The epidermal growth factor receptor ligands at a glance

Genes that mediate breast cancer metastasis to lung

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EGF–ERBB signalling: towards the systems level

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An Essential Role for Ectodomain Shedding in Mammalian Development

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

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Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

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Neuregulins: functions, forms, and signaling strategies

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EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle

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Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

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Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

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EGF receptor ligands

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Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

Sandgren, E. P., Luetteke, N., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90075-p · Cited by 752 · see citing works

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990) · Cell · doi:10.1016/0092-8674(90)90076-q · Cited by 709 · see citing works

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

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MEMBRANE-ANCHORED GROWTH FACTORS

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TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

Luetteke, N., Qiu, T. H., Peiffer, R. L., Oliver, P. M., Smithies, O., & Lee, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90228-i · Cited by 658 · see citing works

ErbB Receptors: Directing Key Signaling Networks Throughout Life

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The deaf and the dumb: the biology of ErbB-2 and ErbB-3

Citri, A. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00101-5 · Cited by 591 · see citing works

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., & Dunn, A. R. (1993) · Cell · doi:10.1016/0092-8674(93)90227-h · Cited by 583 · see citing works

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation

Das, S., Wang, X., Paria, B. C., Damm, D. L., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 568 · see citing works

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

Luetteke, N., Qiu, T. H., Fenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A. Y., & Lee, D. C. (1999) · Development · doi:10.1242/dev.126.12.2739 · Cited by 568 · see citing works

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

Wong, S. T., Winchell, L. F., McCune, B. K., Earp, H. S., Teixidó, J., Massagué, J., Herman, B., & Lee, D. C. (1989) · Cell · doi:10.1016/0092-8674(89)90252-3 · Cited by 475 · see citing works

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

Klapper, L. N., Glathe, S., Vaisman, N., Hynes, N. E., Andrews, G. C., Sela, M., & Yarden, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4995 · Cited by 455 · see citing works

The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation

Pastore, S., Mascia, F., Mariani, V., & Girolomoni, G. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701184 · Cited by 441 · see citing works

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L. M., & Coffey, R. J. (1990) · Cell · doi:10.1016/0092-8674(90)90077-r · Cited by 440 · see citing works

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

Brachmann, R. K., Lindquist, P. B., Nagashima, M., Kohr, W. J., Lipari, T., Napier, M. A., & Derynck, R. (1989) · Cell · doi:10.1016/0092-8674(89)90591-6 · Cited by 422 · see citing works

Defective valvulogenesis in HB‐EGF and TACE‐null mice is associated with aberrant BMP signaling

Jackson, L. F., Qiu, T. H., Sunnarborg, S. W., Chang, A., Zhang, C., Patterson, C., & Lee, D. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg264 · Cited by 417 · see citing works

EGFR signal transactivation in cancer cells

Fischer, O. M., Hart, S., Gschwind, A., & Ullrich, A. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311203 · Cited by 412 · see citing works

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.Preprint

Vassar, R. J., & Fuchs, E. V. (1991) · Genes & Development · doi:10.1101/gad.5.5.714 · Cited by 411 · see citing works

Autocrine, paracrine and juxtacrine signaling by EGFR ligands

Singh, A. B., & Harris, R. C. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.026 · Cited by 400 · see citing works

Role of the Epidermal Growth Factor Network in Ovarian Follicles

Conti, M., Hsieh, M., Park, J.-Y., & Su, Y. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0185 · Cited by 370 · see citing works

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia

Groenestege, W. M. T., Thébault, S. C., van der Wijst, J., van den Berg, D. J., Janssen, R., Tejpar, S., van den Heuvel, L. P., Cutsem, E. V., Hoenderop, J. G. J., Knoers, N. V. A. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31680 · Cited by 355 · see citing works

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors

Paria, B. C., Ma, W., Tan, J., Raja, S., Das, S. K., Dey, S. K., & Hogan, B. L. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1047 · Cited by 352 · see citing works

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0537588100 · Cited by 341 · see citing works

Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation

Hsieh, M., Lee, D., Panigone, S., Horner, K., Chen, R., Theologis, A. A., Lee, D. C., Threadgill, D. W., & Conti, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01919-06 · Cited by 329 · see citing works

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

Waterman, H., & Yarden, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02117-2 · Cited by 315 · see citing works

EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation?

Engel, J. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81417-6 · Cited by 305 · see citing works

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

Tokumaru, S., Higashiyama, S., Endo, T., Nakagawa, T., Miyagawa, J., Yamamori, K., Hanakawa, Y., Ohmoto, H., Yoshino, K., Shirakata, Y., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.209 · Cited by 305 · see citing works

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

Shirakata, Y., Kimura, R., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.02346 · Cited by 301 · see citing works

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

Chen, B., Bronson, R. T., Klaman, L. D., Hampton, T., Wang, J., Green, P. J., Magnuson, T., Douglas, P. S., Morgan, J. P., & Neel, B. G. (2000) · Nature Genetics · doi:10.1038/73528 · Cited by 300 · see citing works

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor

Swindle, C. S., Tran, K. T., Johnson, T. D., Banerjee, P., Mayes, A. M., Griffith, L., & Wells, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103103 · Cited by 286 · see citing works

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

Dong, J., Opresko, L. K., Dempsey, P. J., Lauffenburger, D. A., Coffey, R. J., & Wiley, H. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6235 · Cited by 263 · see citing works

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation

Anklesaria, P., Teixidó, J., Laiho, M., Pierce, J. H., Greenberger, J. S., & Massagué, J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3289 · Cited by 252 · see citing works

Targeting TACE-dependent EGFR ligand shedding in breast cancer

Kenny, P. A., & Bissell, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29518 · Cited by 248 · see citing works

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.

