, M., Sabir, A., Zafar, M., & Amjad, W. (2026) · ADMET & DMPK · doi:10.5599/admet.3591
- Authors
- Brindley, E., Heiland, M., Mooney, C., Diviney, M., Mamad, O., Hill, T. D. M., Yan, Y., Venø, M. T., Reschke, C. R., Batool, A., Langa, E., Sanz-Rodriguez, A., Heller, J. P., Morris, G., Conboy, K., Kjems, J., Brennan, G. P., & Henshall, D. C.
- Affiliations
- Royal College of Surgeons in Ireland (IE)
- University College Dublin (IE)
- Aarhus University (DK)
- Corresponding author
- Brennan, Gary P.
- Henshall, David C.
- ORCID
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-09-22
- Volume
- 16
- Pages
- 1230942-1230942
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC10556253
- OpenAlex
- W4386964088
- Semantic Scholar
- e440041451993f875a17032e8073790a631f0f3e
- Cited by
- 21
- References
- 84
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dublin City University Open Access Institutional Repository (Dublin City University) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust (222648/Z/21/Z)
- Royal College of Surgeons in Ireland
- European Commission (602130)
- Higher Education Authority
- Science Foundation Ireland (13/IA/1891, 16/RC/3948)
- HORIZON EUROPE Framework Programme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- circulating microRNAs, plasma biomarkers, temporal lobe epilepsy, status epilepticus, kainic acid, Argonaute 2, microglia, neurons, let-7i-5p, miR-19b-3p, blood-brain barrier, epilepsy diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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