The biodisposition and hypertrichotic effects of bimatoprost in mouse skin
Open accessAbstract
Studies on bimatoprost were performed with two objectives: (i) to determine whether bimatoprost possesses hair growth‐stimulating properties beyond eyelash hypertrichosis and (ii) to investigate the biodisposition of bimatoprost in skin for the first time. Bimatoprost, at the dose used clinically for eyelash growth (0.03%) and given once daily for 14 days, increased pelage hair growth in C57/black 6 mice. This occurred as a much earlier onset of new hair growth in shaved mice and the time taken to achieve complete hair regrowth, according to photographic documentation and visual assessment. Bimatoprost biodisposition in the skin was determined at three concentrations: 0.01%, 0.03% and 0.06%. Dose‐dependent Cmax values were obtained (3.41, 6.74, 12.3 μg/g tissue), and cutaneous bimatoprost was well maintained for 24 h following a single dose. Bimatoprost was recovered from the skin only as the intact molecule, with no detectable levels of metabolites. Thus, bimatoprost produces hypertrichosis as the intact molecule.
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The effect of bimatoprost on eyelash growth is thought to arise by interaction with prostamide-sensitive receptors in hair follicles.
“Eyelash growth was noted as an adverse effect of bimatoprost use in clinical trials of patients with glaucoma and ocular hypertension [9, 10, 12, 13], an effect thought to arise by the interaction of bimatoprost with prostamide-sensitive receptors in hair follicles [14].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [14]
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Research works printed but not linked: 20
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Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies
Harii, K., Arase, S., Tsuboi, R., Weng, E., Daniels, S., & VanDenburgh, A. (2014) · Aesthetic Plastic Surgery · doi:10.1007/s00266-014-0293-7 · Cited by 29 · see citing works
- Authors
- Woodward, D. F., Tang, E. S. ‐., Attar, M., & Wang, J. W.
- Affiliations
- Allergan (United States) (US)
- Corresponding author
- Wang, Jenny W.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2013-01-02
- Volume
- 22
- Issue
- 2
- Pages
- 145-148
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- PMC
- PMC3594970
- OpenAlex
- W1965746576
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2018: 1 · 2014: 3 · 2013: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- bimatoprost, hypertrichosis, eyelash growth, hair growth promotion, pharmacokinetics, Cmax, dose dependence, mouse skin
- MeSH terms
- Bimatoprost, Amides, Animals, Antihypertensive Agents, Cloprostenol, Dose-Response Relationship, Drug, Eyelashes, Hair, Hypertrichosis, Mice, Inbred C57BL, Prostaglandins, Skin, Time Factors, Mice
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