Cook, P. W., Piepkorn, M. W., Clegg, C. H., Plowman, G. D., DeMay, J. M., Brown, J. R., & Pittelkow, M. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119766 · Cited by 225 · see citing works

Possible role of transforming growth factor α in the pathogenesis of Ménétrier's disease: Supportive evidence from humans and transgenic mice

Dempsey, P. J., Goldenring, J. R., Soroka, C. J., Modlin, I. M., McClure, R. W., Lind, C. D., Ahlquist, D. A., Pittelkow, M. R., Lee, D. C., Sandgren, E. P., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91455-d · Cited by 220 · see citing works

Structure-Function relationships for the EGF/TGF-α family of mitogens

Groenen, L. C., Nice, E. C., & Burgess, A. W. (1994) · Growth Factors · doi:10.3109/08977199409010997 · Cited by 218 · see citing works

Membrane‐anchored growth factors, the epidermal growth factor family: Beyond receptor ligands

Higashiyama, S., Iwabuki, H., Morimoto, C., Hieda, M., Inoue, H., & Matsushita, N. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00676.x · Cited by 213 · see citing works

Amphiregulin: An early trigger of liver regeneration in mice

Berasain, C., García–Trevijano, E. R., Castillo, J., Erroba, E., Lee, D. C., Prìeto, J., & Avila, M. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.006 · Cited by 213 · see citing works

SnapShot: EGFR Signaling Pathway

Yarden, Y., & Shilo, B. (2007) · Cell · doi:10.1016/j.cell.2007.11.013 · Cited by 203 · see citing works

The many faces of epidermal growth factor repeats.

Cg, D. (1990) · PubMed · Cited by 199 · see citing works

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

Ibbotson, K. J., HARROD, J., Gowen, M., D'Souza, S. M., Smith, D. D., Winkler, M. E., Derynck, R., & Mundy, G. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.7.2228 · Cited by 179 · see citing works

Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily

Strachan, L., Murison, J. G., Prestidge, R. L., Sleeman, M. A., Watson, J. D., & Kumble, K. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006935200 · Cited by 171 · see citing works

Human transforming growth factor-alpha stimulates bone resorption in vitro.

Stern, P. H., Krieger, N. S., Nissenson, R. A., Williams, R. D., Winkler, M. E., Derynck, R., & Strewler, G. J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112202 · Cited by 168 · see citing works

Beyond Wavy Hairs

Schneider, M. R., Werner, S., Paus, R., & Wolf, E. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070942 · Cited by 161 · see citing works

Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblasts Revealed by Microarray and Bioinformatics

Qin, L., Qiu, P., Wang, L., Li, X., Swarthout, J. T., Soteropoulos, P., Tolias, P. P., & Partridge, N. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212226200 · Cited by 161 · see citing works

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

Nanba, D., Mammoto, A., Hashimoto, K., & Higashiyama, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303017 · Cited by 158 · see citing works

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas.

Am, D., Wang, X., King, L. E., Nanney, L., Ta, G., Sellheyer, K., Bundman, D. S., Longley, M., Rothnagel, J. A., & Da, G. (1993) · PubMed · Cited by 153 · see citing works

Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family

Hinkle, C. L., Sunnarborg, S. W., Loiselle, D. R., Parker, C. E., Stevenson, M. C., Russell, W. E., & Lee, D. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312141200 · Cited by 153 · see citing works

A Role for a PDZ Protein in the Early Secretory Pathway for the Targeting of proTGF-α to the Cell Surface

Fernández-Larrea, J., Merlos‐Suárez, A., Ureña, J. M., Baselga, J. M., & Arribas, J. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80470-0 · Cited by 151 · see citing works

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

Yamazaki, S., Iwamoto, R., Saeki, K., Asakura, M., Takashima, S., Yamazaki, A., Kimura, R., Mizushima, H., Moribe, H., Higashiyama, S., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200307035 · Cited by 145 · see citing works

Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach.

