Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice
Open accessAbstract
The epidermal growth factor receptor (EGFR) system is an established regulator of the development and homeostasis of the hair follicle and interfollicular epidermis. Here, we evaluated EGFR actions on the sebaceous glands (SG s) by employing D sk5 mice, a mutant line in which the EGFR is constitutively activated in a ligand‐independent manner. Compared to control littermates, D sk5 mice showed increased sebum levels and enlarged SG s, which contained a higher number of cells and showed stronger proliferation. c‐myc transcript levels were increased in D sk5 skin, suggesting that c‐myc mediates the proliferative stimuli of the EGFR in the SG. Analysis of differentiation markers revealed deregulated expression of S cd1 and S cd3, indicating that sebaceous lipogenesis is affected in D sk5 mice. In conclusion, our study indicates that the EGFR is an important regulator of presebocyte proliferation, contributing to the final cell number, to the size and to the lipid output of SG s.
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EGF enhances sebocyte proliferation, enlarges SGs, and increases sebum production.
“Specifically, we used hFGF-2 as it can drive sebocyte proliferation and hypertrophy16, EGF was administered as it enhances sebocyte proliferation, enlarges SGs and increases sebum production17 as well as R-spondin1, which promotes Wnt signaling that drives SG generation18.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [17]
The Results report that mice with constitutively active EGFR had more proliferating gland cells, enlarged sebaceous glands, and higher sebum levels. But the study tested ligand-independent EGFR activation, not administered EGF. The Background also says EGF did not seem to increase proliferation of isolated human sebocytes and inhibited lipogenesis in human glands in vitro, so the claim overextends the mouse findings to EGF treatment. (LLM, conf=0.90)
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Cites
The epidermal growth factor receptor ligands at a glance
Schneider, M. R., & Wolf, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21635 · Cited by 447 · see citing works
Self-citationSignal transduction and oncogenesis by ErbB/HER receptors
Marmor, M. D., Skaria, K. B., & Yarden, Y. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.06.002 · Cited by 389 · see citing works
Deregulated expression of c-Myc depletes epidermal stem cells
Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318 · see citing works
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Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
Feldman, A., Mukha, D., Maor, I. I., Sedov, E., Koren, E., Yosefzon, Y., Shlomi, T., & Fuchs, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-10261-6 · Cited by 52 · see citing works
- Authors
- Dahlhoff, M., de Angelis, M. H., Wolf, E., & Schneider, M. R.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- German Research Center for Environmental Health (GmbH) Helmholtz Zentrum München Institute of Experimental Genetics Neuherberg Germany
- Corresponding author
- Schneider, Marlon R.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2013-09-23
- Volume
- 22
- Issue
- 10
- Pages
- 667-669
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2077799628
- Cited by
- 24
- References
- 3
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- epidermal growth factor receptor, ligand-independent receptor activation, sebaceous glands, sebum production, c-Myc, sebocyte differentiation, stearoyl-CoA desaturase 1, skin lipid metabolism
- MeSH terms
- Animals, Cell Differentiation, Epidermis, Female, Ligands, Lipids, Male, Sebaceous Glands, Sebum, Skin, Stearoyl-CoA Desaturase, Proto-Oncogene Proteins c-myc, Cell Lineage, Cell Proliferation, Mice, ErbB Receptors
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