The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Valproate in the treatment of epilepsy in girls and women of childbearing potential
Open accessAbstract
Summary: This document provides guidance on the use of valproate in girls and women of childbearing age from a joint Task Force of the Commission on European Affairs of the International League Against Epilepsy (CEA‐ILAE) and the European Academy of Neurology (EAN), following strengthened warnings from the Coordination Group for Mutual Recognition and Decentralised Procedures‐Human (CMD h) of the European Medicines Agency (EMA), which highlight the risk of malformations and developmental problems in infants who are exposed to valproate in the womb. To produce these recommendations, the Task Force has considered teratogenic risks associated with use of valproate and treatment alternatives, the importance of seizure control and of patient and fetal risks with seizures, and the effectiveness of valproate and treatment alternatives in the treatment of different epilepsies. The Task Force's recommendations include the following: (1) Where possible, valproate should be avoided in women of childbearing potential. (2) The choice of treatment for girls and women of childbearing potential should be based on a shared decision between clinician and patient, and where appropriate, the patient's representatives. Discussions should include a careful risk–benefit assessment of reasonable treatment options for the patient's seizure or epilepsy type. (3) For seizure (or epilepsy) types where valproate is the most effective treatment, the risks and benefits of valproate and other treatment alternatives should be discussed. (4) Valproate should not be prescribed as a first‐line treatment for focal epilepsy. (5) Valproate may be offered as a first‐line treatment for epilepsy syndromes where it is the most effective treatment, including idiopathic (genetic) generalized syndromes associated with tonic–clonic seizures. (6) Valproate may be offered as a first‐line treatment in situations where pregnancy is highly unlikely (e.g., significant intellectual or physical disability). (7) Women and girls taking valproate require regular follow‐up for ongoing consideration of the most appropriate treatment regimen.
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Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism
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Self-citationMeador, K. J., Baker, G. A., Browning, N., Cohen, M. J., Bromley, R. L., Clayton-Smith, J., Kalayjian, L. A., Kanner, A., Liporace, J. D., Pennell, P. B., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70323-x · Cited by 834
Tomson, T., Battino, D., Bonizzoni, E., Craig, J., Lindhout, D., Sabers, A., Perucca, E., & Vajda, F. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70107-7 · Cited by 751
Self-citationEthosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy
Glauser, T. A., Cnaan, A., Shinnar, S., Hirtz, D. G., Dlugos, D., Masur, D., Clark, P. O., Capparelli, E. V., & Adamson, P. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0902014 · Cited by 645
Comparative safety of antiepileptic drugs during pregnancy
Hernández-Díaz, S., Smith, C. R., Shen, A., Mittendorf, R., Hauser, W. A., Yerby, M., Holmes, L. B., For the North American AED Pregnancy Registry, North American AED (Antiepileptic Drug) Pregnancy Registry, Cragan, J., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182574f39 · Cited by 620
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Combined analysis of risk factors for SUDEP: Combined SUDEP Analysis
Hesdorffer, D. C., Tomson, T., Benn, E., Sander, J. W., Nilsson, L., Langan, Y., Walczak, T. S., Beghi, E., Brodie, M. J., Hauser, A., et al. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02952.x · Cited by 501
Self-citation(2009) · Neurology · doi:10.1212/wnl.0b013e3181a6b312 · Cited by 428
Cited by
Tomson, T., Battino, D., Bonizzoni, E., Craig, J., Lindhout, D., Perucca, E., Sabers, A., Thomas, S. V., Vajda, F., Faravelli, F., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30107-8 · Cited by 544
Self-citationHirsch, E., French, J., Scheffer, I. E., Bogacz, A., Alsaadi, T., Sperling, M. R., Abdulla, F., Zuberi, S. M., Trinka, E., Specchio, N., et al. (2022) · Epilepsia · doi:10.1111/epi.17236 · Cited by 502
Self-citationManagement of psychiatric and neurological comorbidities in epilepsy
Kanner, A. M. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.243 · Cited by 451
Tomson, T., Battino, D., & Perucca, E. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00314-2 · Cited by 266
Self-citationSafety and tolerability of histone deacetylase (HDAC) inhibitors in oncology
Shah, R. R. (2019) · Drug Safety · doi:10.1007/s40264-018-0773-9 · Cited by 197
Metadata
- Authors
- Tomson, T., Marson, A., Boon, P., Canevini, M. P., Covanis, A., Gaily, E., Kälviäinen, R., & Trinka, E.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2015-05-16
- Volume
- 56
- Issue
- 7
- Pages
- 1006-1019
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1910200371
- Cited by
- 267
- References
- 61
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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