Takagi, H., Jhappan, C., Sharp, R., & Merlino, G. T. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115936 · Cited by 141 · see citing works

Maternal heparin-binding-EGF deficiency limits pregnancy success in mice

Xie, H., Wang, H., Tranguch, S. L., Iwamoto, R., Mekada, E., DeMayo, F. J., Lydon, J. P., Das, S. K., & Dey, S. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707909104 · Cited by 129 · see citing works

Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart

Sibilia, M. C., Wagner, B., Hoebertz, A., Elliott, C., Marino, S., Jochum, W., & Wagner, E. F. (2003) · Development · doi:10.1242/dev.00664 · Cited by 129 · see citing works

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach

Coffey, R. J., Washington, M. K., Corless, C. L., & Heinrich, M. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30491 · Cited by 126 · see citing works

Pulmonary Hypoplasia in Mice Lacking Tumor Necrosis Factor-α Converting Enzyme Indicates an Indispensable Role for Cell Surface Protein Shedding during Embryonic Lung Branching Morphogenesis

Zhao, J., Chen, H., Peschon, J. J., Shi, W., Zhang, Y., Frank, S. J., & Warburton, D. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0176 · Cited by 121 · see citing works

Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.

Takahashi, N., MacDonald, B. R., Hon, J. K., Winkler, M., Derynck, R., Mundy, G. R., & Roodman, G. D. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112677 · Cited by 120 · see citing works

Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network

Tzahar, E., Moyer, J. D., Waterman, H., Barbacci, E. G., Bao, J., Levkowitz, G., Shelly, M., Strano, S., Pinkas‐Kramarski, R., Pierce, J. H., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.5948 · Cited by 116 · see citing works

TACE is required for fetal murine cardiac development and modeling

Shi, W., Chen, H., Sun, J., Buckley, S., Zhao, J., Anderson, K. D., Williams, R. G., & Warburton, D. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00315-4 · Cited by 115 · see citing works

Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage

Lee, D., Pearsall, R. S., Das, S., Dey, S. K., Godfrey, V., & Threadgill, D. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8907-8916.2004 · Cited by 115 · see citing works

Selective Inhibition of Type I Collagen Synthesis in Osteoblastic Cells by Epidermal Growth Factor*

Hata, R., Hori, H., Nagai, Y., Tanaka, S., Kondo, M., Hiramatsu, M., Utsumi, N., & Kumegawa, M. (1984) · Endocrinology · doi:10.1210/endo-115-3-867 · Cited by 115 · see citing works

EGF-like Ligands Stimulate Osteoclastogenesis by Regulating Expression of Osteoclast Regulatory Factors by Osteoblasts

Zhu, J., Jia, X., Xiao, G., Kang, Y., Partridge, N. C., & Qin, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705064200 · Cited by 108 · see citing works

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

Merchant, N. B., Voskresensky, I. V., Rogers, C. M., LaFleur, B., Dempsey, P. J., Graves‐Deal, R., Revetta, F. L., Foutch, A. C., Rothenberg, M. L., Washington, M. K., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1216 · Cited by 107 · see citing works

Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation

Qin, L., Tamasi, J. A., Raggatt, L. J., Li, X., Feyen, J. H. M., Lee, D. C., DiCicco-Bloom, E. M., & Partridge, N. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409807200 · Cited by 104 · see citing works

Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity

Kochupurakkal, B. S., Harari, D., Segni, A. D., Maik-Rachline, G., Lyass, L., Gur, G., Kerber, G., Citri, A., Lavi, S., Eilam, R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413919200 · Cited by 103 · see citing works

Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasis

Normanno, N., Luca, A. D., Aldinucci, D., Maiello, M. R., Mancino, M., D’Antonio, A., Filippi, R. D., & Pinto, A. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00956 · Cited by 98 · see citing works

Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early‐onset, psoriasis‐like skin pathology: Expression of amphiregulin in the basal epidermis is also associated with synovitis

Cook, P. W., Brown, J. R., Cornell, K., & Pittelkow, M. R. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.00183.x · Cited by 96 · see citing works

Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage

Shirasawa, S., Sugiyama, S., Baba, I., Inokuchi, J., Sekine, S., Ogino, K., Kawamura, Y. I., Dohi, T., Fujimoto, M., & Sasazuki, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404217101 · Cited by 95 · see citing works

Effects of epidermal growth factor on osteoblastic cellsin vitro

Kumegawa, M., Hiramatsu, M., HATAKEYAMA, K., Yajima, T., Kodama, H., Osaki, T., & Kurisu, K. (1983) · Calcified Tissue International · doi:10.1007/bf02405091 · Cited by 89 · see citing works

Evolutionary Analysis of the ErbB Receptor and Ligand Families

Stein, R. A., & Staros, J. V. (2000) · Journal of Molecular Evolution · doi:10.1007/s002390010043 · Cited by 88 · see citing works

Overexpression of Epidermal Growth Factor Induced Hypospermatogenesis in Transgenic Mice

Wong, R. W.-C., Kwan, R. W.-P., Mak, P. H. S., Mak, K. K., Sham, M. H., & Chan, S. Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001965200 · Cited by 86 · see citing works

Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane

Hieda, M., Isokane, M., Koizumi, M., Higashi, C., Tachibana, T., Shudou, M., Taguchi, T., Hieda, Y., & Higashiyama, S. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710022 · Cited by 76 · see citing works

Expression of Epidermal Growth Factor in Transgenic Mice Causes Growth Retardation

Chan, S. Y., & Wong, R. W.-C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004189200 · Cited by 73 · see citing works

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